Ziziphi spinosae semen mainly contains contents of saponins, flavonoids, alkaloids and aliphatic acids. Meanwhile, it has a variety of activities such as sedative-hypnotic, anti-anxiety, anti-depression, nerve protection, cardiovascular and cerebrovascular protection, liver protection, and antioxidant, which is widely used in medicine, food, health food and other fields. The chemical constituents, pharmacological action and clinical application of Ziziphi spinosae semen were systematically summarized in this paper by reviewing the literature, in order to provide theoretical guidance for the sustainable development of the resources and the rational use of Ziziphi spinosae semen.

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