Dendrobium officinale is a Chinese herbal medicine with the same origin as medicine and food, and it is commonly used in making soup and tonic diet, etc. Dendrobium officinale and its compound preparations are widely used in clinical practice. This article used keywords such as "Dendrobium officinale" and "clinical" to search for relevant literature on clinical research on Dendrobium officinale in CNKI, Wanfang, VIP, PubMed and other databases over the past 10 years. It is found that Dendrobium officinale and its compound preparations were mainly used in the treatment of internal medicine (such as chronic gastritis, diabetes, bronchitis, hypertension, coronary heart disease, etc.), surgery, gynecology, pediatrics, ophthalmology and other diseases, and had good clinical effects. It is a Chinese herbal medicine with the development value. This article provides a comprehensive and systematic summary and analysis of the clinical application of Dendrobium officinale, aiming to provide reference for its rational clinical application and further development and research.

1.中国药典2020年版. 一部[S]. 2020: 94-97.

2.王治丹, 代云飞, 罗尚娟,等. 铁皮石斛化学成分及药理作用的研究进展[J]. 华西药学杂志, 2022, 37(4): 472-476. [Wang ZD, Dai YF, Luo SJ, et al. Research progress on chemical constituents and pharmacological effects of dendrobium officinale[J]. West China Journal of Pharmaceutical Sciences, 2022, 37(4): 472-476.] DOI: 10.13375/j.cnki.wcjps.2022.04.025.

3.Gao LL, Wang F, Hou TT, et al. Dendrobium huoshanense C.Z.Tang et S.J.Cheng: a review of its traditional uses, phytochemistry, and pharmacology[J]. Front Pharmacol, 2022, 12(13): 920823. DOI: 10.3389/fphar.2022.920823.

4.Fan C, Sun X, Wang X, et al. Therapeutic potential of the chemical composition of Dendrobium nobile Lindl[J]. Front Pharmacol, 2023, 11(14): 1163830. DOI: 10.3389/fphar.2023.1163830.

5.陈希. 用铁皮石斛辅助治疗肺阴虚干咳的疗效观察 [J]. 当代医药论丛, 2014, 12(6): 49. [Chen X.  Observation of the efficacy of Dendrobium officinale in the adjuvant treatment of lung yin deficiency and dry cough[J]. Contemporary Medical Symposium, 2014, 12(6): 49.] DOI: 10.3969/j.issn.2095-7629.2014.06.042.

6.何思陆, 梁烨, 陆高翔,等. 铁皮石斛处方辅助治疗肺结核效果的临床观察[J]. 中国医药科学, 2015, 5(10): 7-9. [He SL, Liang Y, Lu GX, et al. A clinical observation of curative effect of dendrobium offcinale prescription  in the adjuvant treatment of pulmonary tuberculosis[J]. China Medicine and Pharmacy, 2015, 5(10): 7-9.] DOI: CNKI:SUN:GYKX.0.2015-10-004.

7.张静, 李贵富. 玻璃体注药联合石斛明目丸口服对增殖型糖尿病视网膜病变患者手术治疗效果及视力的影响研究[J]. 山西医药杂志, 2022, 51(10): 1088-1091. [Zhang J, Li GF. Effect of vitreous injection combined with Shihu Mingmu Wan oral administration on surgical treatment and visual acuity of patients with proliferative diabetic retinopathy[J]. Shanxi Medical Journal, 2022, 51(10): 1088-1091.] DOI: 10.3969/j.issn.0253-9926. 2022.10.002.

8.龙太荣. 石斛滋阴生津方联合消渴丸治疗2型糖尿病临床疗效观察[J]. 中国处方药, 2021, 19(7): 150-152. [Long TR. Observation on the clinical efficacy of Dendrobium Ziyin Shengjin Fang combined with thirst pills in the treatment of type 2 diabetes[J]. Chinese Prescription Drug, 2021, 19(7): 150-152.] DOI: 10.3969/j.issn.1671-945X.2021.07.071.

9.苏晓燕, 施红, 吴建珊, 等. 石斛合剂序贯方不同剂型治疗2型糖尿病临床疗效比较[J]. 中华中医药杂志, 2015, 30(6): 2233-2235. [Su XY, Shi H, Wu JS, et  al. Curative effect comparison on different dosage forms of Dendrobium Mixture Sequential Formula[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2015, 30(6): 2233-2235.] DOI: CNKI:SUN:BXYY.0.2015-06- 112.

10.齐乐. 石斛破壁草本联合奥美拉唑治疗慢性萎缩性胃炎的临床疗效观察[J]. 药物评价研究, 2022, 45(6): 1141-1145. [Qi L. Clinical observation of breaking cell wall herb of Dendrobii Caulis combined with omeprazole in treatment of chronic atrophic gastritis[J]. Drug Evaluation Research, 2022, 45(6): 1141-1145.] DOI: 10.7501/j.issn. 1674-6376.2022.06.018.

