Zingiberis rhizoma (dried ginger), a traditional Chinese medicine with both medicinal and edible values, exerts the traditional effects of warming the middle energizer to dispel cold, recovering yang to unblock the meridians, and warming the lung to resolve fluid retention. Modern research has found that dried ginger contains a variety of active components, including volatile oils, gingerol, diphenylheptane, flavonoids, amino acids, glycosides and inorganic elements, etc. Its pharmacological effects mainly include anti-inflammatory and analgesic effects, antiemetic, anti-tumor, antioxidant, anti-infection, immune regulation, improvement of cardiovascular and cerebrovascular systems, hy-poglycemic, and inhibition of platelet aggregation, etc. Modern pharmacological studies have found that dried ginger has potential anti-gastric cancer effects of dried ginger, but the understanding of its anti-cancer activity and related mechanisms of action is quite limited. Therefore, this paper reviews the research reports on the chemical constituents and pharmacological effects of dried ginger at home and abroad in recent years, in order to provide reference for the subsequent development of dried ginger.

1. 中国药典2025年版. 一部[S]. 2025: 16.

2. 佚名, 著. 支晓娟, 整理. 神农本草经[M]. 广州: 广东科学技术出版社, 2022: 118.

3. 梁·陶弘景, 撰. 名医别录[M]. 海口: 海南出版社, 2025: 中品卷第二.

4. 明·刘文泰. 本草品汇精要[M]. 兰州: 敦煌文艺出版社, 2018: 卷之三十九·菜部中品.

5. 明·李中梓, 撰. 雷公炮制药性解[M]. 北京: 人民军医出版社. 2013: 180.

6. 清·周岩. 本草思辨录[M]. 太原: 山西科学技术出版社, 2015: 178.

7. 汪杰, 黄山, 张正, 等. 经典名方中干姜的本草考证[J]. 中成药, 2025, 47(2): 544-548. [Wang J, Huang S, Zhang Z, et al. Herbal textual research on dried ginger in classical famous formulae[J]. Chinese Traditional Patent Medicine, 2025, 47(2): 544-548.] DOI: 10.3969/j.issn.1001-1528.2025.02.028.

8. 谢晋, 王德群. 中药干姜产地和品种考证[C]. 合肥: 第十八届全国药学史暨本草学术研讨会学术论文集, 2015: 110-112.

9. 卞华, 主编. 伤寒杂病论[M]. 北京: 中医古籍出版社, 2012: 574.

10. 金岚. 张仲景运用干姜的规律研究[D]. 北京: 北京中医药大学, 2018.

11. 苗小玲, 王付. 王付教授运用半夏泻心汤合方札记[J]. 辽宁中医药大学学报, 2011, 13(10): 195-196. [Miao XL, Wang F. Professor Wang Fu's notes on the application of Banxia Xiexin Tang combination[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2011, 13(10): 195-196.] DOI: 10.13194/j.jlunivtcm.2011.10.197.miaoxl.038.

12. 王建斌. 半夏泻心汤加味治疗胃癌前病变27例[J]. 西部中医药, 2011, 24(12): 45-48. [Wang JB. Observation on efficacy of modified BanXia XieXinTang in treating 27 cases of gastric precancerosis[J]. Western Journal of Traditional Chinese Medicine, 2011, 24(12): 45-48.] DOI: 10.3969/j.issn.1004-6852.2011.12.018.

13. 朱燕娴, 杜少辉, 黄玮，等. 杜少辉应用经方论治胃癌经验[J]. 中医药导报, 2022, 28(11): 114-116. [Zhu YX, Du SH, Huang W, et al. Professor Du Shaohui's experience in treating gastric cancer with classical formulas[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2022, 28(11): 114-116.] DOI: 10.13862/j.cn43-1446/r.2022.11.025.

14. 张少聪. 《伤寒杂病论》辨治肿瘤病思路探讨与典型案例分析[D]. 广州: 广州中医药大学, 2011.

15. 王哲. 干姜化学成分的研究[D]. 长春: 吉林大学, 2013.

