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Research progress on active ingredients and pharmacological effects of Smilacis chinae rhizoma

Published on Oct. 15, 2024Total Views: 950 times Total Downloads: 138 times Download Mobile

Author: YE Xiaoyan 1, 2 WANG Yuying 1, 2 ZHANG Xueling 1, 2 CHEN Ali 1, 2

Affiliation: 1. Center for Drug Research and Development of Guangdong Pharmaceutical University, Guangzhou 510006, China 2. Guangdong Provincial Key Laboratory of Advanced Drug Delivery System, Guangzhou 510006, China

Keywords: Smilacis chinae rhizoma Active ingredients Steroidal saponins Flavonoids Phenols Stilbenes Organic acids Pharmacological effect Development and utilization Research progress

DOI: 10.12173/j.issn.2097-4922.202404156

Reference: YE Xiaoyan, WANG Yuying, ZHANG Xueling, CHEN Ali.Research progress on active ingredients and pharmacological effects of Smilacis chinae rhizoma[J].Yaoxue QianYan Zazhi,2024, 28(1):124-132.DOI: 10.12173/j.issn.2097-4922.202404156.[Article in Chinese]

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Abstract

As a kind of traditional Chinese medicine, which has a medicinal site of rhizomes, contains rich active ingredients, mainly including steroidal saponins, flavonoids, phenols, stilbenes, organic acids and other compounds, which together give a wide range of pharmacological effects, including anti-inflammatory, antibacterial, anti-tumor, hypolipidemic, hypoglycemic, and so on. In recent years, with the continuous development of modern science and technology, the research on Smilacis chinae rhizoma has been deepening, and the pharmacological mechanism of its active ingredients has been gradually revealed. This paper reviews the research progress on the active ingredients and pharmacological effects of Smilacis chinae rhizoma over the last few years at home and abroad, in order to provide a scientific basis for further development and utilization of Smilacis chinae rhizoma, and inject new vitality into the modernization and international development of traditional Chinese medicine.

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References

1.杨琳琳. 菝葜多糖改善对乙酰氨基酚诱导小鼠急性肝损伤的作用及机制研究[D]. 武汉: 华中科技大学, 2021. DOI: 10.27157/d.cnki.ghzku.2021.005485.

2.曾晓霞, 陈锡林. 菝葜传统应用和现代研究概况[J]. 中草药, 2008, 39(6): 952-954. DOI: 10.3321/j.issn: 0253-2670.2008.06.049.

3.中国药典2020年版. 四部[S]. 2020: 321-322.

4.王福燕, 江丰, 范小龙, 等. 基于化学成分药理作用及网络药理学的菝葜质量标志物预测分析[J]. 时珍国医国药, 2022, 33(11): 2805-2809. [Wang FY, Jiang F, Fan XL, et. Prediction and analysis of quality markers of Smilax china based on pharmacological action of chemical constituents and network pharmacology[J]. Lishizhen Medicine and Materia Medica Research, 2022, 33(11): 2805-2809.] DOI: 10.3969/j.issn.1008-0805.2022.11.74.

5.Ru JL, Li P, Wang JN, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines[J]. J Cheminform, 2014, 6(1): 13. DOI: 10.1186/1758-2946-6-13.  

6.Xu HY, Zhang YQ, Liu ZM, et al. ETCM: an encyclopaedia of traditional Chinese medicine[J]. Nucleic Acids Res, 2019, 47(D1): D976-D982. DOI: 10.1093/nar/gky987.

7.Shao B, Guo HZ, Cui YJ, et al. Steroidal saponins from Smilax china and their anti-inflammatory activities[J]. Phytochemistry, 2007, 68(5): 623-630. DOI: 10.1016/j.phytochem.2006.10.026.

8.徐燕, 王海燕, 蒋家月, 等. 菝葜中的甾体皂苷及其细胞毒活性[J]. 中国实验方剂学杂志, 2011, 17(11): 92-96. [Xu Y, Wang HY, Jiang JY, et al. Studies on steroidal saponins from Smilax china and their cytotoxic activities[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2011, 17(11): 92-96.] DOI: 10.3969/j.issn.1005-9903.2011.11.029.