11.尹意婷, 鲁月琴, 何月敏. 石斛养胃汤联合奥美拉唑肠溶胶囊对慢性萎缩性胃炎患者炎症因子及氧化应激水平的影响[J]. 新中医, 2022, 54(5): 108-112. [Yin YT, Lu YQ, He YM. Effects of Shihu Yangwei Tang combined with omeprazole enteric-soluble capsules on inflammatory factors and oxidative stress levels in patients with chronic atrophic gastritis[J]. New Chinese Medicine, 2022, 54(5): 108-112.] DOI: 10.13457/j.cnki.jncm.2022.05.024.

12.李容. 石斛养胃汤联合西药治疗慢性萎缩性胃炎的临床效果[J]. 内蒙古中医药, 2022, 41(12): 18-19. [Li  R. Clinical effect of Shihu Yangwei decoction combined with western medicine in the treatment of chronic atrophic gastritis[J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2022, 41(12): 18-19.] DOI: 10.16040/j.cnki.cn15-1101.2022.12.047.

13.吴玉, 蔡敏, 张丽, 等. 石斛养胃汤联合胶体果胶铋干混悬剂及阿莫西林对慢性萎缩性胃炎胃功能及血清炎性因子影响研究[J]. 中华中医药学刊, 2019, 37(8): 1986-1990. [Wu Y, Cai M, Zhang L, et al. Effect of Shihu Yangwei decoction combined with collidal bismuth pectin for suspension and amoxicillin on gastric function and serum inflammatory factors in patients with chronic atrophic gastritis[J]. Chinese Archives of Traditional Chinese Medicine, 2019, 37(8): 1986-1990.] DOI: 10.13193/j.issn.1673-7717.2019.08.047.

14.陆春雷, 潘兴寿, 黄春合, 等. 石斛辅助治疗HBeAg阳性慢性乙型肝炎疗效观察[J]. 时珍国医国药, 2014, 25(11): 2698-2770. [Lu CL, Pan XS, Huang CH, et al. Traditional Chinese medicine (Dendrobium officinale Kimura et Migo) in the treatment of HBeAg positive patients with chronic hepatitis b clinical curative effect observation[J]. Lishizhen Medicine and Materia Medica Research, 2014, 25(11): 2698-2770.] DOI: 10.3969/j.issn. 1008-0805.2014. 11.052.

15.吴俊, 庄煌辉, 毛志田, 等. 龙虎山铁皮石斛治疗高血压病临床观察[J]. 中医药临床杂志, 2018, 30(2): 297-299. [Wu J, Zhuang HH, Mao ZT, et al. Clinica observation of Dendrobium candidum in Mount Longhu in the treatment of hypertension[J]. Clinical Journal of Traditional Chinese Medicine, 2018, 30(2): 297-299.] DOI: 10.16448/j.cjtcm.2018.0088.

16.邹玉卿, 张家林, 刘欣, 等. 石斛合剂序贯法联合西药治疗糖尿病合并高血压的影响[J]. 亚太传统医药, 2021, 17(1): 48-51. [Zou YQ, Zhang JL, Liu X, et al. Effect of DMOC with western medicine in diabetes with hypertension[J]. Asia-Pacific Traditional Medicine, 2021, 17(1): 48-51.] DOI: 10.11954/ytctyy.202101014.

17.李德祥, 王学涵, 李路, 等. 霍山石解组方治疗冠心病的临床研发与应用[J]. 中国医药指南, 2014, 12(13): 314-315. [Li DX, Wang XH, Li L, et al. Clinical development and application of Huoshan Shijie formula for the treatment of coronary heart disease[J]. Guide of China Medicine, 2014, 12(13): 314-315.] DOI: 10.015912/j.cnki.gocm.2014.13.142.

18.王勉. 铁皮石斛联合西药治疗冠心病心绞痛的临床应用[D]. 杭州: 浙江中医药大学, 2020. DOI: 10.27465/d.cnki.gzzyc.2020.000071.

19.李鹏, 吕计宝, 熊广明. 自拟石斛牛膝汤治疗膝关节骨性关节炎198例[J]. 健康之路, 2017, 16(5): 244. [Li P, Lyu JB, Xiong GM. 198 cases of knee osteoarthritis were treated with self-simulated Dendrobium hyssop soup[J]. Health Way, 2017, 16(5): 244.] DOI: 10.3969/j.issn.1671-8801.2017.05.323.

20.顾明年. 石斛玉女煎联合艾拉莫德治疗胃热阴虚型干燥综合征临床疗效及安全性观察[D]. 山西晋中: 山西中医药大学, 2020. DOI: 10.27820/d.cnki.gszxy.2020.000261.