16. 罗祺玮, 钟萍, 孟钢, 等. 生姜与干姜挥发油化学成分及药理作用研究进展[J]. 生物化工, 2024, 10(3): 184-188. [Luo QW, Zhong P, Meng G, et al. Advance on chemical constituents and pharmacological effects of fresh gingers and dried gingers essential oil[J]. Biological Chemical Engineering, 2024, 10(3): 184-188.] DOI: 10.3969/j.issn.2096-0387.2024.03.039.

17. 朱萱萱, 苗兰, 孟硕, 等. 基于GC-MS和网络药理学预测生姜炮制前后挥发性成分中的质量标志物[J]. 中国现代中药, 2023, 25(12): 2479-2491. [Zhu XX, Miao L, Meng S, et al. Q-Marker prediction of volatile components of crude and processed ginger based on GC-MS and network pharmacology[J]. Modern Chinese Medicine, 2023, 25(12): 2479-2491.] DOI: 10.13313/j.issn.1673-4890.20230717002.

18. Wang Y, Qing M, Li H, et al. The volatile oil of dried ginger promotes intestinal epithelial renewal through T-UCR uc.481[J]. J Agric Food Chem, 2025, 73(34): 21389-21403. DOI: 10.1021/acs.jafc.5c02193.

19. Hao Y, Lin X, Liu W, et al. Development of nanofiber facial mask inspired by the multi-function of dried ginger (Zingiberis Rhizoma) essential oil [J]. Sci Rep, 2025, 15(1): 402. DOI: 10.1038/s41598-024-84571-1.

20. 顾琦, 魏旭超, 刘露，等. 基于网络药理学探讨辛热中药挥发油外用的药效物质基础及潜在分子机制[J]. 中草药, 2021, 52(5): 1383-1392. [Gu Q, Wei XC, Liu L, et al. Pharmacodynamic material basis and potential molecular mechanism for external use of essential oils from "hot" pungent Chinese materia medica based on network pharmacology[J]. Chinese Traditional and Herbal Drugs, 2021, 52(5): 1383-1392.] DOI: 10.7501/j.issn.0253-2670.2021.05.019.

21. 陈颖, 刘冬, 周静，等. 干姜挥发油对急性心肌缺血缺氧模型大鼠血清中肿瘤坏死因子水平的影响[J]. 名医, 2021, (8): 36-37. [Chen Y, Liu D, Zhou J, et al. Effects of volatile oil of dried ginger on serum levels of tumor necrosis factor in rats with acute myocardial ischemia and hypoxia[J]. Renowned Doctor, 2021, (8): 36-37.] DOI: 10.20255/j.cnki.issn1674-9561.2021.08.005.

22. 李申澳, 余卫东, 许寅，等. 生姜与干姜的化学成分、药理作用、处方应用研究进展及其质量标志物预测分析[J]. 中国中药杂志, 2025, 50(20): 5641-5657. [Li SA, Yu WD, Xu Y, et al. Research progress on chemical constituents, pharmacological effects, and prescription application of Zingiberis Rhizoma Recens and Zingiberis Rhizoma and prediction of their quality markers[J]. China Journal of Chinese Materia Medica, 2025, 50(20): 5641-5657.] DOI: 10.19540/j.cnki.cjcmm.20250603.203.

23. 张梦欣, 高铭淑, 黄传奇，等. 姜的化学成分、药理作用及增效减毒配伍机制研究进展[J]. 中华中医药学刊, 2025-04-21. [Zhang MX, Gao MS, Huang CQ, et al.  Research progress on chemical constituents, pharmacological effects and effect-enhancing and toxic-reducing compatibility mechanism of ginger[J]. Chinese Archives of Traditional Chinese Medicine, 2025-04-21.] https://kns.cnki.net/kcms2/article/abstract?v=iwDheDcO5w56EIVgRDfuJNu-NF3L8XO9_jbWr2lsF3KRe1s8dI37mf1OAGaHLX4p4gnQ4_zoNHFnnxNXSwO8cA6Dk04yi0IRM70Pz0ADfzuy_eOoiUBxrJP01O4sAmfZqy0Q5B0vzUjl2TW0NccR9I4sMqI5HKWEzcX4NMOGibBzOlgyJoOhdLqdhTXO61Zz3gcIqxBkGdI&uniplatform=NZKPT&captchaId=6e0ff48c-b785-449e-92f2-037be6dd9cc2.

