Objective  To evaluate the effect of She medicine-melastoma dodecandrum water extract (MDWE) combined with imrecoxib tablet (IT) on the pain level and quality of life in patients with cervical spondylotic radiculopathy (CSR).

Methods  CSR patients admitted to Lishui Hospital of Traditional Chinese Medicine affiliated to Zhejiang TCM University from December 2021 to July 2023 were selected as study subjects. According to the treatment protocol of CSR patients, they were divided into the control group (IT, 0.1 g, po, bid, a total of 4 weeks) and combination group (IT, 0.1 g, po, bid, 4 weeks; She medicine MDWE, fumigation, 40  g,  6 times a week for 4 weeks). The treatment efficacy of CSR patients after 4 weeks of intervention, visual analog pain score (VAS) before and after 2 and 4 weeks of treatment, TCM syndrome score and hemorheological indicators before and after 4 weeks of treatment, quality of life before and after 3 months of treatment, and the incidence of adverse reactions during treatment were compared.

Results  A total of 100 CSR patients were included in the study, 52 in the combined group and 48 in the control group. After 4 weeks of treatment, the total effective rate of treatment in the combined group was significantly higher than that in the control group (P<0.05). Before treatment, the differences in VAS score, neck pain score, dyskinesia score, limb numbness score, dizziness score, back and knee weakness score, whole blood high cut viscosity, whole blood low cut viscosity, and plasma viscosity between the two groups were not statistically significant (P>0.05). After 2 weeks of treatment, the VAS scores of CSR patients in both groups decreased significantly compared with those before treatment (P<0.05), and the VAS scores of patients in the combined group were significantly lower than those in the control group (P<0.05). After 4 weeks of treatment, the above scores and blood viscosity of CSR patients in both groups were significantly lower than before treatment (P<0.05), and the above scores and blood viscosity of patients in the combined group were significantly lower than those in the control group (P<0.05). Before treatment, there was no statistically significant difference in the total scores of physiological function, somatic pain, social function, mental health, health changes, and quality of life between the two groups of CSR patients (P>0.05); After 3 months of treatment, the above scores of the two groups of CSR patients were significantly higher and the above scores of the combined group were higher than those of the control group (P<0.05). On the safety, there was no statistically significant difference in the incidence of adverse reactions during treatment between the two groups of CSR patients (P>0.05).

Conclusion  Compared with single IT treatment, She medicine MDWE combined with IT can improve the efficacy, improve the TCM syndrome score, reduce blood viscosity, improve the quality of life, and has  small adverse reactions, which is worthy of clinical promotion and application.

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