Diarrhea is the most common clinical symptom of the digestive system, its pathogenesis may be related to intestinal infection, intestinal microecological instability,  intestinal barrier dysfunction and so on. Sijunzi decoction has the effect of invigorating spleen and nourishing stomach, and supplementing qi and blood. In modern clinical practice, modified Sijunzi decoction combining with other prescriptions, Chinese medicine massage, acupuncture and western medicine attenuates synergies, improves the patients' quality of life, and is widely  used in the treatment of diarrhea, but its mechanism has not yet been systematically clarified. Therefore, this article reviews the research progress of the mechanism and clinical application of Sijunzi decoction and its modified formula in the treatment of diarrhea, and provides reference for the mechanism research and prevention of Sijunzi decoction and its modified formula in the treatment of diarrhea.

1.黄燕. 古今腹泻医案要素及诊疗规律研究[D]. 北京: 中国中医科学院, 2022. DOI: 10.27658/d.cnki.gzzyy. 2021.000111.

2.张慰. 脾肾亏虚型泄泻的中医辨证治疗[J]. 智慧健康, 2022, 8(2): 23-25. [Zhang W. Treatment of diarrhea of deficiency of spleen and kidney with TCM syndrome differentiation[J]. Smart Healthcare, 2022, 8(2): 23-25.] DOI: 10.19335/j.cnki.2096-1219.2022.02.008.

3.路漫漫, 鞠宝兆. 中医外治法在泄泻治疗中应用探讨 [J]. 辽宁中医药大学学报, 2017, 19(1): 95-97. [Lu MM, Ju BZ. Application of external use of TCM in the treatment of diarrhea[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2017, 19(1): 95-97.] DOI: 10.13194/j.issn.1673-842x.2017.01.028.

4.杨珊, 赵暖暖, 杨鑫, 等. 人参活性成分及药理作用研究进展[J]. 中医药导报, 2023, 29(1): 105-107, 116.[Yang S, Zhao NN, Yang X, et al. Research progress on active ingredients and pharmacological effects of Renshen (Ginseng)[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacology, 2023, 29(1): 105-107, 116.] DOI: 10.13862/j.cn43-1446/r.2023.01.019.

5.刘棣文, 何莉莉, 崔娜, 等. 白术化学成分、药理作用研究进展及质量标志物预测[J]. 中医药信息, 2024, 41(1): 65-78. [Liu DW, He LL, Cui N, et al. Research progress of chemical constituents,pharmacological action and quality marker prediction of Largehead atractylodes rhizome[J]. Information on Traditional Chinese Medicine, 2019, 41(1): 65-78.] DOI: 10.19656/j.cnki.1002- 2406.20240113.

6.吕黎明, 张来宾, 吕洁丽. 茯苓的化学成分、药理作用及临床应用[J]. 滨州医学院学报, 2024, 47(1): 61-67. [Lyu LM, Zhang LB, Lyu JL. Chemical constituents, pharmacological effects and clinical applications of Poriacocos[J]. Journal of Binzhou Medical University, 2019, 47(1): 61-67.] DOI: 10.19739/j.cnki.issn1001-9510.2024.01.013.

7.谢瑞强, 王长福. 炙甘草化学成分和药理作用研究进展[J]. 中医药信息, 2023, 40(4): 84-89. [Xie RQ, Wang CF. Research progress on chemical constituents and pharmacological effects of prepared Glycyrrhiza[J]. Information on Traditional Chinese Medicine, 2023, 40(4): 84-89.] DOI: 10.19656/j.cnki.1002-2406.20230414.

8.李晓彤, 康楠, 李家立, 等. 肠道菌群与功能性腹泻中医药研究进展[J]. 辽宁中医药大学学报, 2023, 25(12): 60-65. [Li XT, Kang N, Li JL, et al. Research progress of gut microflora, functional diarrhea and traditional Chinese medicine[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2023, 25(12): 60-65.] DOI: 10.13194/j.issn.1673-842x.2023.12.013.