24. 余代鑫, 尹梦廷, 郭盛，等. 基于GC-MS和FT-NIR结合化学计量学的干姜产地鉴别及挥发性成分含量快速预测[J]. 中国现代中药, 2025, 27(5): 831-841. [Yu DX, Yin MT, Guo S, et al. Identification of geographical origin and rapid prediction of volatile component of Zingiberis Rhizoma via GC-MS and FT-NIR with chemometrics[J]. Modern Chinese Medicine, 2025, 27(5): 831-841.] DOI: 10.13313/j.issn.1673-4890.20240925002.

25. 朱明明, 柳丹, 路可欣, 等. 姜辣素药理作用研究进展[J]. 湖北医药学院学报, 2018, 37(4): 390-394. [Zhu MM, Liu D, Lu  KX, et al. Research progress on the pharmacological effects of gingerols[J]. Journal of Hubei University of Medicine, 2018, 37(4): 390-394.] DOI: 10.13819/j.issn.1006-9674.2018.04.025.

26. 田舒铭. 生姜种质资源姜辣素含量评价及其关键合成基因功能鉴定[D]. 重庆: 重庆三峡学院, 2023.

27. Lgaz H, Messali M, Lee HS. Mechanistic evaluation of radical scavenging pathways in ginger phenolics: a DFT study of 6-gingerol, 6-shogaol, and 6-paradol[J]. Int J Mol Sci, 2025, 26(22): 11217. DOI: 10.3390/ijms262211217.

28. 吴萍, 蒯梦妮, 李乐，等. 干姜化学成分和药理作用研究进展[J]. 亚太传统医药, 2024, 20(11): 242-246. [Wu P, Kuai  MN, Li L, et al. Research progresson chemical constituentsand pharmacological effectsof dried ginger[J]. Asia-Pacific Traditional Medicine, 2024, 20(11): 242-246.] DOI: 10.11954/ytctyy.202411048.

29. 何建桥, 张淼, 杨志军，等. 干姜的性效、炮制历史沿革及成分活性研究进展[J]. 中药材, 2024, 47(2): 497-505. [He  JQ, Zhang M, Yang ZJ, et al. Research progress on the efficacy, historical evolution of processing and component activity of dried ginger[J]. Journal of Chinese Medicinal Materials, 2024, 47(2): 497-505.] DOI: 10.13863/j.issn1001-4454.2024.02.041.

30. 卢传坚. 姜的化学成分分析研究概述[J]. 中药新药与临床药理, 2003, 14(3): 215-217. [Lu CJ. Overview of chemical composition analysis of ginger[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2003, 14(3): 215-217.] DOI: 10.3321/j.issn:1003-9783.2003.03.028.

31. Cui WH, Wang YZ, Li ZZ, et al. Four new diarylheptanoids from Rhizoma Zingiberis[J]. J Asian Nat Prod Res, 2019, 21(1): 1-8. DOI: 10.1080/10286020.2018.1545761.

32. 徐桐, 丛竹凤, 贺梦媛, 等. 干姜的研究进展及质量标志物分析[J]. 山东中医杂志, 2022, 41(5): 569-575. [Xu T, Cong ZF, He MY, et al. Research progress and quality marker analysis of Ganjiang (Zingiberis Rhizoma)[J]. Shandong Journal of Traditional Chinese Medicine, 2022, 41(5): 569-575.] DOI: 10.16295/j.cnki.0257-358x.2022.05.021.

33. Wei QY, Ma JP, Cai YJ, et al. Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger[J]. J Ethnopharmacol, 2005, 102(2): 177-184. DOI: 10.1016/j.jep.2005.05.043.

34. 肖盛元, 刘红霞, 林文翰, 等. 干姜中的二芳基庚烷类化合物及其在四逆汤煎煮过程中的立体选择性反应[J]. 分析化学, 2007, 35(9): 1295-1300. [Xiao SY, Liu HX, Lin WH, et al. Diarylheptanoids in Rhizoma Zingiberis and their stereoslective reactions during the process of decocting[J]. Chinese Journal of Analytical Chemistry, 2007, 35(9): 1295-1300.] DOI: 10.3321/j.issn:0253-3820.2007.09.011.

