Objective  To prepare curcumin-loaded (CUR) mesoporous silica nanoparticles (MSN) modified by polydopamine (PDA), and study their pharmaceutical properties, drug release in vitro and antitumor activity in vitro.

Methods  Mesoporous silica nanoparticles were synthesized by template method and modified with PDA. The pharmaceutical properties of the nanoparticles were investigated. The responsive release of drug-loaded preparations at different pH was studied. The biocompatibility of the carrier and the inhibition rate of cell growth in vitro of the drug-loaded preparations were evaluated. The uptake of the drug-loaded preparations by tumor cells was examined.

Results  The particle size of MSN was uniform. After the PDA modification, the drug release rate of CUR@MSN-PDA was significantly dependent on pH. The results of biocompatibility experiments showed that, the cell survival rate was above 85% after co-cultured with MDA-MB-231 cells for 24 h. The results of in vitro tumor cell growth inhibition test showed that, the growth inhibition rate of CUR@MSN-PDA on tumor cells was significantly higher than that of CUR@MSN. The results of cell uptake showed that the fluorescent strength of CUR@MSN-PDA in the cell was significantly stronger than that of the CUR@MSN.

Conclusion  The nano-carrier constructed has significant pH response and enhanced anti-tumor activity, which can provide a theoretical basis for the drug delivery of CUR.

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