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Development and application of "quality evaluation through character identification" theory in traditional Chinese medicine

Published on Oct. 15, 2024Total Views: 217 times Total Downloads: 38 times Download Mobile

Author: XIAO Yujie 1 ZHAO Xiangsheng 1 WEI Jianhe 2

Affiliation: 1. Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Haikou 570311, China 2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China

Keywords: Quality evaluation through character identification Appearance character Quality evaluation Correlation analysis Electronic sense technology Development history Application significance

DOI: 10.12173/j.issn.2097-4922.202405063

Reference: XIAO Yujie, ZHAO Xiangsheng, WEI Jianhe.Development and application of "quality evaluation through character identification" theory in traditional Chinese medicine[J].Yaoxue QianYan Zazhi,2024, 28(1):155-169.DOI: 10.12173/j.issn.2097-4922.202405063.[Article in Chinese]

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Abstract

"Quality evaluation through identification" (QECI) is a theory that summarizes the essence of quality identification experience about traditional Chinese medicine (TCM). As an important component of the current quality evaluation system of TCM, the theory provides theoretical guidance for controlling and evaluating TCM’s quality. Identifying based on human senses, traditional appearance identification relies on experience, which is subjective, difficult to quantify, and poorly repeatable. Modern measurement tools and biomimetic technology can quantify appearance characters (shape, color, smell, taste) of TCM. Then associate the results with content of active ingredients or biological effects. Make use of the visualization, quantifiability, portability, and repeatability of modern scientific means and screen feasible and controllable quality control indicators, which can be applied to quality evaluation and control of TCM’s production and processing in each stage. The origin, connotation, modern research progress, and application value of QECI are reviewed, aiming to provide reference for addressing the shortcomings of traditional appearance evaluation, expanding the application scope of QECI, and promoting the construction of TCM’s quality evaluation system.

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References

1. 笪舫芳, 戴忠华, 朱华. 中药品质评价研究现状及发展趋势[J]. 中华中医药学刊, 2017, 35(6): 1485-1488. [Da FF, Dai ZH, Zhu H. Progress and development trend of traditional Chinese medicine quality evaluation[J]. Chinese Archives of Traditional Chinese Medicine, 2017, 35(6): 1485-1488.] DOI: 10.13193/j.issn.1673-7717.2017. 06.036.

2. 钱锦秀. 基于传统鉴别经验的中药材现代品质评价研究[D]. 北京:中国中医科学院, 2023. DOI: 10.27658/d.cnki.gzzyy.2023.000183.

3. 谢宗万. 中药品种传统经验鉴别“辨状论质”论[J]. 时珍国药研究, 1994, (3): 19-21. https://d.wanfangdata.com.cn/periodical/szgygy199403016.

4. 唐廷猷. 清人黄奭辑《范子计然》西汉的药材商品手册[J]. 中国现代中药, 2018, 20(8): 1028-1033. DOI: 10.13313/j.issn.1673-4890.20180524001.

5. 周祯祥, 张廷模, 闵志强, 等. 论《神农本草经》对中药学的贡献[J]. 中药与临床, 2020, 11(3): 43-49. [Zhou ZX, Zhang TM, Min ZQ, et al. The contribution of Shen Nong Ben Cao Jing to traditional Chinese medicine[J]. Pharmacy and Clinics of Chinese Materia Medica, 2020, 11(3): 43-49.] DOI: CNKI:SUN:LCZY.0.2020-03-013.

6. 张铁军, 刘昌孝. 中药五味药性理论辨识及其化学生物学实质表征路径[J]. 中草药, 2015, 46(1): 1-6. [Zhang TJ, Liu CX. Identification of Chinese materia medica and its chemical biology characterization path on five taste theory[J]. Chinese Traditional and Herbal Drugs, 2015, 46(1): 1-6.] DOI: 10.7501/j.issn.0253-2670.2015.01.001.

7. 罗琼, 柳长华, 成莉, 等. 《神农本草经》在我国药物规范历史中的地位探讨[J]. 北京中医药, 2015, 34(1): 29-31. DOI: 10.16025/j.1674-1307.2015.01.009.

8. 金久宁. 唐宋时期的中药资源调查与官修本草 [J]. 中国现代中药, 2014, 16(11): 937-941. [Jin JN. Investigation of Chinese medicine resources during Tang and Song dynasties and official-compilation herbal classics[J]. Modern Chinese Medicine, 2014, 16(11): 937-941.] DOI: 10.13313/j.issn.1673-4890.2014.11.015.

