Objective  To explore the research hotspots and development trends of pyrroloquinoline quinone (PQQ), and explore the research and application value of PQQ.

Methods  In this study, Web of Science was used as the retrieval database to search for literature related to PQQ published from 1985 to 2022, and VOSviewer soſtware was used to include the keywords, countries and regions, journals, etc. Bibliometric analysis was performed on these literatures.

Results  A total of 1 512 articles were included, with an overall upward trend in the number of annual publications. The journal category with the highest number of publications was Biochemistry and Molecular Biology. Journal of Biological Chemistry had the highest total link strength. The high-frequency keywords mainly included dietary nutrition supplement, mitochondria, antioxidant, etc. The visualization results of countries and regions showed that although China  started its research relatively late, and it had a strong connection intensity with other countries.

Conclusion  In recent years, the research heat of PQQ has gradually increased, and its antioxidant effects, improvement of mitochondrial function and action targets may be the hotpots of future research. PQQ still has broad development prospects, and will inject new vitality into the pharmaceutical and healthcare industry.

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