Objective  To investigate the clinical effect of the combination of somatostatin and multidisciplinary collaborative on-demand intervention on patients with acute pancreatitis (AP).

Methods  AP patients admitted to department of gastroenterology of Hangzhou First People’  s Hospital were selected from January 2020 to January 2025, and were categorized into the control group (somatostatin combined with routine intervention) and the observation group (somatostatin combined with multidisciplinary collaborative on-demand intervention). The clinical efficacy, pancreatic injury markers [serum amylase (AMY), lipase (LPS)], inflammation-related indicators [interleukin-18 (IL^-18), interleukin-6 (IL-6), C-reactive protein (CRP)], organ function indicators [blood urea nitrogen (BUN), creatinine (Cr), total bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood lactic acid (Lac)], AP-related complications and adverse drug reactions were compared between both groups.

Results  A total of 120 AP patients were included, with 60 patients in each group. After treatment, the total clinical effective rate in the observation group was higher compared to the control group (93.33% vs. 80.00%, P<0.05). The levels of AMY, LPS, IL^-18, IL-6, CRP, BUN, Cr, total bilirubin, ALT, AST and Lac in the two groups were decreased compared with those before treatment (P<0.05), and the observation group had lower levels (P<0.05). The incidence rates of AP-related complications and adverse drug reactions exhibited no significant differences between the two groups (P>0.05).

Conclusion  Somatostatin combined with multidisciplinary collaborative on-demand intervention has significant clinical efficacy in the treatment of AP. Additionally, it can relieve the pancreatic injury and inflammatory response, and improve the organ function.

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