9. 林玉歆, 张大金, 李惠民. 论《本草图经》的贡献[J]. 长春中医药大学学报, 1991, (3): 22-24. DOI: 10.13463/j.cnki.cczyy.1991.03.017.

10. 彭华胜, 王德群, 郝近大, 等. 宋代《本草图经》的药材质量优劣评价观[A]. 第十八届全国药学史暨本草学术研讨会学术论文集[C]. 北京:中国药学会药学史专业委员会, 2015: 6.

11. 李昂, 陈悦. 中文古籍中植物图像表达特点刍议[J]. 自然科学史研究, 2015, 34(2): 164-181. [Li A, Chen Y. A preliminary study on the expression characteristics of plant illustrations in ancient Chinese books[J]. Studies in the History of Natural Sciences, 2015, 34(2): 164-181.] DOI: 10.3969/j.issn.1000-0224.2015.02.003.

12. 刘川玉, 唐建红. 《本草纲目》对部分中药材真伪优劣的鉴定[J]. 中国民族民间医药, 2010, 19(14): 57. DOI: 10.3969/j.issn.1007-8517.2010.14.053.

13. 马栋, 李小琴, 薛幸嫔, 等. 关于中药黄芩“辨状论质”的本草考证研究[J]. 中药材, 2022, 45(10): 2516-2521.DOI: 10.13863/j.issn1001-4454.2022.10.043.

14. 刘伟, 周冰谦, 王晓, 等. 丹参药材粉末色泽与有效成分含量的相关性[J]. 中华中医药杂志, 2019, 34(4): 1466-1470. [Liu W, Zhou BQ, Wang X, et al. Correlational between the powder of color traits and active ingredient content in Salvia miltiorrhiza Bge[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2019, 34(4): 1466-1470.] https://mall.cnki.net/magazine/Article/BXYY201904038.htm.

15. 秦雪梅, 孔增科, 张丽增, 等. 中药材“辨状论质”解读及商品规格标准研究思路[J]. 中草药, 2012, 43(11): 2093-2098. [Qin XM, Kong ZK, Zhang LZ, et al. Interpretation of "assessing quality by distinguishing TCMM features" and research ideas about commodity specifications[J]. Chinese Traditional and Herbal Drugs, 2012, 43(11): 2093-2098.] DOI: CNKI:SUN:ZCYO.0.2012-11-003.

16. 陈依婷, 王冰, 孙艳涛, 等. 基于牡丹皮微观性状与抗炎活性相关的“辨状论质”研究[J]. 中医药信息, 2022, 39(10): 39-43. [Chen YT, Wang B, Sun YT, et al. Study of "Quality Discrimination by Character" on relationship between microproperties of Moutan Cortex and its anti-inflammatory activity[J]. Information on Traditional Chinese Medicine, 2022, 39(10): 39-43.] DOI: 10.19656/j.cnki.1002-2406.20221007.

17. 曹光昭, 林相龙, 俞越童, 等. 甘草止咳药效与其数字化颜色测量值的相关性分析[J]. 世界科学技术-中医药现代化, 2018, 20(7): 1245-1250. [Cao GZ, Lin XL, Yu YT, et al. Corelation analysis of the efficacy of licorice relieving cough and its digital color measurement value[J]. World Science and Technology-Modernization of Traditional Chinese Medicine, 2018, 20(7): 1245-1250.] DOI: 10.11842/wst.2018.07.027.

18. 王皓南, 田滢琦, 刘大会, 等. 中药“辨状论质”的历史、发展与应用[J]. 中药材, 2021, 44(3): 513-519. [Wang HN, Tian YQ, Liu DH, et al. History, development and application of the traditional Chinese medicine "Quality Evaluation Through Morphological Identification"[J]. Journal of Chinese Medicinal Materials, 2021, 44(3): 513-519.] DOI: 10.13863/j.issn1001-4454.2021.03.001.

19. 彭华胜, 张贺廷, 彭代银, 等. 黄芪道地药材辨状论质观的演变及其特点[J]. 中国中药杂志, 2017, 42(9): 1646-1651. [Peng HS, Zhang HT, Peng DY, et al. Evolution and characteristics of system,assessing quality by distinguishing features of traditional Chinese medicinal materials, of Dao-di herbs of Astragali Radix[J]. China Journal of Chinese Materia Medica, 2017, 42(9): 1646-1651.] DOI: 10.19540/j.cnki.cjcmm.2017.0066.

