Objective  To analyze of the therapeutic effect of Weifuchun capsules combined with quadruple therapy on elderly patients with chronic atrophic gastritis (CAG) infected with Helicobacter pylori (Hp).

Methods  Elderly Hp-infected CAG patients admitted to Affiliated Hospital of Shaoxing University from April 2019 to April 2023 were divided into a control group (treated with classic quadruple therapy) and an experimental group (treated with Weifuchun capsules combined with classic quadruple therapy) according to different regimens. The clinical treatment effects of two groups of patients were compared, the clinical symptom scores, changes in serum gastrointestinal hormones, inflammatory factors levels before and after treatment, and the adverse reactions and Hp recurrence were compared.

Results  A totol of 300 patients were included in the study, with 150 cases in each group. After treatment, the clinical symptom score, pepsinogen (PG) II, high-sensitivity C-reactive protein (hs-CRP), serum tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-8 levels in the experimental group were lower than those in the control group (P<0.05), and the levels of PG I, gastrin-17 (GAS-17) in the serum, and total effective rate were higher than those in the control group (P<0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05), and no Hp recurrence was seen in either group.

Conclusion  The combination of Weifuchun capsules and classic quadruple therapy has shown good efficacy in treating elderly Hp-infected CAG patients, which can effectively improve the clinical symptoms, regulate gastrointestinal hormone secretion, and has good safety.

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