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The impact of dapagliflozin on blood glucose and cognitive function in type 2 diabetes patients with ischemic stroke

Published on Nov. 08, 2024Total Views: 398 times Total Downloads: 43 times Download Mobile

Author: YU Meiling 1 ZHANG Xiao 2 LI Ping 3

Affiliation: 1. Three Wards of Vascular Neurology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100071, China 2. Department of Brain Disease, Beijing Traditional Chinese Medicine Hospital Huairou Hospital, Beijing 101400, China 3. Three Department of Neurology, Hunan Provincial Brain Hospital, Changsha 410021, China

Keywords: Dapagliflozin Type 2 diabetes Ischemic stroke Blood glucose Cognitive function

DOI: 10.12173/j.issn.2097-4922.202406045

Reference: YU Meiling, ZHANG Xiao, LI Ping.The impact of dapagliflozin on blood glucose and cognitive function in type 2 diabetes patients with ischemic stroke[J].Yaoxue QianYan Zazhi,2024, 28(2):192-199.DOI: 10.12173/j.issn.2097-4922.202406045.[Article in Chinese]

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Abstract

Objective  To explore the effects of dapagliflozin on blood glucose and cognitive function in patients with type 2 diabetes mellitus (T2DM) and ischemic stroke (IS).

Methods  Patients with T2DM and IS admitted to the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University from January 2022 to January 2023 were collected and randomly divided into dapagliflozin group (conventional treatment + dapagliflozin) and control group (conventional treatment+metformin) for 6 months of continuous treatment. Blood glucose control levels and fluctuations were compared before and after treatment. The Montreal Cognitive Assessment (MoCA) was used to evaluate cognitive function before and after treatment.

Results  A total of 100 patients were included in the study, 50 in the dapagliflozin group and 50 in the control group. After 6 months of treatment, blood glucose levels and fluctuations decreased in both groups (P<0.05), but were lower in the dapagliflozin group (P<0.05). Regarding cognitive function, MoCA scores increased in both groups, with the dapagliflozin group showing higher scores, especially in visuospatial executive function and delayed recall (P<0.05).

Conclusion  Dapagliflozin can effectively control blood glucose levels and fluctuations in T2DM patients with IS, and improve cognitive function, particularly in visuospatial executive function and delayed recall.

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References

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