20. 齐大明, 刘天亮, 杨林林, 等. 不同茬次金银花的性状与成分变化及其相关性[J]. 中成药, 2022, 44(3): 849-855. [Qi DM, Liu TL, Yang LL, et al. Variations in morphological characters and constituents and their correlations of Lonicerae japonica Flos at different yearly blooming time[J]. Chinese Traditional Patent Medicine, 2022, 44(3): 849-855.] DOI: 10.3969/j.issn.1001-1528. 2022.03.030.

21. 杨丽, 冯冲, 蔡苗苗, 等. 基于“辨状论质”的巴戟天药材质量等级评价研究[J]. 中药材, 2020, 43(3): 640-646. DOI: 10.13863/j.issn1001-4454.2020.03.024.

22. 胡慧芳, 席少阳, 曹后康, 等. 基于辨状论质的蛇床子商品等级质量评价[J]. 中国中药杂志, 2023, 48(4): 900-907. [Hu HF, Xi SY, Cao HK, et al. Quality evaluation of Cnidii fructus in commodity grade based on theory of "quality evaluation through morphological identification"[J]. China Journal of Chinese Materia Medica, 2023, 48(4): 900-907.] DOI: 10.19540/j.cnki.cjcmm.20221102.102.

23. 王文雪, 都晓伟, 侯冰妍, 等. 基于“辨状论质”理论对南柴胡外观性状与内在质量的相关性研究[J]. 中国中药杂志, 2023, 48(7): 1815-1823. [Wang WX, Du XW, Hou BY, et al. Correlations between appearance traits and internal quality of Bupleurum scorzonerifolium Willd. roots based on theory of "quality evaluation through morphological identification"[J]. China Journal of Chinese Materia Medica, 2023, 48(7): 1815-1823.] DOI: 10.19540/j.cnki.cjcmm.20230115.102.

24. 刘天睿, 金艳, 孟虎彪, 等. 论中药“辨状论质”之辨色泽与品质评价的生物学内涵研究[J]. 中国中药杂志, 2020, 45(19): 4545-4554. [Liu TR, Jin Y, Meng HB, et al. Biological research of color and quality evaluation in "quality discrimination  by character" of Chinese medi[J]. Chinese Materia Medica, 2020, 45(19): 4545-4554.] DOI: 10.19540/j.cnki.cjcmm.20200726.102.

25. 曹萱, 张雨恬, 伍振峰, 等. 基于“辨状论质”理论对中药炮制火候的科学内涵研究[J]. 中国中药杂志, 2024, 49(5): 1196-1205. [Cao X, Zhang YT, Wu  ZF, et al. Research on the scientific connotation of TCM processing heat based on the theory of "distinguishing form and quality"[J]. China Journal of Chinese Materia Medica, 2024, 49(5): 1196-1205.] DOI: 10.19540/j.cnki.cjcmm. 20231120.302.

26. 蒲昕颖, 陈晓娇, 徐雅静, 等. 基于“辨色论质”的红大戟色泽与蒽醌类成分的相关性研究[J]. 时珍国医国药, 2023, 34(9): 2288-2290. DOI: 10.3969/j.issn.1008-0805.2023.09.70.

27. Ma R, Luo J, Qiao M, et al. Chemical composition of extracts from Dalbergia odorifera heartwood and its correlation with color[J]. Ind Crop Prod, 2022, 180: 114728. DOI: 10.1016/j.indcrop.2022.114728.

28. 张晓, 吴宏伟, 于现阔, 等. 基于电子眼技术的穿心莲质量评价[J]. 中国实验方剂学杂志, 2019, 25(1): 189-195. [Zhang X, Wu HW, Yu XK, et al. Quality evaluation of andrographis herba based on electronic-eye technique[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2019, 25(1): 189-195.] DOI: 10.13422/j.cnki.syfjx.20181702.

29. 唐进程, 祁晓娟, 赵江怡, 等. 基于“辨状论质”理论对唐古特大黄外观性状与内在质量的相关性研究 [J]. 中国现代中药, 2023, 25(9): 1887-1894. [Tang JC, Qi XJ, Zhao JY, et al. Correlation between appearance traits and internal quality of Rheum tanguticum Maxim. ex Balf. based on theory of "Quality Evaluation Through Morphological Identification"[J]. Modern Chinese Medicine, 2023, 25(9): 1887-1894.] DOI: 10.13313/j.issn. 1673-4890.20230406001.