9.杨利桃, 李悦山, 周毅, 等. 加味四君子汤对脾虚泄泻大鼠肠道菌群及sIgA的影响[J]. 上海中医药杂志, 2011, 45(12): 85-87. [Yang LT, Li YS, Zhou Y, et al. Effects of“Sijunzi Decoction”on sIgA and gut flora in rats with spleen-deficiency diarrhea[J]. Shanghai Journal of Traditional Chinese Medicine, 2011, 45(12): 85-87.] DOI: 10.16305/j.1007-1334.2011.12.031.

10.邹孟龙, 宁芯, 陈雅璐, 等. 四君子汤介导肠道黏膜屏障防治溃疡性结肠炎的研究进展[J]. 中医药导报, 2020, 26(10): 134-137. [Zou ML, Ning X, Chen YL, et al. Research progress of Sijunzi decoction mediated intestinal mucosal barrier in the prevention and treatment of ulcerative colitis[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacolog, 20, 26(10): 134-137.] DOI: 10.13862/j.cnki.cn43-1446/r.2020.10.032.

11.左旭. 人参挥发油的抗炎活性研究[D]. 长春: 吉林大学, 2021. DOI: 10.27162/d.cnki.gjlin.2021.002876.

12.张小亮. 加味四君子汤调控ITP小鼠Jak/Stat3/RORγt信号通路抑制Th17活化的作用机制研究[D]. 沈阳: 辽宁中医药大学, 2021. DOI: 10.27213/d.cnki.glnzc.2021. 000586.

13.魏海涛, 方秋华, 张炳顺, 等. 白术有效成分及药理作用研究进展[J]. 广东畜牧兽医科技, 2022, 47(6): 40-44, 51. [Wei HT, Fang QH, Zhang BS, et al. Research progress on the effective ingredients and pharmacological effects of Atractylodes macrocephala[J]. Guangdong Journal of Animal and Veterinary Science, 202, 47(6): 40-44, 51.] DOI: 10.19978/j.cnki.xmsy.2022.06.08.

14.刘芳, 魏先鹏, 唐学贵. 四君子汤加减对肠易激综合征患者5-HT3受体、5-HT4受体及炎症指标的影响[J]. 中药材, 2021, 44(1): 215-218. DOI: 10.13863/j.issn1001-4454.2021.01.041.

15.Yu QW, Yan FZ, Xiao LW, et al. Ginseng-containing Sijunzi decoction ameliorates ulcerative colitis by orchestrating gut homeostasis in microbial modulation and intestinal barrier integrity[J]. Am J Chin Med, 2023, 51(3): 677-699. DOI: 10.1142/S0192415X23500325.

16.涂小华, 杨欣, 杨光勇, 等. 四君子汤对IEC-6细胞增殖相关指标及大鼠胃肠黏膜c-Myc表达的影响[J]. 中药新药与临床药理, 2022, 33(2): 143-150. [Tu XH, Yang  X, Yang GY, et al. Effects of Sijunzi decoction on IEC-6 cell proliferation related index and c-Myc expression in gastrointestinal mucosa of rats[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 202, 33(2): 143-150.] DOI: 10.19378/j.issn.1003-9783.2022.02.001.

17.罗蒙. 从Ca2+调节及细胞连接角度探讨四君子汤多糖肠黏膜保护作用[D]. 广州: 广州中医药大学, 2021. DOI: 10.27044/d.cnki.ggzzu.2021.000529.

18.刘琴, 周赛男, 刘杰民, 等. 基于自噬探讨健脾益肠散对溃疡性结肠炎模型大鼠肠黏膜保护的作用机制 [J]. 中药新药与临床药理, 2024, 35(6): 814-821. [Liu Q, Zhou SN, Liu JM, et al. The mechanism of protective effect of Jianpi Yichang powder on intestinal mucosa of rats with ulcerative colitis based on autophagy[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2019, 35(6): 814-821.] DOI: 10.19378/j.issn.1003-9783.2024. 06.006.

19.高蓓蓓, 彭颖, 李晓波. 四君子汤复方多糖肠道免疫调节作用及其机制研究进展[J]. 中草药, 2018, 49(2): 462-467. [Gao BB, Peng Y, Li XB. Research progress on intestinal immunoregulation and mechanism of Sijunzi decoction polysaccharide[J]. Chinese Traditional and Herbal Drugs, 2018, 49(2): 462-467.] DOI: 10.7501/j.issn.0253-2670.2018.02.030.

