Platelet-derived exosomes (PEVs) are a subpopulation of nanoscale extracellular vesicles released by platelets. Studies have shown that PEVs play an important regulatory role in a variety of physiological and pathological processes, such as inflammatory response, angiogenesis, and cancer progression. Thanks to its nanoscale size characteristics, PEVs have a significant high permeability and long retention effect, can effectively penetrate the vascular barrier and specifically aggregate at the target site of the disease, which makes it a highly potential drug targeted delivery carrier. However, the current safety evaluation system of PEVs has not been perfected, and its production process and quality control standards are still difficult to meet drug regulatory requirements. How to ensure the quality uniformity and stability of PEVs during large-scale production is the focus of the next step of research and development. This article systematically reviews the biological functions of PEVs, drug loading preparation methods, and the latest research progress in the field of targeted drug delivery, in order to provide a theoretical basis and practical reference for the development of new nano drug carriers.

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