30. 邓怡芳, 程钰洁, 钟志奎, 等. 金樱子蜜制前后UPLC指纹图谱与外观颜色的相关性研究[J]. 中药材, 2023, 46(10): 2443-2450. [Deng YF, Cheng YJ, Zhong ZK, et al. Study on the correlation between UPLC fingerprint and appearance color of Rosae laevigatae fructus before and after honey processing[J]. Journal of Chinese Medicinal Materials, 2023, 46(10): 2443-2450.] DOI: 10.13863/j.issn1001-4454.2023.10.012.

31. 刘振东, 兰金旭, 陈随清. HPLC结合电子眼技术分析不同采收期的枸橘药材质量[J]. 中国中药杂志, 2021, 46(20): 5253-5259. [Liu ZD, Lan JX, Chen SQ. Quality analysis of Citri Trifoliatae Fructus in different harvest time by HPLC combined with electronic eye technology[J]. China Journal of Chinese Materia Medica, 2021, 46(20): 5253-5259.] DOI: 10.19540/j.cnki.cjcmm.20210720.102.

32. 薛淑娟, 车奇涛, 陈随清. 基于“成分-颜色”关联分析地黄药材的质量及体外活性评价[J]. 时珍国医国药, 2023, 34(11): 2791-2796. [Xue SJ, Che QT, Chen SQ. Analysis of quality and activity evaluation in vitro of Radix Rehmanniae based on compo-nent color correlation[J]. Lishizhen Medicine and Materia Medica Research, 2023, 34(11): 2791-2796.] DOI: 10.3969/j.issn.1008-0805. 2023.11.61.

33. 于梦婷, 童黄锦, 毛春芹, 等. 基于色泽量化与主要成分含量的不同基原莪术饮片质量识别研究[J]. 中国中药杂志, 2021, 46(6): 1393-1400. [Yu MT, Tong HJ, Mao CQ, et al. Study on quality identification of Curcumae Rhizoma from different origins based on quantitative analysis of appearance color and content of main components[J]. China Journal of Chinese Materia Medica, 2021, 46(6): 1393-1400.] DOI: 10.19540/j.cnki.cjcmm. 20201111.301.

34. 王钧楠, 周永峰, 崔园园, 等. 基于抗炎生物效价的甘草传统感官评价科学性研究[J]. 中国现代中药, 2022, 24(6): 1018-1025. [Wang JN, Zhou YF, Cui YY, et al. Scientificity of traditional sensory evaluation of licorice based on anti-inflammatory potency[J]. Modern Chinese Medicine, 2022, 24(6): 1018-1025.] DOI: 10.13313/j.issn. 1673-4890.20211201002.

35. 张三妹, 吴梅, 吴飞, 等. 中药气味的化学成分检测及物质基础研究进展[J]. 天然产物研究与开发, 2023, 35(2): 332-341. [Zhang SM, Wu M, Wu F, et al. Research progress on chemical composition detection and substance basis of odor of traditional Chinese medicine[J]. Nat Prod Res Dev, 2023, 35(2): 332-341.] DOI: 10.16333/j.1001-6880.2023.2.017.

36. 王雅琪, 杨园珍, 伍振峰, 等. 中药挥发油传统功效与现代研究进展[J]. 中草药, 2018, 49(2): 455-461. [Wang YQ, Yang YZ, Wu ZF, et al. Traditional function and modern research progress on volatile oil in Chinese materia medica[J]. Chinese Traditional and Herbal Drugs, 2018, 49(2): 455-461.] DOI: 10.7501/j.issn.0253-2670. 2018.02.029.

37. Huang T, Sun Y, Guo Y, et al. Application of HS-SPME-GC-MS combined with electronic nose technology in the odor recognition of pseudostellariae radix[J]. Nat Prod Res, 2023, 37(14): 2457-2460. DOI: 10.1080/14786419.2022. 2045488.

38. 谭鹏, 朱薇, 包晓明, 等. 基于HS-SPME/GC-QQQ-MS/MS的冬虫夏草“腥气”辨识方法建立与应用 [J]. 中国实验方剂学杂志, 2021, 27(7): 100-111. [Tan P, Zhu W, Bao XM, et al. Establishment and application of identification method for fishy odor of cordyceps based on HS-SPME/GC-QQQ-MS/MS[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2021, 27(7): 100-111.] DOI: 10.13422/j.cnki.syfjx.20202149.

39. 魏丽红, 常福瑞, 闫爽, 等. 防风气味与化学成分相关性研究[J]. 中成药, 2024, 46(1): 324-329. DOI: 10.3969/j.issn.1001-1528.2024.01.056.

