Death due to severe toxic epidermal necrolysis induced by tigecycline: a case report

Published on May. 07, 2024Total Views: 1114 times Total Downloads: 456 times Download Mobile

Author: LI Xiangjun ¹ XU Shanshan ²  TANG Jianjun ¹

Affiliation: 1. Department of Neurology, Shanghai Deji Hospital (Qingdao University, Shanghai Neuromedical Center), Shanghai 200333, China 2. Department of Pharmacy, Shanghai Deji Hospital (Qingdao University, Shanghai Neuromedical Center), Shanghai 200333, China

Keywords: Toxic epidermal necrolysis Tigecycline Drug adverse reaction

DOI: 10.12173/j.issn.1008-049X.202311246

Reference: LI Xiangjun, XU Shanshan, TANG Jianjun.Death due to severe toxic epidermal necrolysis induced by tigecycline: a case report[J].Zhongguo Yaoshi Zazhi,2024, 27(4):722-728.DOI: 10.12173/j.issn.1008-049X.202311246.[Article in Chinese]  Copied

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Abstract

In this paper, a case of toxic epidermal necrolysis (TEN) after application of tigecycline in an elderly patient was analyzed, and was analyzed and discussed combined with domestic and foreign literature. According to the criteria for assessing the association of adverse drug reactions, the TEN present in this patient is likely to be related to tigecycline. It is suggested that clinicians and pharmacists should be vigilant and pay attention to TEN that may be caused by tigecycline in clinical work.

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1.Bastuji-Garin S, Rzany B, Stern RS, et al. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme[J]. Arch Dermatol, 1993, 129(1): 92-96. https://pubmed.ncbi.nlm.nih.gov/8420497/.

2.White KD, Abe R, Ardern-Jones M, et al. SJS/TEN 2017: Building multidisciplinary networks to drive science and translation[J]. J Allergy Clin Immunol Pract, 2018, 6(1): 38-69. DOI: 10.1016/j.jaip.2017.11.023.

3.Chaby G, Maldini C, Haddad C, et al. Incidence of and mortality from epidermal necrolysis (Stevens-Johnson syndrome/toxic epidermal necrolysis) in France during 2003-2016: a four-source capture-recapture estimate[J]. Br J Dermatol, 2020, 182(3): 618-624.DOI: 10.1111/bjd.18424.

4.MarxerCA, Frey N, Bodmer M, et al. Survival after Stevens-Johnson Syndrome or toxic epidermal necrolysis: a United Kingdom-based cohort study[J]. J Invest Dermato, 2021, 141(5): 1349-1351. DOI: 10.1016/j.jid.2020.09.034.

5.Bastuji-Garin S, Fouchard N, Bertocchi M, et al. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis[J]. J Invest Dermatol, 2000, 115(2): 149-153. DOI: 10.1046/j.1523-1747.2000.00061.x.

6.Sassolas B, Haddad C, Mockenhaupt M, et al. ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson Syndrome and toxic epidermal necrolysis: comparison with case-control analysis[J]. Clin Pharmacol Ther, 2010, 88(1): 60-68. DOI: 10.1038/clpt.2009.252.

7.Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions[J]. Clin Pharmacol Ther, 1981, 30(2): 239-245. DOI: 10.1038/clpt.1981.154.

8.Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs[J]. N Engl J Med, 1994, 331(19): 1272-1285. DOI: 10.1056/NEJM199411103311906.

9.朱金莲. 口服氟康唑片导致重症过敏性药疹一例报告 [J].青海医药杂志, 2015, 45(7): 26. [Zhu, JL. A case report of severe allergic drug eruption caused by oral administration of fluconazole tablets[J]. Qinghai Medical Journal, 2015, 45(7): 26.] DOI: CNKI:SUN:QHYZ. 0.2015-07-011.

10.魏光华. 氟康唑致HIV感染者重症多形性红斑型药疹[J]. 药物不良反应杂志, 2006, 8(6): 458-459. [Wei, GH. Severe polymorphic erythema-type drug eruption caused by fluconazole in HIV-infected patients[J]. Journal of Adverse Drug Reactions, 2006, 8(6): 458-459.] DOI: 10.3969/j.issn.1008-5734.2006.06.034.

11.王凌. 哌拉西林钠他唑巴坦钠致中毒性表皮坏死松解症[J]. 药物不良反应杂志, 2016, 18(6): 451-452. [Wang L. Toxic epidermal necrolysis caused by piperacillin-tazobactam[J]. Journal of Adverse Drug Reactions, 2016, 18(6): 451-452.] DOI: 10.3760/cma.j.issn.1008-5734. 2016.06.011.