9.胡灯. 菝葜的甾体皂苷成分及其抗肿瘤活性研究[D]. 广州: 南方医科大学, 2017. DOI: 10.27003/d.cnki.gojyu. 2017.000154.

10.时向利, 朱倩. HPLC法同时测定不同产地菝葜中5种成分的含量[J]. 化工设计通讯, 2022, 48(11): 237-239. [Shi XL, Zhu Q. The contents of five components in different origin were determined simultaneously by HPLC[J]. Chemical Engineering Design Communications, 2022, 48(11): 237-239] DOI: 10.3969/j.issn.1003-6490. 2022.11.079.

11.徐梦. 菝葜多酚成分分析及其生物活性研究[D]. 南昌: 江西农业大学, 2020. DOI: 10.27177/d.cnki.gjxnu.2020.000423.

12.陈佳倩, 金晨, 徐博伦, 等. 菝葜总黄酮主成分鉴定及苯酚胶浆诱导大鼠盆腔炎的抗炎作用评价[J]. 中国药学(英文), 2021, 30(2): 157-168. [Chen JQ, Jin C, Xu BL, et al. Identification of major compounds of total flavonoids from Smilax china and evaluation of anti-inflammatory effect on phenol mucilage-induced pelvic inflammation in rats[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(2): 157-168.] DOI: 10.5246/jcps.2021.02.013.

13.冯锋, 柳文媛, 陈优生, 等. 菝葜中黄酮和芪类成分的研究[J]. 中国药科大学学报, 2003, (2): 23-25. [Feng F, Liu WY, Chen YS, et al. Flavonoids and stilbenes from Smilax china[J]. Journal of China Pharmaceutical University, 2003, (2): 23-25.] DOI: 10.3321/j.issn:1000- 5048.2003.02.005.

14.邵波,郭洪祝,果德安. 菝葜中黄酮和二苯乙烯类成分的研究[J]. 中草药, 2009, 40(11): 1700-1703. [Shao  B, Guo HZ, Guo DA. Flavonoids and stilbenes from Smilax china[J]. Chinese Traditional and Herbal Drugs, 2009, 40(11): 1700-1703]. DOI: 10.3321/j.issn:0253-2670. 2009.11.004.

15.Yang CH, Tang QF, Liu JH, et al. Preparative isolation and purification of phenolic acids from Smilax china by high-speed counter-current chromatography[J]. Sep Purif Technol, 2008, 61(3): 474-478. DOI: 10.1016/j.seppur.2008.02.017.

16.Zheng XW, Zhang L, Zhang WY, et al. Two new xanthones, a new lignin, and twenty phenolic compounds from Smilax china and their NO production inhibitory activities[J]. J Asian Nat Prod Res, 2020, 22(6): 509-520. DOI: 10.1080/10286020.2019.1598395.

17.干国平,于伟,刘焱文. 菝葜化学成分的研究[J]. 时珍国医国药, 2007, 18(6): 1404-1405. [Gan GP, Yu  W, Liu YW. Studies on chemical constituents of Smilax china L.[J]. Lishizhen Medicine and Materia Medica Research, 2007, 18(6): 1404-1405.] DOI: 10.3969/j.issn.1008-0805.2007.06.067.

18.Li YT, Feng X, Feng YJ, et al. Steroidal saponins from the rhizomes of Smilax china and their inhibitory effects on lipopolysaccharide-induced proinflammatory cytokines expression[J]. Planta Med, 2023, 89(2): 208-217. DOI: 10.1055/a-1896-1098.

19.Li X, Chu LL, Liu SS, et al. Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice[J]. Phytomedicine, 2022, 95: 153728. DOI: 10.1016/j.phymed.2021.153728.