20.翟林, 刘伟, 熊健康, 等. 四君子汤加减联合肠内营养对胃癌患者术后免疫功能影响的荟萃分析[J]. 广州中医药大学学报, 2023, 40(5): 1301-1308. [Zhai L, Liu  W, Xiong JK, et al. Effect of Sijunzi decoction combined with enteral nutrition on immune function of postoperative patients with gastric cancer: a Meta-analysis[J].Journal of Guangzhou University of Traditional Chinese Medicine, 2023, 40(5): 1301-1308.] DOI: 10.13359/j.cnki.gzxbtcm. 2023.05.040.

21.Guang Z, Wang M, Cai Y, et al. Rapid characterization of the chemical constituents of Sijunzi decoction by UHPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry[J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2018, 1086: 11-22. DOI: 10.1016/j.jchromb.2018.04.009.

22.An K, Jin-Rui G, Zhen Z, et al. Simultaneous quantification of ten active componentsin traditional Chinese formula Sijunzi decoction using a UPLC-PDA method[J]. J Anal Methods Chem, 2014, 2014(1): 570359. DOI: 10.1155/2014/570359.

23.Dong B, Peng C, Ma P, et al. An integrated strategy of MS-network-based offline 2DLC-QTOF-MS/MS coupled with UHPLC-QTRAP®-MS/MS for the characterization and quantification of the non-polysaccharides in Sijunzi decoction[J]. Anal Bioanal Chem, 2021, 413(13): 3511-3527. DOI: 10.1007/s00216-021-03302-x.

24.张羽, 黄美祯, 潘春曲, 等. 四君子汤有效化学成分以及防治消化系统疾病机制研究进展[J]. 海南医学院学报, 2023, 29(7): 554-560. [Zhang Y, Huang MZ, Pan CQ, et al. Research progress on effective chemical constituents of Sijunzi decoction and mechanism of prevention and treatment of digestive system diseases[J]. Journal of Hainan Medical University, 2019, 29(7): 554-560.] DOI: 10.13210/j.cnki.jhmu.20210709.001.

25.王鄂明, 符克燕, 齐若谷. 四君子汤联合肠内营养对结肠癌手术免疫功能及血清IL-2、IL-6水平的影响 [J]. 实用中医内科杂志, 2021, 35(1): 66-69. [Wang EM, Fu KY, Qi RG. Effects of Sijunzi decoction combined with immunity and serum levels of IL-2 and IL-6 in patients undergoing colorectal cancer surgery[J]. Journal of Practical Traditional Chinese Internal Medicine, 2021, 35(1): 66-69.] DOI: 10.13729/j.issn.1671-7813.Z20200100.

26.崔爱珍. 探究用四君子汤加减方治疗脾胃气虚型胃溃疡合并功能性消化不良的效果[J]. 世界最新医学信息文摘, 2019, 19(89): 210-211. DOI: 10.19613/j.cnki. c1671-3141.2019.89.136.

27.殷桃花. 四君子汤加减治疗溃疡性结肠炎的效果[J]. 内蒙古中医药, 2022, 41(6): 37-38. DOI: 10.16040/j.cnki.cn15-1101.2022.06.010.

28.黄春风, 杨先玉. 四君子汤加减治疗老年胃癌术后化疗患者消化道毒副反应临床观察[J]. 临床医药文献电子杂志, 2020, 7(45): 157, 159. DOI: 10.16281/j.cnki.jocml.2020.45.109.

29.李阳, 任顺平, 侯雪玥. 任顺平应用“五位一体”理论治疗泄泻经验总结[J]. 中国民间疗法, 2024, 32(8): 48-51. DOI: 10.19621/j.cnki.11-3555/r.2024.0815.

30.王静, 钟伟, 张海华, 等. 白芍总苷在治疗溃疡性结肠炎中作用及机制的研究进展[J]. 中药材, 2022, 45: 1282-1286. [Wang J, Zhong W, Zhang HH, et al. Research progress on the effect and mechanism of total glucosides of paeony in the treatment of ulcerative colitis[J]. Journal of Chinese Medicinal Materials, 2022, 45: 1282-1286.] DOI: 10.13863/j.issn1001-4454.2022.05.045.