40. 刘阿静, 王娟, 王新潮, 等. 基于电子鼻技术对当归整体气味与其主要化学成分相关性的分析研究[J]. 质量安全与检验检测, 2022, 32(2): 5-8, 51. [Liu AJ, Wang J, Wang XC, et al. Analysis and study on the correlation between total odor and main chemical components of angelica sinensis based on electronic nose technology[J]. Quality Safety Inspection and Testing, 2022, 32(2): 5-8, 51.] http://qikan.cqvip.com/Qikan/Article/Detail?id=7107198312.

41. 梅桂林, 陈娜, 姚洁, 等. 基于电子鼻技术的白术气味与内酯类成分的相关性研究[J]. 皖西学院学报, 2020, 36(5): 81-85. DOI: 10.3969/j.issn.1009-9735. 2020.05.017.

42. 王晓宇, 赵军宁, 吴萍, 等. 基于电子鼻技术对川姜黄整体气味与主要化学成分相关性的初步研究[J]. 中药材, 2019, 42(12): 2850-2855. [Wang XY, Zhao JN, Wu P, et al. Preliminary study on the correlation between overall odor and main chemical compositions of Sichuan curcuma longa based on electronic nose technique[J]. Journal of Chinese Medicinal Materials, 2019, 42(12): 2850-2855.] DOI: 10.13863/j.issn1001-4454.2019.12.022.

43. Qin Y, Li M, Zhang J, et al. Characterization and intrinsic quality correlation of raw and vinegar-processed Curcumae radix[J]. J Pharm Biomed Anal, 2023, 232: 115329. DOI: 10.1016/j.jpba.2023.115329.

44. 冉继春, 吉光见稚代, 秦伟瀚, 等. 石柱产黄连的气味数字化及等级研究[J]. 华西药学杂志, 2024, 39(1): 58-64. [Ran JC, Yoshimitsu M, Qin WH, et al. Study on the digitalization and grade of the odor of Coptis chinensis produced in Shizhu[J]. West China Journal of Pharmaceutical Sciences, 2024, 39(1): 58-64.] DOI: 10.13375/j.cnki.wcjps.2024.01.012.

45. 董彩虹, 胡少伟, 田广环, 等. 基于电子鼻与GC-MS技术的鲜、干鱼腥草的比较研究及腥味成分相关性分析[J]. 中国药物警戒, 2023, 20(12): 1368-1374, 1381. [Dong CH, Hu SW, Tian GH, et al. Comparative study of fresh and dried houttuynia based on the electronic nose and GC-MS technique and correlations between "fishy odor" components[J]. Chinese Journal of Pharmacovigilance, 2023, 20(12): 1368-1374, 1381.] DOI: 10.19803/j.1672-8629.20230056.

46. 陈建真, 陈建明. 中药五味与化学成分及作用关系探讨[J]. 浙江中医学院学报, 1993, (4): 9-10. https://www.cnki.com.cn/Article/CJFDTotal-BHON199304005.htm.

47. 李向高, 刘大有. 试谈中药“四气五味”理论的物质基础[J]. 吉林中医药, 1979, (4): 64-70. DOI: 10.13463/j.cnki.jlzyy.1979.04.027.

48. 张玲, 李宗金, 张亚莉, 等. 木瓜“酸味”与有机酸成分的相关性研究[J]. 中成药, 2023, 45(2): 476-482.[Zhang L, Li ZJ, Zhang YL, et al. Correlation between sour taste and organic acids of Chaenomelis fructus[J]. Chinese Traditional Patent Medicine, 2023, 45(2): 476-482.] DOI: 10.3969/j.issn.1001-1528.2023.02.023.

49. Kong D, Zhang Y, Li X, et al. The material basis of bitter constituents in carbonized Typhae pollen, based on the integration strategy of constituent analysis, taste sensing system and molecular docking[J]. J Pharm Biomed Anal, 2024, 242: 116028. DOI: 10.1016/j.jpba.2024.116028.

50. 荆文光, 赵小亮, 张权, 等. 基于电子舌和多成分定量技术的厚朴“苦味”药性物质基础研究[J]. 中国现代中药, 2022, 24(2): 258-264. [Jing WG, Zhao XL, Zhang Q, et al. Material basis of "Bitterness" medicinal properties of Magnoliae officinalis cortex based on electronic tongue and multi-component quantitative technology[J]. Modern Chinese Medicine, 2022, 24(2): 258-264.] DOI: 10.13313/j.issn.1673-4890.20201026007.