20.Zhang Y, Pan XL, Ran SQ, et al. Purification, structural elucidation and anti-inflammatory activity in vitro of polysaccharides from Smilax china L.[J]. Int J Biol Macromol, 2019, 139: 233-243. DOI: 10.1016/j.ijbiomac. 2019.07.209.

21.Jiang SY, Wei Q, Ye XC, et al. The anti-inflammatory effect of Smilax china L. extract on LPS-stimulated THP-1 via downregulation of MAPK and NF-κB signaling pathway[J]. Evid Based Complement Alternat Med, 2021, 2021: 9958808. DOI: 10.1155/2021/9958808.

22.邓青芳, 周欣, 陈华国. 多糖抗肝损伤作用及其机制研究进展[J]. 中国中药杂志, 2016, 41(16): 2958-2967. [Deng QF, Zhou X, Chen HG. Advance in study on hepatoprotective effects and its mechanism of polysaccharides[J]. China Journal of Chinese Materia Medica, 2016, 41(16): 2958-2967.] DOI: 10.4268/cjcmm 20161603.

23.Wang KP, Yang LL, Zhou J, et al. Smilax china L. Polysaccharide alleviates oxidative stress and protects from acetaminophen-induced hepatotoxicity via activating the Nrf2-ARE pathway[J]. Front Pharmacol 2022, 13: 888560. DOI: 10.3389/fphar.2022.888560.

24.褚路路. 菝葜多糖的理化性质、护肝活性及菝葜淀粉复合凝胶体系的探究[D]. 南昌: 江西农业大学, 2019. DOI: 10.27177/d.cnki.gjxnu.2019.000328.

25.Boby N, Lee EB, Abbas MA, et al. Ethanol-induced hepatotoxicity and alcohol metabolism regulation by GABA-enriched fermented Smilax china root extract in rats[J]. Foods, 2021, 10(10): 2381. DOI: 10.3390/foods 10102381.

26.Ma Y, Pei TT, Song LY, et al. Flavonoids from Smilax china L. Rhizome improve chronic pelvic inflammatory disease by promoting macrophage reprogramming via the NLRP3 inflammasome-autophagy pathway[J]. J Funct Foods, 2023, 109: 105802. DOI: 10.1016/j.jff.2023.105802.

27.Pan XL, Wang HY, Zheng ZM, et al. Pectic polysaccharide from Smilax china L. ameliorated ulcerative colitis by inhibiting the galectin-3/NLRP3 inflammasome pathway[J]. Carbohydr Polym, 2022, 277: 118864. DOI: 10.1016/j.carbpol.2021.118864.

28.Xu M, Xue H, Qiao GX, et al. Regulating the imbalance of gut microbiota by Smilax china L. polyphenols to alleviate dextran sulfate sodium-induced inflammatory bowel diseases[J]. Am J Chin Med, 2022, 50(2): 553-568. DOI: 10.1142/S0192415X22500215.

29.邝玉慧, 徐方飚, 陈晓琦, 等. 基于计算机虚拟筛选研究菝葜抗肝癌的作用机制[J]. 中医学报, 2021, 36(8): 1751-1757. [Kuang YH, Xu FB, Chen XQ, et al. Study of anti-liver cancer mechanism of Baqia (Smilax china L.) based on computer virtual screening[J]. Acta Chinese Medicine, 2021, 36(8): 1751-1757.] DOI: 10.16368/j.issn.1674-8999.2021.08.365.

30.朱立华, 周融融, 黄生武, 等. 基于网络药理学探析复方菝葜治疗非小细胞肺癌的机制[J]. 中医药导报, 2023, 29(8): 132-139. [Zhu LH, Zhou RR, Huang SW, et al. Study on the mechanism of compound Baqia (Smilacis chinae rhizoma) in the treatment of non-small cell lung cancer based on network pharmacology[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2023, 29(8): 132-139.] DOI: 10.13862/j.cn43-1446/r.2023. 08.026.