31.杨杰, 张丽曼, 王丽丽, 等. 清肠化瘀方治疗溃疡性结肠炎疗效及对IDO、Treg/Th17平衡的影响[J]. 广州中医药大学学报, 2023, 40(5): 1642-1648. [Yang J, Zhang LM, Wang LL, et al. Clinical efficacy of qingchang huayu prescription in the treatment of ulcerative colitis and its effect on IDO and Treg/Th17 balance[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2023, 40(5): 1642-1648.] DOI: 10.13359/j.cnki.gzxbtcm. 2023.07.010.

32.刘琴, 周赛男, 刘杰民, 等. 基于自噬探讨健脾益肠散对溃疡性结肠炎模型大鼠肠黏膜保护的作用机制 [J]. 中药新药与临床药理, 2024, 35(6): 814-821. [Liu Q, Zhou SN, Liu JM, et al. The mechanism of protective effect of Jianpi Yichang powder on intestinal mucosa of rats with ulcerative colitis based on autophagy[J]. Traditional Chinese Drug Research and Clinical Pharmacology, 2019, 35(6): 814-821.] DOI: 10.19378/j.issn.1003-9783.2024.06.006.

33.陈斯. 延胡索化学成分和药理作用研究进展[J]. 中医药信息, 2021, 38(7): 78-82. [Chen S. Research progress on chemical constituents and pharmacological effects of Corydalis rhizoma[J]. Lnformation on Traditional Chinese Medicine, 2021, 38(7): 78-82.] DOI: 10.19656/j.cnki. 1002-2406.20210716.

34.郝瑞, 张莉莉, 顾成娟, 等. 薏苡仁、莲子、芡实治疗脾虚泄泻经验——仝小林三味小方撷萃[J]. 吉林中医药, 2020, 40(8): 992-994. [Hao R, Zhang LL, Gu CJ, et al. Experience in treating diarrhea due to spleen deficiency with Coix seed, Lotus seed and Euryale seed——three prescription by professor TONG Xiaolin[J]. Jilin Journal of Traditional Chinese Medicine, 2020, 40(8): 992-994.] DOI: 10.13463/j.cnki.jlzyy.2020.08.004.

35.冯文林, 肖炜. 基于《黄帝内经》谈五运六气对泄泻发病和诊治的启示[J]. 辽宁中医药大学学报, 2023, 25(8): 162-165. [Feng WL, Xiao W. Enlightenment of five movements and six qi on diarrhea and its diagnosis and treatment based on Inner Canon of Huangdi[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2023, 25(8): 162-165.] DOI: 10.13194/j.issn.1673-842x.2023. 08.035.

36.史晨旭, 杜佳蓉, 吴威, 等. 葛根化学成分及药理作用研究进展[J]. 中国现代中药, 2021, 23(12): 2177-2195. [Shi CX, Du JR, Wu W, et al. Chemical constituents and pharmacological action of Puerariae lobatae radix: a review[J]. Modern Chinese Medicine, 2019, 23(12): 2177-2195.] DOI: 10.13313/j.issn.1673-4890.20200918004.

37.顾娟红. 自拟温阳止泻汤联合穴位贴敷治疗脾肾阳虚型泄泻效果观察[J]. 基层中医药, 2024, 3(6): 34-38. [Gu  JH. Clinical efficacy of self-prescribed Wenyang Zhixie decoction combined with acupoint application on diarrhea with spleen and kidney yang deficiency syndrome[J]. Basic Traditional Chinese Medicine, 2019, 3(6): 34-38.] DOI: 10.20065/j.cnki.btcm.20240117.

38.张媛媛, 彭智祥, 陈超, 等. 基于中医药配伍理论吴茱萸有效成分含量测定及配比关系研究[J]. 实用中西医结合临床, 2022, 22(13): 122-128. [Zhang YY, Peng  ZX, Chen C, et al. Study on the content determination and proportioning relationship of effective components in Evodia Rutaecarpa based on the compatibility theory of traditional Chinese medicine[J]. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine, 2012, 22(13): 122-128.] DOI: 10.13638/j.issn.1671-4040.2022.13.034.

39.张胜男. 化湿止泻方治疗腹泻型肠易激综合征(IBS-D)脾胃湿热证的临床研究[D]. 济南: 山东中医药大学, 2024. DOI: 10.27282/d.cnki.gsdzu.2023.000708.

