Objective  To explore the efficacy of ursodeoxycholic acid capsules (UAC) combined with health education based on listen-establish-establish-adopt-reinforce-name-strengthen model (HE-LEARNS) in patients undergoing laparoscopic biliary lithotomy.

Methods  Clinical data of patients after laparoscopic biliary lithotomy at Hangzhou Hospital of Traditional Chinese Medicine from January 2021 to January 2023 were analyzed. Patients were divided into a control group (UAC combined with routine education) and a experimental group (UAC combined with HE-LEARNS) based on postoperative intervention plans. The primary observation index was the 12-month gallstone recurrence rate. Secondary observation indices included cholesterol metabolism indicators [total cholesterol (TC) and triglyceride (TG)], gallbladder-related indicators (gallbladder wall thickness and gallbladder contraction rate), the quality of life [gastrointestinal quality of life index, (GIQ-LI) score], medication adherence [Morisky medication adherence scale (MMAS) score], and changes in liver and kidney function [aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum creatinine (SCr), and blood urea nitrogen (BUN)].

Results  A total of 119 patients were included in the study, with 50 in the experimental group and 69 in the control group. The 12-month recurrence rate of gallbladder stones was lower in the experimental group than in the control group (P<0.05). After 2 months of treatment, TC, TG, gallbladder wall thickness were lower in the experimental group than in the control group, and gallbladder contraction rate was higher in the experimental group than in the control group (P<0.05), and GIQ-LI score and MMAS score of the experimental group were higher than those of the control group (P<0.05); the differences in AST, ALT, SCr and BUN between the two groups were not statistically significant (P>0.05)

Conclusion  UAC combined with HE-LEARNS is significantly effective in the treatment of patients after laparoscopic biliary lithotomy, which can improve the quality of life and medication compliance of patients, improve cholesterol metabolism, gallbladder structure and function, and reduce the recurrence rate of stones at 12 months.

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