31.于丽秀, 胡丽玲, 廖婧, 等. 菝葜不同提取部位对卵巢癌细胞的活性影响[J]. 中国药师, 2015, 18(3): 373-375. [Yu LX, Hu LL, Liao J, et al. Effect of different extracts of Smilax china L. on the activity of ovarian cancer cells[J]. China Pharmacist, 2015, 18(3): 373-375.] DOI: 10.3969/j.issn.1008-049X.2015.03.005.

32.Fu S, Yang YF, Liu D, et al. Flavonoids and tannins from Smilax china L. rhizome induce apoptosis via mitochondrial pathway and MDM2-p53 signaling in human lung adenocarcinoma cells[J]. Am J Chin Med, 2017, 45(2): 369-384. DOI: 10.1142/S0192415X17500239.

33.邱千, 邓爱萍, 戴琪, 等. 菝葜鞣质抗肺癌活性研究 [J]. 湖北中医药大学学报, 2017, 19(1): 43-47. [Qiu  Q, Deng  AP, Dai Q, et al. Study on anti-lung cancer activity of tannins from Smilax china L.[J]. Journal of Hubei University of Chinese Medicine, 2017, 19(1): 43-47.] DOI: 10.3969/j.issn.1008-987x.2017.01.12.

34.Chalertpet K, Sangkheereeput T, Somjit P, et al. Effect of Smilax spp. and Phellinus linteus combination on cytotoxicity and cell proliferation of breast cancer cells[J]. BMC Complement Med Ther, 2023, 23(1): 177. DOI: 10.1186/s12906-023-04003-x.

35.郭红, 黄艳丽, 邢辉, 等. 菝葜皂苷元调控circ-PRKCI/miR-130a-5p抑制卵巢癌细胞CAOV3增殖、迁移及侵袭[J]. 时珍国医国药, 2021, 32(12): 2875-2878. [Guo H, Huang YL, Xing H, et al. circ-PRKCI/miR-130a-5p regulates the proliferation, migration and invasion of CAOV3 ovarian cancer cells[J]. Lishizhen Medicine and Materia Medica Research, 2021, 32(12): 2875-2878.] DOI: 10.3969/j.issn.1008-0805.2021.12.14.

36.吴源陶, 邹译娴, 张春虎, 等. 菝葜皂苷元对结直肠癌细胞HT-29凋亡和自噬的影响[J]. 湖南中医药大学学报, 2021, 41(11): 1645-1649. [Wu YT, Zou YX, Zhang CH, et al. Effect of sarsasapogenin on apoptosis and autophagy of colorectal cancer lines HT-29[J]. Journal of Hunan University of Chinese Medicine, 2021, 41(11): 1645-1649.] DOI: 10.3969/j.issn.1674-070X.2021.11.001.

37.廖子君, 郑琪, 赵征,等. 菝葜皂苷对胃癌BGC-823细胞Bcl-2、Bax凋亡蛋白表达影响的实验研究[J]. 中国医药指南, 2018, 16(18): 1-2. [Liao ZJ, Zheng Q, Zhao  Z, et al. Study on the effect of sarsasapogenin to apoptosis of Bax and Bcl-2 protein expression of human gastric cancer lines BGC-823[J]. Guide of China Medicine, 2018, 16(18): 1-2.] DOI: CNKI:SUN:YYXK.0.2018-18-002.

38.Wang C, Zhou Q, Wu ST. Scopolin obtained from Smilax china L. against hepatocellular carcinoma by inhibiting glycolysis: a network pharmacology and experimental study[J]. J Ethnopharmacol, 2022, 296: 115469. DOI: 10.1016/j.jep.2022.115469.

39.Wu ST, Yuan Z, Piao XL, et al. The active components of Smilax china L. against cancer by interfering with the interactions among associated proteins[J]. J Funct Foods, 2023, 106: 105591. DOI: 10.1016/j.jff.2023.105591.