40.王婉怡, 朱志军, 李航飞, 等. 半夏化学成分、药理作用研究进展及其质量标志物预测分析[J]. 辽宁中医药大学学报, 2024, 26(3): 203-215. [Wang WY, Zhu ZJ, Li HF, et al. Research progress on chemical constituents and pharmacological effects of Banxia (Pinelliae rhizoma) and prediction analysis of quality markers[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2024, 26(3): 203-215.] DOI: 10.13194/j.issn.1673-842x.2024.03.043.

41.邵好青. 保和丸水煎液对食滞胃肠型泄泻小鼠肠道微生态的作用机制研究[D]. 长沙: 湖南中医药大学, 2022. DOI: 10.27138/d.cnki.ghuzc.2022.000004.

42.靳庆霞. 浅析山楂的化学成分及药理作用[J]. 内蒙古中医药, 2014, 33(36): 62. DOI: 10.3969/j.issn. 1006-0979.2014.36.065.

43.Shang L,Wang Y,Li J,et al. Mechanism of Sijunzi decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation[J]. J Ethnopharmacol, 2023, 302(Pt A): 115876. DOI: 10.1016/j.jep.2022.115876.

44.谢坚冰. 四君子汤加味治疗脾虚型小儿腹泻临床效果 [J]. 内蒙古中医药, 2020, 39(4): 52-53. DOI: 10.16040/j.cnki.cn15-1101.2020.04.030.

45.谢兰星, 刘艳梅. 四君子汤加味治疗脾虚型婴儿腹泻临床疗效观察[J]. 实用中西医结合临床, 2018, 18(11): 98-99. DOI: 10.13638/j.issn.1671-4040.2018.11.047.

46.王韵, 刁娟娟, 陈鲁. 四君子汤类方治疗小儿泄泻脾虚证[J]. 吉林中医药, 2021, 41(11): 1532-1535. [Wang  Y, Diao JJ, Chen L. An experience summary of Sijunzi decoction in treating infantile diarrhea with the spleen deficiency syndrome[J]. Jilin Journal of Traditional Chinese Medicine, 2021, 9(11): 1532-1535.] DOI: 10.13463/j.cnki.jlzyy.2021.11.033.

47.吴宝麒. 基于四君子汤的复方谷氨酰胺肠溶胶囊治疗腹泻型肠易激综合征的随机双盲对照研究[D]. 北京: 中国中医科学院, 2022. DOI: 10.27658/d.cnki.gzzyy. 2022.000120.

48.王韵. 基于真实世界探讨四君子汤类方治疗小儿泄泻脾虚证的用药规律研究[D]. 济南: 山东中医药大学, 2022. DOI: 10.27282/d.cnki.gsdzu.2022.000097.

49.赵元辰, 张淑坤, 关鑫, 等. 柴芩四君子汤对胆囊切除术后患者肠道菌群的影响[J]. 中国中西医结合外科杂志, 2022, 28(5): 695-701. [Zhao YC, Zhang  SK, Guan Xin, et al. Effects of Chaiqin Sijunzi decoction on intestinal flora of patients after cholecystectomy[J]. Chinese Journal of Surgery of Integrated Traditional and Western Medicine, 2022, 28(5): 695-701.] DOI: 10.3969/j.issn.1007-6948.2022.05.019.

50.顾景辉, 李忠. 四君子汤加味治疗腹泻型肠易激综合征临床疗效及对生活质量的影响[J]. 空军医学杂志, 2020, 36(1): 79-82. [Gu JH, Li Z. Effect of Sijunzi decoction on diarrhea-predominant irritable bowel syndrome and quality of life[J]. Aviation Medicine of Air Force, 20, 36(1): 79-82.] DOI: 10.3969/j.issn.2095-3402.2020.01.023.

51.方妹辉, 王文峰, 司会强. 四君子汤合痛泻要方加减治疗肝郁脾虚型慢性腹泻的临床疗效分析[J]. 医学理论与实践, 2021, 34(1): 7-9. [Fang MH, Wang WF, Si HQ. Clinical Effect of modified Sijunzi decoction and Tongxie recipe in the treatment of chronic diarrhea with stagna-tion of liver qi and spleen deficiency[J]. The Journal of Medical Theory and Practice, 21, 34(1): 7-9.] DOI: 10.19381/j.issn.1001-7585.2021.01.003.