35. 卢敏, 黄艳, 陈艳艳，等. 姜中姜辣素和黄酮的提取及抗氧化性研究[J]. 广州化工, 2022, 50(20): 51-54. [Lu M, Huang Y, Chen YY, et al. Study on extraction and antioxidant activity of gingerol and flavonoids from ginger[J]. Guangzhou Chemical Industry, 2022, 50(20): 51-54.] DOI: 10.3969/j.issn.1001-9677.2022.20.015.

36. 李计萍, 王跃生, 马华, 等. 干姜与生姜主要化学成分的比较研究[J]. 中国中药杂志, 2001, 26(11): 748-751. [Li  JP, Wang YS, Ma  H, et al. A comparative study on the primary chemical constituents of Zingiberis Rhizoma (dried ginger) and Zingiberis Rhizoma Recens (fresh ginger)[J]. China Journal of Chinese Materia Medica, 2001, 26(11): 748-751.] DOI: 10.3321/j.issn:1001-5302.2001.11.010.

37. 张美慧, 李瑞海. 不同产地干姜中氨基酸成分对比研究  [J]. 中国民族民间医药, 2019, 28(20): 32-35. [Zhang MH, Li  RH. Comparison of amino acids in dried ginger from different habitats[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2019, 28(20): 32-35.] DOI: 10.3969/j.issn.1007-8517.2019.20.zgmzmjyyzz201920009.

38. 闫利利. 基于液质联用技术的半夏泻心汤药效物质定性研究 [D]. 北京: 北京协和医学院, 2013. https://cdmd.cnki.com.cn/Article/CDMD-10023-1013311387.htm.

39. 亓雪, 张颖颖. 干姜的化学、药理研究进展[J]. 山东化工, 2018, 47(14): 41-42. [Qi X, Zhang YY. Progress in chemical and pharmacological research of ginger[J]. Shandong Chemical Industry, 2018, 47(14): 41-42.] DOI: 10.19319/j.cnki.issn.1008-021x.2018.14.014.

40. 邹冬倩, 严辉, 李鹏辉, 等. 基于ICP-AES的不同产地干姜无机元素分析与评价[J]. 食品工业科技, 2020, 41(23): 240-246. [Zou DQ, Yan H, Li PH, et al. Analysis and evaluation of inorganic elements in Zingiberis Rhizoma from different rigions based on ICP-AES[J]. Science and Technology of Food Industry, 2020, 41(23): 240-246.] DOI: 10.13386/j.issn1002-0306.2020060124.

41. 于华芸, 吴智春, 季旭明, 等. 干姜温中功效的分子机制[J]. 中华中医药杂志, 2012, 27(1): 181-183. [Yu HY, Wu ZC, Ji XM, et al. Study on the molecule mechanism of warming interior of Zingiberis[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2012, 27(1): 181-183.] DOI: CNKI:SUN:BXYY.0.2012-01-055.

42. Young HY, Luo YL, Cheng HY, et al. Analgesic and anti-inflammatory activities of 6-gingerol[J]. J Ethnopharmacol, 2005, 96(1-2): 207-210. DOI: 10.1016/j.jep.2004.09.009.

43. 王梦, 钱红美, 苏简单. 干姜乙醇提取物解热镇痛及体外抑菌作用研究[J]. 中药新药与临床药理, 2003, 14(5): 299-301. [Wang M, Qian HM, Su JD. Antipyretic and analgesic effects of Rhizoma Zingiberis alcoholic extract and its in-vitro antibacterial actions[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2003, 14(5): 299-301.] DOI: 10.3321/j.issn:1003-9783.2003.05.003.

44. 王欢欢, 郭琴, 彭高强, 等. 基于古籍的生姜和干姜来源、功效及用法研究[J]. 长春中医药大学学报, 2022, 38(1): 17-21. [Wang HH, Guo Q, Peng GQ, et al. Investigation on the origin, efficacy and application of fresh gingers and dried gingers based on ancient books[J]. Journal of Changchun University of Chinese Medicine, 2022, 38(1): 17-21.] DOI: 10.13463/j.cnki.cczyy.2022.01.005.

