Research on the rheological properties of terbinafine hydrochloride cream

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Author: CHEN Qianqian ^1, ² LIU Zhengping ^1, ² LI Shuolei ^1, ² XUE Song ^1, ²  LI Dawei ^1, ^2, ³

Affiliation: 1. Shandong Academy of Pharmaceutical Sciences, Jinan 250108, China 2. Shandong Engineering Research Center of New Sustained and Controlled Release Formulations and Drug Targeted Delivery Systems, Jinan 250108, China 3. Key Laboratory of Pharmaceutical Preparation Technology Research and Evaluation of National Medical Products Administration, Jinan 250108, China

Keywords: Terbinafine hydrochloride cream Rheology Original drug Generic drug Yield stress Viscosity Modulus Creep recovery

DOI: 10.12173/j.issn.1008-049X.202402143

Reference: CHEN Qianqian, LIU Zhengping, XUE Song, LI Shuolei, LI Dawei.Research on the rheological properties of terbinafine hydrochloride cream[J].Zhongguo Yaoshi Zazhi,2024, 27(8):1296-1302.DOI: 10.12173/j.issn.1008-049X.202402143.[Article in Chinese]  Copied

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Abstract

Objective To study the rheological properties of terbinafine hydrochloride cream, and provide a research basis for the consistency of this product.

Methods The Kinexus rheometer was used to determine the dynamic and steady rheological parameters of terbinafine hydrochloride cream. Comparative studies on the rheological curves, yield stress, viscosity measurement, linear viscoelasticity and creep recovery of original and generic terbinafine hydrochloride cream were carried out.

Results The original and generic terbinafine hydrochloride cream were both non-Newtonian fluid with shear thinning. The yield stress of three generic were similar to the original. The linear viscoelastic region of three generic were similar to the original, and the ranges of linear viscoelastic were both 0.01%-1%, the elastic moduli were all greater than the viscosity moduli and were viscoelastic materials. It could be seen from the creep recovery curve that the creep behavior of three generic were basically the same with the original.

Conclusion Among the six terbinafine hydrochloride creams measured experimentally, the rheological properties of most generic drugs are basically the same as the original.

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