51. 王晓宇, 郭俊霞, 吴萍, 等. 基于电子舌技术的川芎味觉信息与主要化学成分相关性研究[J]. 中药材, 2020, 43(1): 34-41. [Wang XY, Guo JX, Wu P, et al. Study on the correlation between taste information and main chemical compositions of Ligusticum Chuanxiong based on electronic tongue technology[J]. Journal of Chinese Medicinal Materials, 2020, 43(1): 34-41.] DOI: 10.13863/j.issn1001-4454.2020.01.008.

52. 魏子路, 阿卜杜热依木阿丽娅, 孙秀岩, 等. 基于味觉信息和化学成分的“谱味”关系挖掘白术苦味物质基础[J]. 分析测试学报, 2023, 42(8): 952-959. [Wei ZL, Ariya A, Sun X Y, et al. Exploration on bitter substance basis of atractylodes macrocephala rhizoma based on the "Spectral Taste" relationship between taste information and chemical components[J]. Journal of Instrumental Analysis, 2023, 42(8): 952-959.] DOI: 10.19969/j.fxcsxb.23032302.

53. 楚越, 李烨, 雷婧萱, 等. 栀子炒焦前后HPLC多成分含量测定及性味数字化关联分析[J]. 中华中医药杂志, 2022, 37(6): 3416-3422. [Chu Y, Li Y, Lei JX, et al. HPLC multi-component content determination of Fructus gardeniae before and after stir-fried and correlation analysis of digital traits[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2022, 37(6): 3416-3422.] http://qikan.cqvip.com/Qikan/Article/Detail?id=7107678732.

54. 朱丽丽. 基于色谱和电子舌技术研究桔梗苦味物质的组成[D]. 合肥:安徽中医药大学, 2024. DOI: 10.26922/d.cnki.ganzc.2020.000416.

55. 吴杭莎, 杜伟锋, 吕悦, 等. 感官技术在中药饮片质量识别中的研究进展[J]. 中华中医药杂志, 2023, 38(4): 1702-1705. [Wu HS, Du WF, Lv Y, et al. Research progress of sensory technology in quality identification of Chinese herbal pieces[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2023, 38(4): 1702-1705.] https://www.zhangqiaokeyan.com/academic-journal-cn_detail_thesis/02012106873876.html.

56. 刘瑞新, 郝小佳, 张慧杰, 等. 基于电子眼技术的中药川贝母真伪及规格的快速辨识研究[J]. 中国中药杂志, 2020, 45(14): 3441-3451. [Liu RX, Hao XJ, Zhang HJ, et al. A rapid identification of authenticity and specifications of Chinese medicine Fritillariae Cirrhosae Bulbus based on E-eye technology[J]. China Journal of Chinese Materia Medica, 2020, 45(14): 3441-3451.] DOI: 10.19540/j.cnki.cjcmm.20200601.301.

57. 拱健婷, 关佳莉, 李莉, 等. 基于电子鼻技术的黄精霉变快速无损鉴别研究[J]. 现代中药研究与实践, 2023, 37(2): 17-22. [Gong JT, Guan JL, Li L, et al. Rapid and nondestructive recognition of moldy Rhizoma polygonatum using electronic nose[J]. Research and Practice on Chinese Medicines, 2023, 37(2): 17-22.] DOI: 10.13728/j.1673-6427.2023.02.004.

58. 袁铭君, 张恬, 黄晓, 等. 不同霉变程度蟾皮气味检测及表面真菌研究初探[J]. 黑龙江畜牧兽医, 2022, (23): 20-24, 132-133. [Yuan MJ, Zhang T, Huang X, et al. Preliminary study on odor detection and surface fungi of toad skin with different mildew degrees[J]. Heilongjiang Animal Science and Veterinary, 2022, (23): 20-24, 132-133.] DOI: 10.13881/j.cnki.hljxmsy.2022.03.0223.

59. 拱健婷, 赵丽莹, Bauer R, 等. “辨状论质”看中药材苦杏仁走油[J]. 中国中药杂志, 2016, 41(23): 4375-4381. DOI: 10.4268/cjcmm20162314.

60. 陈慧荣. 基于颜色气味数字化及信息融合的苦杏仁走油监测系统的研究[D]. 北京: 北京中医药大学, 2019. https://cdmd.cnki.com.cn/Article/CDMD-10026-1019153462.htm.