21.刘一超, 孙淑娜. 麦冬石斛洗剂治疗血虚风燥型特应性皮炎临床观察[J]. 山西中医, 2023, 39(3): 47- 48. [Liu YC, Sun SN. Clinical observation of Dendrobium officinale lotion in the treatment of atopic dermatitis with blood deficiency and wind dryness[J]. Shanxi Journal of Traditional Chinese Medicine, 2023, 39(3): 47-48.] DOI: 10.20002/j.issn.1000-7156.2023.03.019.

22.钟良. 石斛本草面膜治疗面部皮肤干燥的临床疗效观察[D]. 长沙: 湖南中医药大学, 2023. DOI: 10.27138/d.cnki.ghuzc.2022.000313.

23.曾德创, 邹才华, 李近都, 等. 石斛治疗血栓闭塞性脉管炎患者炎症细胞因子变化的观察[J]. 中国医药科学, 2016, 6(21): 9-12, 17. [Zeng DC, Zou CH, Li JD, et al. Observation changes of inflammatory cytokines in patients with thrombotic obliterans treated by dendrobium[J]. China Medicine and Pharmacy, 2016, 6(21): 9-12, 17.] DOI: 10.3969/j.issn.2095-0616.2016.21.003.

24.陈莹, 李红, 马坤, 等. 鲜石斛联合促卵合剂治疗肾阴不足型卵泡发育不良不孕症临床研究[J]. 福建中医药, 2021, 53(3): 7-9. [Chen Y, Li H, Ma K, et al.  Fresh Dendrobium combined with Culuan Heji treatment for follicular maldevelopment infertility with kidney yin deficiency syndrom[J]. Fujian Journal of Traditional Chinese Medicine, 2021, 53(3): 7-9.] DOI: 10.13260/j.cnki.jfjtcm.012192.

25.程志源, 邹国斌, 吴苏柳, 等. 鲜铁皮石斛佐治小儿顽固性发热53例疗效观察[J]. 浙江中医杂志, 2017, 52(8): 592. [Cheng ZY, Zou GB, Wu SL, et al. The efficacy of Dendrobium officinale in children with refractory fever was observed in 53 cases[J]. Zhejiang Journal of Traditional Chinese Medicine, 2017, 52(8): 592.] DOI: 10.3969/j.issn. 0411-8421.2017.08.030.

26.钱雄, 李宗起, 唐桂亚. 石斛代茶饮治疗小儿便秘50例临床观察[J]. 浙江中医杂志, 2016, 51(6): 433. [Qian X, Li ZQ, Tang GY. Clinical observation of 50 cases of constipation in children treated with Dendrobium tea instead of tea[J]. Zhejiang Journal of Traditional Chinese Medicine, 2016, 51(6): 433.] DOI: 10.13633/j.cnki.zjtcm. 2016.06.029.

27.曲燕磊, 张唯. 石斛夜光丸配合按摩治疗视疲劳的临床观察[J]. 现代中医药, 2017, 37(5): 63-64. [Qu YL, Zhang W. Clinical observation of Dendrobium luminous pills combined with massage in the treatment of visual fatigue[J]. Modern Traditiona1 Chinese Medicine, 2017, 37(5): 63-64.] DOI: 10.13424/j.cnki.mtcm.2017.05.024.

28.唐芸. 赤水金钗石斛治疗糖尿病视网膜病变的疗效研究[D]. 贵州遵义: 遵义医科大学, 2022. DOI: 10.27680/d.cnki.gzyyc.2022.000480.

29.商玉萍, 汪洋奎, 王欣晨, 等. 鲜石斛制剂对肿瘤放化疗致口腔黏膜损伤的临床疗效观察 [J]. 肿瘤药学, 2021, 11(3): 350-353. [Shang YP, Wang YK, Wang XC, et al. Clinical efficacy of fresh Dendrobium preparation against oral mucosal injury caused by tumor chemoradiotherapy[J]. Anti-tumor Pharmacy, 2021, 11(3): 350-353.] DOI: 10.3969/j.issn.2095-1264. 2021.03.19.

30.蓝云英. 石斛联合针刺治疗鼻咽癌放疗口干症的临床研究[D]. 广州: 广州中医药大学, 2018. DOI: CNKI: CDMD: 2.1018.272917.

31.潘静. 石斛夜光丸治疗足跟痛45例临床疗效观察[J]. 中国医药指南, 2013, 11(28): 484. [Pan J. Clinical efficacy of Dendrobium luminous pill in the treatment of heel pain in 45 cases[J]. Guide of China Medicine, 2013, 11(28): 484.] DOI: 10.3969/j.issn.1671-8194.2013.28.390.