45. 蒋苏贞, 朱春丽. 干姜醇提取物对胃排空的影响[J]. 中国当代医药, 2010, 17(14): 17-18. [Jiang SZ, Zhu CL. Effect of ethanolic dried ginger extract on gastric emptying[J]. China Modern Medicine, 2010, 17(14): 17-18.] DOI: 10.3969/j.issn.1674-4721.2010.14.009.

46. Liang W, Feng L, Han S, et al. 6-gingerol alleviates chemotherapy-induced nausea and vomiting by inhibiting ferroptosis via the regulation of iron homeostasis[J]. Cancer Chemother Pharmacol, 2025, 95(1): 119. DOI: 10.1007/s00280-025-04850-0.

47. 吴文春, 董敏, 陈莹昊, 等. 姜辣素穴位敷贴对全麻患者术后恶心呕吐的作用及机制[J]. 贵州医科大学学报, 2023, 48(11): 1406-1410, 1416. [Wu WC, Dong M, Chen YH, et al. Effect of gingerol acupoint application on postoperative nausea and vomiting in patients with general anesthesia and its mechanism[J]. Journal of Guizhou Medical University, 2023, 48(11): 1406-1410, 1416.] DOI: 10.19367/j.cnki.2096-8388.2023.11.020.

48. Tian M, Wu X, Hong Y, et al. Comparison of chemical composition and bioactivities of essential oils from fresh and dry rhizomes of Zingiber zerumbet (L.) Smith[J]. Biomed Res Int, 2020, 2020: 9641284. DOI: 10.1155/2020/9641284.

49. Zhang W, Liu Z, Luo L, et al. GC-MS- and LC-TOF-MS/MS-based ginger volatile oil serum analysis and the potential mechanism of the anticancer effect of serum component citral on MCF-7 breast cancer cells[J]. J Pharm Pharmacol, 2025, 77(4): 532-549. DOI: 10.1093/jpp/rgae116.

50. 吴其翔, 徐涛. 6-姜酚在癌症治疗中的作用[J]. 生命的化学, 2025, 45(8): 1344-1351. [Wu QX, Xu T. Roles of 6-gingerol in cancer treatment[J]. Chemistry of Life, 2025, 45(8): 1344-1351.]DOI: 10.13488/j.smhx.20250080.

51. Zhang XG, Song JN. 6-gingerol enhances the anti-tumor activity of temozolomide by inhibiting EGR1/GDF15 signaling in glioblastoma[J]. Sci Rep, 2025, 15(1): 42162. DOI: 10.1038/s41598-025-26109-7.

52. 贾晓娟. 6-姜烯酚对人卵巢癌SKOV-3和A2780细胞生长和促炎因子表达的抑制作用[D]. 成都: 成都中医药大学, 2015. https://cdmd.cnki.com.cn/Article/CDMD-10633-1016042761.htm.

53. 赵行宇, 张漠, 朱志华，等. 6-姜烯酚对胃癌BGC-823细胞侵袭及迁移的影响及相关作用机制研究[J]. 上海中医药杂志, 2020, 54(10): 82-86. [Zhao XY, Zhang M, Zhu ZH, et al. Study of 6-gingerol on invasion and migration of human gastric cancer BGC-823 cells[J]. Shanghai Journal of Traditional Chinese Medicine, 2020, 54(10): 82-86.] DOI: 10.16305/j.1007-1334.2020.2002064.

54. 张怡. 干姜中6-姜烯酚的抗肝癌作用机制和6-姜烯酚纳米乳的制备及其药效评价研究[D]. 武汉: 湖北中医药大学, 2022. https://cdmd.cnki.com.cn/Article/CDMD-10507-1022043722.htm.

55. 余娅娅, 朱燕娟, 肖真真, 等. 知母、干姜对PI3K/AKT通路异常激活介导的非小细胞肺癌吉非替尼耐药的影响及机制研究[J]. 中药新药与临床药理, 2023, 34(11): 1525-1533. [Yu YY, Zhu YJ, Xiao ZZ, et al. Effect and mechanism study of Anemarrhenae Rhizoma and Zingiberis Rhizoma recens on gefitinib resistance in non-small cell lung cancer mediated by abnormal activation of PI3K/AKT pathway[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2023, 34(11): 1525-1533.] DOI: 10.19378/j.issn.1003-9783.2023.11.005.