61. 陈倩萍, 谢琦, 李文艳, 等. 中药材及其饮片质量等级标准研究进展与展望[J]. 上海中医药杂志, 2023, 57(1): 87-95. [Chen QP, Xie Q, Li WY, et al. Research progress and prospect on quality grade standards of Chinese medicinal materials and TCM decoction pieces[J]. Shanghai Journal of Traditional Chinese Medicine, 2023, 57(1): 87-95.] DOI: 10.16305/j.1007-1334.2022.2207040.

62. 荆文光, 程显隆, 刘安, 等. 基于“辨状论质”综合评价指数的厚朴饮片等级划分和优质优效研究[J]. 中草药, 2021, 52(8): 2285-2293. [Jing WG, Cheng XL, Liu A, et al. Research on grade classification and high quality and superior effect of Magnolia officinalis decoction pieces based on "quality evaluation through morphological identification" and comprehensive evaluation index [J]. Chinese Traditional and Herbal Drugs, 2021, 52(8): 2285-2293.] DOI: 10.7501/j.issn.0253-2670.2021.08.011.

63. Kiani S, Rahimzadeh H, Kalantari D, et al. Aroma modeling and quality evaluation of spearmint (Mentha spicata subsp. spicata) using electronic nose technology coupled with artificial intelligence algorithms[J]. J Appl Res Med Aroma, 2023, 35: 100473. DOI: 10.1016/j. jarmap.2023.100473.

64. 刘书斌, 杨晓玲, 李喜香, 等. 基于性状鉴别与灰色关联法对不同规格大黄饮片质量比较研究[J]. 甘肃中医药大学学报, 2022, 39(2): 1-6. [Liu SB, Yang XL, Li XX, et al. Comparative study on quality of Rhei radix et rhizoma decoction pieces with different specifications based on macroscopic identification and grey relational analysis[J]. Journal of Gansu University of Chinese Medicine, 2022, 39(2): 1-6.] DOI: 10.16841/j.issn1003-8450.2022.02.01.

65. 郭超伟, 徐文丽, 徐荣, 等. 基于“辨状论质”综合评价指数的拳参药材规格等级标准研究[J/OL]. 中华中医药学刊, 2023-11-14. [Guo CW, Xu WL, Xu R, et al. Research on grade classification of based on Polygonum bistorta based on "quality evaluation through morphological identification" and comprehensive evaluation index[J/OL]. Chinese Archives of Traditional Chinese Medicine, 2023-11-14.] https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202409046.htm.

66. 刘锦芮, 赖长江生, 梁嫌, 等. 中药采收期的机理与控制方法的研究进展[J]. 中药材, 2022, 45(8): 2019-2025. DOI: 10.13863/j.issn1001-4454.2022.08.044.

67. 崔治家, 夏鹏飞, 张启立, 等. 电子鼻技术区分不同产地不同采收时间不同处理方法的枸杞子研究[J]. 时珍国医国药, 2019, 30(9): 2163-2166. [Cui ZJ, Xia PF, Zhang QL, et al. Study on distinction of Lycii fructus from different habitats and different harvest time and different processing methods based on electronic nose[J]. Lishizhen Medicine and Materia Medica Research, 2019, 30(9): 2163-2166.] DOI: 10.3969/j.issn.1008-0805.2019. 09.037.

68. 张久旭. 基于质—效关联的黄连采收加工方法研究 [D]. 北京: 北京中医药大学, 2019. https://cdmd.cnki.com.cn/Article/CDMD-10026-1019141280.htm.

69. 裴建国, 刘婧, 付小梅, 等. 不同采收期栀子颜色与其3类有效成分相关性研究[J]. 中药材, 2017, 40(10): 2280-2285. [Pei JG, Liu J, Fu XM, et al. Correlation between color values and compounds of Gardeniae fructus in different harvest period[J]. Journal of Chinese Medicinal Materials, 2017, 40(10): 2280-2285.] DOI: 10.13863/j.issn1001-4454.2017.10.009.

70. Qin Y, Zhao Q, Zhou D, et al. Application of flash GC e-nose and FT-NIR combined with deep learning algorithm in preventing age fraud and quality evaluation of pericarpium citri reticulatae[J]. Food Chem X, 2024, 21: 101220. DOI: 10.1016/j.fochx.2024.101220.

71. 李倩, 何芳, 艾青青, 等. 模拟加速实验研究大黄贮藏过程中颜色变化与药效成分的相关性[J]. 中国实验方剂学杂志, 2019, 25(23): 139-144. [Li Q, He F, Ai QQ, et al. Simulated accelerated test to study correlation between color change in storage and medicinal ingredients of Rhei radix et rhizoma[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2019, 25(23): 139-144.] DOI: 10.13422/j.cnki.syfjx.20191412.

