Panaxnotoginseng saponins is widely used in the treatment of clinical cardiac cerebrovascular disease due to its excellent anticoagulant and hemodynamics effects. This review sorted out and analyzed the biosynthetic pathway of Panaxnotoginseng saponins, summarized the role of key enzymes involved expression regulation such as farnesyl pyrophaophate synthase, squalene synthase, squalene epoxidase, dammarenediol-II synthase, oxidosqualene cyclase, cytochrome P450 monooxygenases, and glycosyltransferase. Meanwhile, the research progress in the construction of heterologous synthetic pathways and the regulation of biosynthesiswerealsogeneralized, toprovide reference for the optimization of the biosynthetic method.

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