Polydeoxyribonucleotide (PDRN), a linear polyribonucleotide fragment with low molecular weigh, is known for its bioactivity and effective tissue healing, primarily extracted from fish germ cells. Reports and clinical findings have shown that PDRN has low immunogenicity and low toxicity, which shows potential application in tissue repair, such as skin wound , corneas, digestive tract , and bone injury repair. The article mainly focus on the application of PDRN in tissue injury and repair, and comprehensively discuss the role and  mechanism of PDRN in tissue repair which provide theoretical support for the research and development of tissue repair materials.

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