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Research progress on chemical constituents, pharmacological effects and toxicity of Dictamni cortex

Published on Nov. 08, 2024Total Views: 474 times Total Downloads: 44 times Download Mobile

Author: HU Wenkai 1 XU Xiaomin 1 JIANG Xin 1 WO Jiameixue 1 JIA Suxia 1 LIU Shumin 2 LU Fang 2

Affiliation: 1. Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China 2. Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China

Keywords: Dictamni cortex Chemical constituents Pharmacological effects Toxicity Research progress Alkaloids Sesquiterpenes Limonoids Fatty acids

DOI: 10.12173/j.issn.2097-4922.202406157

Reference: HU Wenkai, XU Xiaomin, JIANG Xin, WO Jiameixue, JIA Suxia, LIU Shumin, LU Fang.Research progress on chemical constituents, pharmacological effects and toxicity of Dictamni cortex[J].Yaoxue QianYan Zazhi,2024, 28(2):252-267.DOI: 10.12173/j.issn.2097-4922.202406157.[Article in Chinese]

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Abstract

Dictamni cortex is the root bark of Rutaceae plants. It is the main medicinal part and the key drug of ‘Zhuhuang Fengbi’. It has the effects of clearing heat and detoxifying, dispelling wind and drying dampness, and relieving itching. Dictamni cortex mainly contains 228 chemical components such as alkaloids, sesquiterpenes, limonoids, fatty acids, volatile oils, flavonoids, steroids, etw. Its pharmacological activities in vivo and in vitro include antibacterial activity, anti-inflammatory activity, hepatoprotective activity, cardiovascular protection activity, insecticidal activity, anticancer activity, anti-allergic activity, and improvement of gastrointestinal activity. It has been reported that Dictamni cortex also has potential hepatotoxicity, among which dictamnine, fraxinellone and limonin compounds are potential hepatotoxic components. In this paper, the chemical constituents, pharmacological effects and toxicity of Dictamni cortex are reviewed by consulting domestic and foreign literature, to provide theoretical support for the clinical rational application and related product development of Dictamni cortex.

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References

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