56. 武雨朦, 曙丽盼·木拉提, 张苗苗, 等. 基于网络药理学探究6-姜烯酚对黑色素瘤的药效研究 [J]. 食品与药品, 2025, 27(5): 398-403. [Wu YM, MuLaTi SLP, Zhang MM, et al. Investigation of therapeutic efficacy of 6-shogaol against melanoma based on network pharmacology[J]. Food and Drug, 2025, 27(5): 398-403.] DOI: 10.3969/j.issn.1672-979X.2025.05.003.

57. 刘怡妙, 凌悦, 徐旭, 等. 生姜的研究进展及其质量标志物的预测分析[J]. 中草药, 2022, 53(9): 2912-2928. [Liu  YM, Ling  Y, Xu X, et al. Research progress on ginger and predictive analysis on its Q-Marker[J]. Chinese Traditional and Herbal Drugs, 2022, 53(9): 2912-2928.] DOI: 10.7501/j.issn.0253-2670.2022.09.035.

58. Mustafa I, Chin NL. Antioxidant properties of dried ginger (Zingiber officinale Roscoe) var. Bentong[J]. Foods, 2023, 12(1):178. DOI: 10.3390/foods12010178.

59. 王霄凯, 张凡, 李姣, 等. 干姜和黑豆蔻体外抗氧化及降血糖功能的研究[C]. 宁波: 达能营养中心第二十二届学术会议——饮水、水合状态与健康会议论文集, 2019: 76-85.

60. 刘宏, 熊燊源. 干姜提取物对运输应激花鲈血液生化指标、抗氧化能力和肌肉能量代谢的影响[J]. 中国饲料, 2025, (20): 49-52. [Liu H, Xiong SY. Effects of dried ginger extract on blood biochemical indicators, antioxidant capacity and energy metabolism in muscle of lateolabrax japonicus suffered from transport stress[J]. China Feed, 2025, (20): 49-52.] DOI: 10.15906/j.cnki.cn11-2975/s.20252013.

61. 赖文静, 张星, 黄友, 等. 生物酶解法提取干姜精油的工艺及其生物活性评价[J]. 成都大学学报（自然科学版）, 2023, 42(3): 239-247. [Lai WJ, Zhang X, Huang Y, et al. Enzymatic extraction of essential oil from Zingiberis Rhizoma and its biological activity evaluation[J]. Journal of Chengdu University (Natural Science Edition), 2023, 42(3): 239-247.] DOI: 10.3969/j.issn.1004-5422.2023.03.004.

62. 于泽, 韩肖洋, 陈静, 等. 生姜中姜辣素的提取与功能研究进展[J]. 食品研究与开发, 2023, 44(3): 219-224. [Yu Z, Han  XY, Chen J, et al. Research progress on extraction and function of gingerol from ginger[J]. Food Research and Development, 2023, 44(3): 219-224.] DOI: 10.12161/j.issn.1005-6521.2023.03.032.

63. Oliveira HBM, Selis ND, Brito TLS, et al. Citral modulates human monocyte responses to infection[J]. Sci Rep-Uk, 2021, 11(1): 22029. DOI: 10.1038/s41598-021-01536-4.

64. Tanikawa T, Hayashi T, Kiba Y, et al. Inhibitory effect of 6-shogaol against 3CLpro activity and SARS-CoV-2 infection[J]. BMC Complement Med Ther, 2025, 25(1): 385. DOI: 10.1186/s12906-025-05094-4.

65. Zafrilla P, Ballester P, Victoria-Montesinos D, et al. Dietary bioactive compounds and their role in allergy prevention: a comprehensive review[J]. Nutrients, 2025, 17(22): 3506. DOI: 10.3390/nu17223506.