72. 马美杰, 刘孟祥, 薛淑娟, 等. 加速实验过程牛膝成分含量与颜色值相关性研究[J]. 中药材, 2022, 45(3): 579-585. [Ma MJ, Liu MX, Xue SJ, et al. Correlation study between component content and color value of Achyranthis bidentatae radix during accelerated test[J]. Journal of Chinese Medicinal Materials, 2022, 45(3): 579-585.] DOI: 10.13863/j.issn1001-4454.2022.03.012.

73. 赵丽莹. 基于电子鼻技术苦杏仁“走油”预警模型的建立[D]. 北京: 北京中医药大学, 2017. https://cdmd.cnki.com.cn/Article/CDMD-10026-1017201343.htm.

74. Zhang K, Wang J, Fan X, et al. Discrimination between raw and ginger juice processed Magnoliae officinalis cortex based on HPLC and Heracles NEO ultra-fast gas phase electronic nose[J]. Phytochem Anal, 2022, 33(5): 722-734.DOI: 10.1002/pca.3123.

75. Fei C, Ren C, Wang Y, et al. Identification of the raw and processed Crataegi Fructus based on the electronic nose coupled with chemometric methods[J]. Sci Rep, 2021, 11(1): 1849. DOI: 10.1038/s41598-020-79717-w.

76. 杨靖涵, 高杰, 孙立丽, 等. 基于电子鼻技术结合网络药理学分析半夏不同炮制品的气味差异标志物 [J]. 中南药学, 2024, 22(2): 383-391. [Yang JH, Gao  J, Sun LL, et al. Odor differential markers for different processed products of Pinelliae rhizoma by electronic nose combined with network pharmacology[J]. Central South Pharmacy, 2024, 22(2): 383-391.] DOI: 10.7539/j.issn.1672-2981.2024.02.017.

77. 王宏贤, 史可, 王春燕, 等. 白术清炒过程中颜色变化与5-羟甲基糠醛的相关性分析及拐点研究 [J]. 中医药信息, 2024, 41(2): 9-15. [Wang HX, Shi K, Wang  CY, et al. Correlation analysis between color change and 5-HMF and study on processing inflection point in the plain stir-frying process of white atractylodes[J]. Information on TCM, 2024, 41(2): 9-15.] DOI: 10.19656/j.cnki.1002-2406.20240202.

78. 荆文光, 张权, 程显隆, 等. 基于电子鼻、电子舌技术的姜厚朴炮制机理探讨[J]. 河北工业科技, 2021, 38(5): 414-422. [Jing WG, Zhang Q, Cheng XL, et al. Discussion on the processing mechanism of ginger Magnoliae officinalis cortex based on electronic nose and tongue technology[J]. Hebei Journal of Industrial Science and Technology, 2021, 38(5): 414-422.] DOI: 10.7535/hbgykj.2021yx05010.

79. 黄学思, 李文敏, 张小琳, 等. 基于色彩色差计和电子鼻的槟榔炒制火候判别及其指标量化研究[J]. 中国中药杂志, 2009, 34(14): 1786-1791. [Huang XS, Li WM, Zhang XL, et al. Discriminating processed betelnuts degree of stir-frying and quantizing empirical index based on color difference meter and electronic nose fingerprint analyzer[J]. China Journal of Chinese Materia Medica, 2009, 34(14): 1786-1791.] DOI: 10.3321/j.issn:1001-5302.2009. 14.009.

80. 孙静, 孙艺璇, 尹贻慧, 等. 基于形性、化学、生物活性相关联优选黄芩炭炮制终点[J]. 中医药导报, 2023, 29(10): 43-49. [Sun J, Sun YX, Yin YH, et al. Optimization of the processing endpoint of Scutellariae radix carbonisatum based on the correlation analysis of morphological, chemical and biological activities[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2023, 29(10): 43-49.] DOI: 10.13862/j.cn43-1446/r.2023.10.008.

81. 姜宇, 栾雅格, 黄蓉, 等. 不同炮制程度的酒炖和清蒸地黄性状、成分对比研究[J]. 中国现代中药, 2023, 25(9): 1957-1965. [Jiang Y, Luan YG, Huang R, et al. Comparative analysis of characters and components of wine-stewed and steamed Rehmanniae radix with different processing degrees[J]. Modern Chinese Medicine, 2023, 25(9): 1957-1965.] DOI: 10.13313/j.issn.1673-4890. 20230104006.

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