52.向建国. 痛泻要方合四君子汤治疗胆囊切除术后腹泻的临床效果[J]. 内蒙古中医药, 2021, 40(9): 82-83. DOI: 10.16040/j.cnki.cn15-1101.2021.09.050.

53.王占风. 小柴胡汤合四君子汤治疗胆囊术后腹泻94例 [J]. 光明中医, 2016, 31(17): 2489-2491. DOI: 10.3969/j.issn.1003-8914.2016.17.017.

54.周丽娜, 朱涛. 补中益气汤合四君子汤治疗慢性腹泻的临床疗效[J]. 内蒙古中医药, 2020, 39(7): 25-26. DOI: 10.16040/j.cnki.cn15-1101.2020.07.015.

55.谢依名. 加味四君子合芍药汤治疗肿瘤化疗所致腹泻的效果观察[J]. 人人健康, 2019, (12): 105-106. DOI: CNKI:SUN:RRJK.0.2019-12-119.

56.胡丹. 中医推拿联合自拟四君子汤直肠滴注治疗小儿β-内酰胺类抗菌药物相关性腹泻的疗效及对肠道菌群和免疫功能影响[J]. 现代中西医结合杂志, 2018, 27(5): 488-491. [Hu D. Curative effect of TCM massage combined with Sijunzi Decoction by rectum drip on infantile diarrhea induced by β-Lactam antibiotics, and the effect on intestinal flora and immune function[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2018, 27(5): 488-491.] DOI: 10.3969/j.issn.1008-8849.2018.05.009.

57.徐佐朋. 中药配合针刺治疗功能性腹泻临床研究 [J]. 新中医, 2009, 41(7): 93-94. DOI: 10.13457/j.cnki.jncm. 2009.07.035.

58.章新辉, 吴飒. 四君子汤联合益生菌治疗小儿腹泻42例[J]. 中国中医药现代远程教育, 2019, 17(9): 109-111. [Zhang XH, Wu S. Sijunzi decoction combined with probiotics in the treatment of diarrhea in children for 42 cases[J]. Chinese Medicine Modern Distance Education of China, 2019, 17(9): 109-111.] DOI: 10.3969/j.issn.1672-2779.2019.09.043.

59.徐拥军. 四君子汤佐治婴幼儿β-内酰胺类抗生素相关性腹泻疗效观察[J]. 浙江中西医结合杂志, 2015, 25(2): 162-163. DOI: 10.3969/j.issn.1005-4561.2015.02.028.

60.经双双, 何宗卿, 郑雪, 等. 中医药治疗溃疡性结肠炎的代谢组学研究进展[J]. 中医学报, 2023, 38(7): 1386-1394. [Jing SS, He ZQ, Zheng X, et al. Research progress on metabolomics of TCM treatment of ulcerative colitis[J]. China Journal of Chinese Medicine, 2023, 38(7): 1386-1394.] DOI: 10.16368/j.issn.1674-8999.2023.07.228.

61.赵梦健, 任慧娟, 周小魏, 等. 人参皂苷Re磷脂复合物的制备及其体外释放和体内药动学评价[J/OL]. 烟台大学学报(自然科学与工程版), 2024-06-20. [Zhao MJ, Ren HJ, Zhou XW, et al. Preparation of ginsenoside Re phospholipid complex and evaluation of its in vitro release and in vivo pharmacokinetic[J/OL]. Journal of Yantai University (Natural Science and Engineering Edition), 2024-06-20.] DOI: 10.13951/j.cnki.37-1213/n.240202.

62.申佳林, 赵小莹, 肖海娟. 四君子汤及其主要有效成分抗结直肠癌机制研究进展[J]. 中国实验方剂学杂志, 2024, 30(16): 240-252. [Shen JL, Zhao XY, Xiao HJ. Mechanisms of Si Junzitang and its main active components in treating colorectal cancer: a review[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2024, 30(16): 240-252.] DOI: 10.13422/j.cnki.syfjx.20241224.