Chemical constituents of the stems of Acanthopanax leucorrhizus

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Author: XIAO Shan ^1, ² LUO Jiao ² DAI Ling ³  LIU Xiangqian ²

Affiliation: 1. Department of Pharmacy, Affiliated Nanhua Hospital, University of South China, Hengyang 421001, Hunan Province, China 2. School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China 3. School of Pharmacy, Hunan Vocational College of Science and Technology, Changsha 410200, China

Keywords: Acanthopanax leucorrhizus Stems Chemical constituents Separation and purification Structural identification

DOI: 10.12173/j.issn.2097-4922.202505047

Reference: XIAO Shan, LUO Jiao, DAI Ling, LIU Xiangqian. Chemical constituents of the stems of Acanthopanax leucorrhizus[J]. Yaoxue QianYan Zazhi, 2025, 29(10): 1669-1678. DOI: 10.12173/j.issn.2097-4922.202505047.[Article in Chinese]  Copied

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Abstract

Objective To study the chemical constituents in the dried stems of Acanthopanax leucorrhizus.

Methods The compounds were isolated and purified by normal/reverse phase silica gel column chromatography, polyamide column chromatography, preparative liquid chromatography, and recrystallization. The structural identification was achieved by correlating physicochemical properties with spectroscopic data.

Results A total of 19 compounds were isolated and purified from the methanol extract of the stem of Acanthopanax leucorrhizus, including trans-p-menthane-1α,2β,8-triol (1), kaurenoic acid (2), β-sitosterol palmitate (3), daucosterol (4), myristic acid (5), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one (6), erythro-7-methoxysyr- ingylglycerol (7), (7S,8R)-syringoylglycerol (8), threo-5-hydroxy-3,7-dimethoxyphenyl-propane-8,9-diol (9), protocatechuic acid methyl ester (10), threo-2,3-bis-(4-hydroxy-3-methoxy-phenyl)-3-methoxy-propanol (11), eythro-2,3-bis-(4-hydroxy-3-methoxyphenyl)-3-methoxypropanol (12), isolariciresinol (13), lariciresinol(14), (-)-(2R,3R)-secoisolariciresinol (15), threo-7-methoxysyringylglycerol (16), C-veratroylglycol (17), 5’-methoxylariciresinol (18), and mesosecoisolariciresinol (19).

Conclusion Compounds 1, 3, 5-6, 8-9, 12-13, 15-17, and 19 were isolated from Araliaceae for the first time. Compounds 1, 3, 5-9, 11-13, 15-19 were isolated from plants of Acanthopanax Miq. for the first time. All compounds were isolated from this species for the first time.

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