Welcome to visit Zhongnan Medical Journal Press Series journal website!
Zhongnan Medical Journal Press Series of Journals Center for Evidence-Based and Translational Medicine of Wuhan University

The title
  • The title
  • The keywords
  • The author
Submit
Home Articles Vol 27,2024 No.3 Detail

Determination of related substances in gluaric anhydride by HPLC

Published on Apr. 12, 2024Total Views: 1727 times Total Downloads: 594 times Download Mobile

Author: LIU Min 1, 2 LIAN Zhenxia 1, 2 LIU Yanxin 1, 2 WANG Fan 1, 2 LI Xia 1, 2 YANG Haixia 1, 2

Affiliation: 1. Shandong Academy of Pharmaceutical Sciences, Ji’nan 250101, China 2. Key Laboratory for Chemical Drug Research of Shandong Provincial, Ji’nan 250101, China

Keywords: Glutaric anhydride Succinic acid Adipic acid Related substances High performance liquid chromatography

DOI: 10.12173/j.issn.1008-049X.202401122

Reference: LIU Min, LIAN Zhenxia, LIU Yanxin, WANG Fan, LI Xia, YANG Haixia.Determination of related substances in gluaric anhydride by HPLC[J].Zhongguo Yaoshi Zazhi,2024, 27(3):382-387.DOI: 10.12173/j.issn.1008-049X.202401122.[Article in Chinese]

  • Abstract
  • Full-text
  • References
Abstract

Objective  To establish a method for the determination of related substances in glutaric anhydride by HPLC.

Methods  The HPLC method was performed on a Waters Symmetry C18 column (250 mm×4.6 mm, 5 µm) with mobile phase of methanol-0.1% phosphoric acid solution (3 ∶ 97) at a flow rate of 0.9 mL/min, the column temperature was 30 ℃, the injection volume was 20 μL, and the detection wavelength was set at 210 nm.

Results  Succinic acid, adipic acid and unknown impurities in glutaric anhydride can be effectively detected. The linear range was 5.925-59.251 μg/mL for succinic acid (r=0.999 6), 6.210-62.100  μg/mL for adipic acid (r=0.999 7), and 5.110-8 516.000 μg/ mL for glutaric acid (r=0.999 9). The average recoveries of succinic acid and adipic acid were 100.92% (RSD=0.86%) and 105.89% (RSD=2.99%) (n=9), respectively.

Conclusion  The method has strong specificity, high sensitivity and good accuracy, and can be used for the related substances determination of glutaric anhydride.

Full-text
Please download the PDF version to read the full text: download
References

1.Wang Z, Dupré N, Lajaunie L, et al. Effect of glutaric anhydride additive on the LiNi0.4Mn1.6O4 electrode/electrolyte interface evolution: a MAS NMR and TEM/EELS study[J]. Journal of Power Sources, 2012, 215: 170-178. DOI: 10.1016/j.jpowsour.2012.05.027.

2.陈福泉, 陈思, 洪清林, 等. 戊二酸酐酯化κ-卡拉胶的制备及理化性质[J]. 食品工业科技, 2021, 42(9): 30-35. [Chen FQ, Chen S, Hong QL, et al. Preparation and physicochemical properties of glutaric acid esterified κ-Carrageenan[J]. Science and Technology of Food Industry, 2021, 42(9): 30-35.] DOI: 10.13386/j.issn1002-0306.2020070142.

3.张翠兰, 李如梦, 胡玉娇, 等. 依折麦布的合成研究进展[J]. 山东化工, 2022, 51(24): 51-55, 58. [Zhang CL, Li RM, Hu YJ, et al. Research progress in synthesis of ezetimal[J]. Shandong Chemical Industry, 2022, 51(24): 51-55, 58.] DOI: 10.19319/j.cnki.issn.1008-021x.2022.24.057.

