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Home Articles Vol 27,2024 No.5 Detail

Comparative study of dry and wet extrusion granulation of Five-Juice Decoction granules

Published on May. 31, 2024Total Views: 1172 times Total Downloads: 347 times Download Mobile

Author: WANG Siyi 1, 2 XIE Yani 1, 2 CHEN Guangyu 1, 2, 3

Affiliation: 1. Engineering Technology Research Center For Medicinal and Functional Food, Hunan University of Chinese Medicine, Changsha 410208, China 2. Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine, Changsha 410208, China 3. Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha 410208, China

Keywords: Five-Juice Decoction Granules Dry granulation Wet extrusion granulation Granule yield Box-Behnken design-response

DOI: 10.12173/j.issn.1008-049X.202312149

Reference: WANG Siyi, XIE Yani, CHEN Guangyu.Comparative study of dry and wet extrusion granulation of Five-Juice Decoction granules[J].Zhongguo Yaoshi Zazhi,2024, 27(5):756-761.DOI: 10.12173/j.issn.1008-049X.202312149.[Article in Chinese]

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Abstract

Objective  To optimize the dry granulation technology of Five-Juice Decoction granules.

Methods  The granule yield was used as the evaluation index to optimize the dry granulation process parameters of Five-Juice Decoction granules by Box-Behnken design-response surface design test. The granule yield, repose angle, dissolve time, humidity absorption rate and particle roundness were used as evaluation indexes, and three batches of validation tests were conducted to compare the difference between the dry granules optimized in this study and the wet extruded granules optimized in previous studies.  

Results  The optimal technological parameters for dry granulation of Five-Juice Decoction granules were as follows: the pressure of the hydraulic system was 3.5 Mpa, the wheel speed was 5.4 r/min, the feeding speed was 7.2 r/min, and the granulation speed was 80 r/min. The technological parameters of wet granulation were as follows: the soft material was made from 90% ethanol, extruded through a 10-mesh sieve for granulation, and dried under reduced pressure at 50 °C to a moisture content of <5%. The granule yield and humidity absorption rate of dry granulation were better than those of wet extruded granules.

Conclusion  Dry granulation process is better than wet extrusion process of Five-Juice Decoction granules. The optimized dry granulation process is stable and feasible, which can provide a reference for industrial production.

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References

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