66. 张莉华, 陈少军. 生姜对新型冠状病毒肺炎的防治作用探讨 [J]. 中国食品学报, 2020, 20(12): 302-310. [Zhang  LH, Chen  SJ. Studies on the control effect of ginger on novel coronavirus pneumonia[J]. Journal of Chinese Institute of Food Science and Technology, 2020, 20(12): 302-310.] DOI: 10.16429/j.1009-7848.2020.12.036.

67. Han X, Qi J, Yang Y, et al. Protective mechanisms of 10-gingerol against myocardial ischemia may involve activation of JAK2/STAT3 pathway and regulation of Ca2+ homeostasis[J]. Biomed Pharmacother, 2022, 151: 113082. DOI: 10.1016/j.biopha.2022.113082.

68. Ma SQ, Guo Z, Liu FY, et al. 6-gingerol protects against cardiac remodeling by inhibiting the p38 mitogen-activated protein kinase pathway[J]. Acta Pharmacol Sin, 2021, 42(10): 1575-1586. DOI: 10.1038/s41401-020-00587-z.

69. Khan G, Alam MF, Alshahrani S, et al. Trastuzumab-mediated cardiotoxicity and its preventive intervention by zingerone through antioxidant and inflammatory pathway in rats[J]. J Pers Med, 2023, 13(5): 750. DOI: 10.3390/jpm13050750.

70. Rao O, Hu J, Zhu N, et al. 6-shogaol alleviates post-cardiopulmonary resuscitation brain injury in rats by regulating the miRNA-26a-5p/DAPK1[J]. Neurochem Res, 2025, 51(1): 8. DOI: 10.1007/s11064-025-04610-9.

71. Su M, Cao G, Wang X, et al. Metabolomics study of dried ginger extract on serum and urine in blood stasis rats based on UPLC-Q-TOF/MS[J]. Food Sci Nutr, 2020, 8(12): 6401-6414. DOI: 10.1002/fsn3.1929.

72. Han Y, Li Y, Wang Y, et al. Comparison of fresh, dried and stir-frying gingers in decoction with blood stasis syndrome in rats based on a GC-TOF/MS metabolomics approach[J]. J Pharm Biomed Anal, 2016, 129: 339-349. DOI: 10.1016/j.jpba.2016.07.021.

73. 汪妮, 陈梦霞, 孟凡强, 等. 生姜多糖的提取及其对糖尿病小鼠肠道菌群的调节作用[J]. 食品工业科技, 2023, 44(4): 278-286. [Wang N, Chen MX, Meng FQ, et al. Extraction of polysaccharide from Zingiber officinale Roscoe and its regulatory effect on intestinal flora in diabetic mice[J]. Science and Technology of Food Industry, 2023, 44(4): 278-286.] DOI: 10.13386/j.issn1002-0306.2022060155.

74. Yi JK, Ryoo ZY, Ha JJ, et al. Beneficial effects of 6-shogaol on hyperglycemia, islet morphology and apoptosis in some tissues of streptozotocin-induced diabetic mice[J]. Diabetol Metab Syndr, 2019, 11: 15. DOI: 10.1186/s13098-019-0407-0.

75. Tzeng TF, Liu IM. 6-gingerol prevents adipogenesis and the accumulation of cytoplasmic lipid droplets in 3T3-L1 cells[J]. Phytomedicine, 2013, 20(6): 481-487. DOI: 10.1016/j.phymed.2012.12.006.

76. Zhao XL, Xu LY, Li KD, et al. Exploring dried ginger essential oil as a therapeutic strategy for 5-FU-induced mucositis: gut microbiota and tryptophan metabolite IAA-AHR/IL-22/STAT3 signaling axis[J]. J Ethnopharmacol, 2025, 345: 119616. DOI: 10.1016/j.jep.2025.119616.

77. Mukherjee S, Mukherjee N, Saini PM, et al. Ginger extract ameliorates phosphamidon induced hepatotoxicity[J]. Indian J Exp Biol, 2015, 53(9): 574-584. https://pubmed.ncbi.nlm.nih.gov/26548077/.

78. 王茜. 基于肥大细胞的抗过敏筛查模型的构建及其在六种食药同源食材抗过敏评估中的应用[D]. 南昌: 南昌大学, 2024. https://cdmd.cnki.com.cn/Article/CDMD-10403-1024486874.htm.