4.赵靓琳, 赵智伟, 陈晓杰, 等. 来那度胺的合成方法研究进展[J]. 山东化工, 2020, 49(23): 68-70, 73. [Zhao LL, Zhao ZW, Chen XJ, et al. Research progress in synthesis method of lenalidomide[J]. Shandong Chemical Industry, 2020, 49(23): 68-70, 73.] DOI: 10.19319/j.cnki.issn.1008-021x.2020.23.026.

5.殷昕, 崔美姬, 江淼, 等. 盐酸苯达莫司汀的合成[J]. 合成化学, 2016, 24(5): 457-460. [Yin X, Cui MJ, Jiang M, et al. Synthesis of bendamustine hydrochloride[J]. Chinese Journal of Synthetic Chemistry, 2016, 24(5): 457-460.] DOI: 10.15952/j.cnki.cjsc.1005-1511.2016.05.15185.

6.熊非, 陈璐, 朱元杰, 等. 普瑞巴林的合成研究进展 [J]. 合成化学, 2021, 29(2): 148-165. [Xiong F, Chen L, Zhu YJ, et al. Research advance on thesynthetic process of pregabalin[J]. Chinese Journal of Synthetic Chemistry, 2021, 29(2): 148-165.] DOI: 10.15952/j.cnki.cjsc.1005-1511.21042.

7.赵志建, 王训遒. 滴定法测定戊二酸酐的含量[J]. 化工生产与技术, 2016, 23(5): 43-45, 10. [Zhao ZJ, Wang XQ. Measuring the content of glutaric anhydride by titration method[J]. Chemical Production and Technology, 2016, 23(5): 43-45, 10.] DOI: 10.3969/j.issn.1006-6829.2016.05.014.

8.马金芬, 陈永霞, 胡迈声, 等. 戊二酸酐含量的测定[J]. 石油化工应用, 2011, 30(8): 56-58. [Ma JF, Chen YX, Hu MS, et al. Measuration for content of glutaric anhydride[J]. Petrochemical Industry Application, 2011, 30(8): 56-58.] DOI: 10.3969/j.issn.1673-5285.2011.08.018.

9.韦日伟, 王昆, 吴先富, 等. 药物中有关物质检测方法的研究进展及应用[J]. 中国药师, 2015, 18(5): 851-855. [Wei RW, Wang K, Wu XF, et al. Research advance and application of detection methods for related substances in drugs[J]. China Pharmacist, 2015, 18(5): 851-855.] DOI: 10.3969/j.issn.1008-049X.2015.05.053.

10.王云, 朱建伟. 化学合成原料药起始物料的选择原则[J]. 中国医药工业杂志, 2022, 53(5): 728-734. [Wang Y, Zhu JW. Principles for selection of starting materials for chemical synthetic API[J]. Chinese Journal of Pharmaceuticals, 2022, 53(5): 728-734.] DOI: 10.16522/j.cnki.cjph.2022.05.020.

11.杜爽, 梁毅. 化学合成原料药申报过程中起始物料的选择与控制[J]. 中国医药工业杂志, 2018, 49(8): 1172-1176. [Du S, Liang Y. Selection and control of starting materials in the process of chemical synthetic APIs submission[J]. Chinese Journal of Pharmaceuticals, 2018, 49(8): 1172-1176.] DOI: 10.16522/j.cnki.cjph.2018.08.020.

12.马帅. 混合二元酸中戊二酸的分离研究进展[J]. 当代 化工研究, 2018, (4): 42-43. [Ma S. Research progress on separation of glutaric acid from mixed dibasic acid[J]. Modern Chemical Research, 2018, (4): 42-43.] DOI: 10.3969/j.issn.1672-8114.2018.04.028.

13.庞贝. 二元酸的回收利用工艺[J]. 河南化工, 2019, 36(11): 39-40. [Pang B. Recycling process of dibasic acid[J]. Henan Chemical Industry, 2019, 36(11): 39-40.] DOI: 10.14173/j.cnki.hnhg.2019.11.012.

Popular papers
Last 6 months