Objective  To conduct the bibliometric and visual analysis of relevant literature on the hierarchical research of Qinglongyi medicine using CiteSpace 6.1.R6, summarize the current research status and trends of traditional Chinese medicine (TCM) Qinglongyi, and provide valuable references for future researchers.

Methods  Databases including CNKI, WanFang Data, and VIP were used as retrieval platforms, the search period is 2004-2024. Literature was selected using NoteExpress literature management software, and CiteSpace 6.1.R6 software was employed for visual analysis of publication volume, authors, institutions, and keywords.

Results  A total of 285 related articles were included. The results showed that the number of publications on the medical level of Qinglongyi from 2004 to 2024 showed a slow increase, but the research enthusiasm in this field was relatively insufficient, with an average of 14 papers published per year. The author collaboration network revealed that there were communications and cooperations among authors, but not close enough. The institutional collaboration network displayed two major research clusters led by Heilongjiang University of Chinese Medicine and Harbin University of Commerce, showing regional concentration with limited inter-provincial exchange. Keyword analysis indicated research primarily focused on the chemical composition and pharmacological effects of Qinglongyi, with chemical components including naphthoquinones, terpenes, flavonoids, and phenolic acids. Qinglongyi exhibits antioxidant, anticancer, antimicrobial, and anti-inflammatory effects, with anticancer research being particularly prominent.

Conclusion  Despite the progress made in the TCM research of Qinglongyi domestically, there are still unresolved issues. These gaps mainly involve insufficient exploration of the mechanisms of action of Qinglongyi, limited clinical validation, and inadequate cross-regional and interdisciplinary collaborations. It suggests that follow-up research should deepen the research on the therapeutic mechanism of Qinglongyi, promote rigorously designed clinical trials, and promote close cooperation across regions and disciplines.

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