12.王维波, 宁金堂, 田明忠, 等. 浅析奈玛特韦片/利托那韦片组合包装治疗新型冠状病毒感染的研究进展[J]. 中国合理用药探索, 2023, 20(9): 8-12. [Wang WB, Ning JT Tian, MZ, et al. A brief analysis of the research progress in the treatment of novel coronavirus infection with nematode tablets/ritonavir tablets combination packaging[J]. Chinese Journal of Rational Drug Use Exploration, 2023, 20(9): 8-12.] DOI: 10.3969/j.issn.2096-3327.2023.09.002.

13.Yang J, Wu F, Luo D, et al. Toxic epidermal necrolysis syndrome induced by tigecycline: a case report[J]. J Int Med Res, 2020, 48(5): 300060520922416. DOI: 10.1177/0300060520922416.

14.方秀容. 硫酸阿米卡星致皮疹3例[J].中国现代应用药学, 2000, 17(S1): 147. [Fang, XR. Three cases of skin rash induced by amikacin sulfate[J]. Chinese Journal of Modern Applied Pharmacy, 2000, 17(S1): 147.] DOI: 10.13748/j.cnki.issn1007-7693.2000.s1.235.

15.银哲. 阿米卡星致过敏性皮炎一例[J]. 医药导报, 1999, 18(4): 276. [Yin, Z. A case of allergic dermatitis caused by amikacin[J]. Herald of Medicine, 1999, 18(4): 276.] DOI: 10.3870/j.issn.1004-0781.1999.04.069.

16.Heng YK, Lee HY, Roujeau JC. Epidermal necrolysis: 60 years of errors and advances[J]. Br J Dermatol, 2015, 173(5): 1250-1254. DOI: 10.1111/bjd.13989.

17.Su SC, Mockenhaupt M, Wolkenstein P, et al. Interleukin-15 is associated with severity and mortality in Stevens-Johnson syndrome/toxic epidermal necrolysis[J]. J Invest Dermatol, 2017, 137(5): 1065-1073. DOI: 10.1016/j.jid.2016.11.034.

18.Jean-Claude G. The culprit drugs in 87 cases of toxic epidermal necrolysis (Lyell's syndrome)[J]. Arch Dermatol, 1987, 123(9): 1166-1170. DOI: 10.1001/archderm.1987.01660330077013.

19.Chung WH, Hung SI, Yang JY, et al. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis[J]. Nat Med, 2008, 14(12): 1343-1350. DOI: 10.1038/nm.1884.

20.Viard I, Wehrli P, Bullani R, et al. Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin[J]. Science, 1998, 282. DOI: 10.1126/science.282.5388.490.

21.Roujeau JC. Stevens-Johnson syndrome and toxic epidermal necrolysis are severity variants of the same disease which differs from erythema multiforme[J]. J Dermatol, 1997, 24(11): 726-729. DOI: 10.1111/j.1346-8138.1997.tb02524.x.

22.马琳. 金葡菌烫伤样皮肤综合征[J]. 中国实用儿科杂志, 2001, 16(11): 648-649. [Ma L. Staphylococcus aureus scalded skin syndrome[J]. Chinese Journal of Applied Pediatrics, 2001, 16(11): 648-649.] DOI: 10.3969/j.issn.1005-2224.2001.11.007.

23.Roujeau JC, Bastuji-Garin S. Systematic review of treatments for Stevens-Johnson syndrome and toxic epidermal necrolysis using the SCORTEN score as a tool for evaluating mortality[J]. Ther Adv Drug Saf, 2011, 2(3): 87-94. DOI: 10.1177/2042098611404094.

24.Letko E, Papaliodis DN, Papaliodis GN, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature[J]. Ann Allergy Asthma Immunol, 2005, 94(4): 419-436. DOI: 10.1016/S1081-1206(10)61112-X.

25.卢文超, 韦元元, 李光耀, 等. 替加环素致中毒性表皮坏死松解症的病例分析[J]. 中国临床药理学杂志, 2019, 35(11): 1183-1185. [Lu, WC, Wei YY, Li, GY, et al. Case analysis of toxic epidermal necrolysis caused by tigecycline[J]. Chinese Journal of Clinical Pharmacology, 2019, 35(11): 1183-1185.] DOI: 10.13699/j.cnki.1001-6821.2019.11.025.

26.Schneider JA, Cohen PR. Stevens-Johnson syndrome and toxic epidermal necrolysis: a concise review with a comprehensive summary of therapeutic interventions emphasizing supportive measures[J]. Adv Ther, 2017, 34(6): 1235-1244. DOI: 10.1007/s12325-017-0530-y.

27.徐珊珊, 谢雪萍, 田亮, 等. 美罗培南致Stevens-Johnson综合征1例[J]. 中国药师, 2022, 25(2): 306-308. [Xu SS, Xie XP, Tian L, et al. A case of Stevens-Johnson syndrome caused by meropenem[J]. Chinese Pharmacists, 2022, 25(2): 306-308.] DOI: 10.19962/j.cnki.issn1008-049X.2022.02.019.