40.Silva ICA, Azevedo LS, Castro AHF, et al. Chemical profile, antioxidant potential and toxicity of Smilax brasiliensis Sprengel (Smilacaceae) stems[J]. Food Res Int, 2023, 168: 112781. DOI: 10.1016/j.foodres.2023.112781.

41.李俊芳, 蓝青, 李兰芳, 等. 粉背菝葜抗氧化作用预实验[J]. 广州化工, 2021, 49(24): 31-33, 36. [Li JF, Lan  Q, Li LF, et al. Preliminary experiments on antioxidation of Smilax hypoglauca[J]. Guangzhou Chemical Industry, 2021, 49(24): 31-33, 36.] DOI: 10.3969/j.issn.1001-9677. 2021.24.011.

42.Joo JH, Han MH, Kim JI, et al. Antimicrobial activity of Smilax china L. root extracts against the acne-causing bacterium, Cutibacterium acnes, and its active compounds[J]. Molecules, 2022, 27(23): 8331. DOI: 10.3390/molecules27238331.

43.Xu M, Xue H, Li X, et al. Chemical composition, antibacterial properties, and mechanism of Smilax china L. polyphenols[J]. Appl Microbiol Biotechnol, 2019, 103(21-22): 9013-9022. DOI: 10.1007/s00253-019-10100-0.

44.Li X, Yang LC, Li JG, et al. A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice[J]. Food Funct, 2021, 12(13): 5862-5875. DOI: 10.1039/d1fo00282a.

45.Zhang Y, Pan XL, Ran SQ, et al. Purification, structural elucidation and anti-inflammatory activity in vitro of polysaccharides from Smilax china L.[J]. Int J Biol Macromol, 2019, 139: 233-243. DOI: 10.1016/j.ijbiomac. 2019.07.209.

46.Kong L, Zhang WK, Liu SS, et al. Quercetin, engelitin and caffeic acid of Smilax china L. polyphenols, stimulate 3T3-L1 adipocytes to brown-like adipocytes via β3-AR/AMPK signaling pathway[J]. Plant Foods Hum Nutr, 2022, 77(4): 529-537. DOI: 10.1007/s11130-022-00996-x.

47.Yang LC, Zhao Y, Pan YF, et al. Dietary supplement of Smilax china L. ethanol extract alleviates the lipid accumulation by activating AMPK pathways in high-fat diet fed mice[J]. Nutr Metab (Lond), 2019, 16: 6. DOI: 10.1186/s12986-019-0333-z.

48.郑国栋, 朱晓娟, 张清峰, 等. 菝葜对小鼠肝脏脂肪代谢的影响[J]. 中国食品学报, 2016, 16(3): 30-35. [Zheng  GD, Zhu XJ, Zhang QF, et al. Effects of Smilax china L. on hepatic fat metabolism in mice[J]. Journal of Chinese Institute of Food Science and Technology, 2016, 16(3): 30-35.] DOI: 10.16429/j.1009-7848.2016.03.004.

49.赵磊. 土茯苓总黄酮与肠道菌群相互作用的研究 [D]. 江苏苏州: 苏州大学, 2020. DOI: 10.27351/d.cnki.gszhu. 2020.003959.

50.Chen LY, Yin HF, Lan Z, et al. Anti-hyperuricemic and nephroprotective effects of Smilax china L.[J]. J Ethnopharmacol, 2011, 135(2): 399-405. DOI: 10.1016/j.jep.2011.03.033.

51.Li X, Liu SS, Jin WL, et al. Identification of the constituents of ethyl acetate fraction from Smilax china L. and determination of xanthine oxidase inhibitory properties[J]. Int J Mol Sci, 2023, 24(6): 5158. DOI: 10.3390/ijms24065158.

52.Zhao BT, Le DD, Nguyen PH, et al. PTP1B, α-glucosidase, and DPP-IV inhibitory effects for chromene derivatives from the leaves of Smilax china L.[J] Chem Biol Interact, 2016, 253: 27-37. DOI: 10.1016/j.cbi.2016.04.012.

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