Objective  To explore the clinical efficacy of escitalopram combined with multidisciplinary collaborative management model (MCMM) on adolescents with first-episode major depressive disorder (MDD).

Methods  Two hundred adolescents with first-episode MDD who admitted to Fuyang Third People's Hospital, Anhui Province, from January 2019 to November 2023, were selected as study participnts. They were randomly divided into a control group and a MCMM group. Both groups of patients received sertraline hydrochloride tablets and routine psychiatric care for 8 weeks. Additionally, the MCMM group received an MCMM intervention on this basis. The clinical efficacy of the interventions, pre- and post-treatment assessments included clinical scale data [Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Connor-Davidson Resilience Scale (CD-RISC)], inflammatory factors [interleukin-1β (IL^-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)], neurotrophin factors [serotonin (5-hydroxytryptamine, 5-HT) and glial cell-derived neurotrophic factor (GDNF)] were compared between the two groups.

Results  Before the intervention, there were no statistical differences in the clinical scale data, inflammatory factors and neurotrophic factors between the two groups (P>0.05). After 8 weeks of intervention, the HAMD score, HAMA score, serum IL-1β, IL-6, TNF-α, 5-HT, and GDNF levels significantly decreased compared with pre-intervention (P<0.05), while the CD-RISC score significantly increased (P<0.05). In addition, the MCMM group showed greater reductions in HAMD, HAMA, IL-1β, IL-6, TNF-α, 5-HT, and GDNF levels and a greater increase in CD-RISC score compared to the control group (P<0.05).

Conclusion  Compared with sertraline combined with routine care, MCMM significantly alleviates anxiety and depression, enhances psychological resilience, and reduces inflammation in MDD patients.

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