Objective  To explore the medication rules for the clinical treatment of chronic atrophic gastritis (CAG) with dysplasia (Dys) using data mining techniques, and to provide references for the prescription and medication in the clinical treatment of CAG with Dys by traditional Chinese medicine.

Methods  Based on the keywords such as "traditional Chinese medicine" and "chronic atrophic gastritis with dysplasia", literature were searched in three databases, CNKI, Wanfang Data and VIP. The screened literature was collated, a database was established, and the frequencies of drugs and their properties, tastes and meridian tropism were summarized. Softwares such as SPSS Statistics 26.0, SPSS Modeler 18.0 and Cytoscape 3.9.1 were used to conduct cluster analysis, association rule analysis, and to draw the complex network diagrams of the drugs.

Results  Eventually, 153 pieces of literature were screened out, involving 228 types of drugs with a total frequency of 2 212 times. There were 16 types of high-frequency drugs with a usage frequency of ≥ 25 times, mainly including Glycyrrhizae radix et rhizoma, Atractylodis macrocephalae rhizoma, Codonopsis radix and Paeoniae radix alba. The drugs were mainly heat-clearing drugs, qi-regulating drugs, and blood-activating and stasis-removing drugs. The four natures were mainly bitter and sweet, the five tastes were mainly warm and cold, and the meridian tropism were mainly spleen, stomach, lung and liver. A total of 29 groups of commonly used drug combinations were obtained through association rule analysis, and 5 new prescriptions were obtained through cluster analysis.

Conclusion  This study indicates that the traditional Chinese medicine pathogenesis of CAG with Dys is based on the weakness of the spleen and stomach, with qi stagnation, dampness-heat, and blood stasis as the manifestations. The treatment is based on the fundamental therapeutic method of tonifying qi and strengthening the spleen, while attaching importance to the combined use of drugs for clearing heat and drying dampness, soothing the liver and regulating qi, promoting blood circulation and detoxification.

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