Objective  To explore the clinical efficacy of Jinfeng pill (JFP) combined with estradiol valerate tablets (EVT) in the treatment of moderate to severe patients with intrauterine adhesion (IUA) after surgery.

Methods  The data of IUA patients admitted to the department of gynecology of Yiwu Central Hospital from January 2022 to June 2024 were retrospectively included. According to the postoperative treatment plans of IUA, the patients were divided into the EVT group and the EVT+JFP group. The main observation indicators included the rate of IUA recurrence and the menstrual improvement in the treatment of three menstrual cycles. Secondary observations were the changes in endometrial parameters (endometrial thickness, endometrial pulsatility index, and endometrial resistance index), sex hormones [follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2)], and inflammatory indicators [vascular endothelial growth factor (VEGF), interleukin-18 (IL-18), and tumor necrosis factor-α (TNF-α)].

Results  A total of 139 IUA patients were included in the study, with 61 in the EVT group and 78 in the EVT+JFP group. After 3 menstrual cycles of treatment, the readhesion rate in the EVT+JFP group was significantly lower than that in the EVT group (P<0.05), and the treatment effectiveness rate was significantly higher than that in the EVT group (P<0.05). The endometrial thickness in the EVT+JFP group was significantly higher than that in the EVT group (P<0.05), while the endometrial pulsatility index and endometrial resistance index were significantly lower than those in the EVT group (P<0.05). The levels of FSH, LH, and E2 in patients after IUA sugery in the EVT+JFP group were significantly higher than those in the EVT group (P<0.05), while the levels of VEGF, IL-18, and TNF-α were significantly lower than those in the EVT group (P<0.05).

Conclusion  JFP combined with EVT could improve menstrual conditions, sex hormone, and inflammatory indicator levels, increase endometrial thickness, and prevent the occurrence of readhesion in patients after IUA surgery.

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