Synergistic effect of Yinzhihuang oral liquid on blue light irradiation combined with Saccharomyces boulardii powder in the treatment of neonatal jaundice

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Author: GONG Fangfang GONG Meiqiao MAN Yun  JI Jianwei

Affiliation: Department of Neonatology, Yiwu Central Hospital, Yiwu 322000, Zhejiang Province, China

Keywords: Yinzhihuang oral liquid Saccharomyces boulardii powder Neonatal jaundice Myocardial function Blood gas index

DOI: 10.12173/j.issn.2097-4922.202408033

Reference: GONG Fangfang, GONG Meiqiao, MAN Yun, JI Jianwei.Synergistic effect of Yinzhihuang oral liquid on blue light irradiation combined with Saccharomyces boulardii powder in the treatment of neonatal jaundice[J].Yaoxue QianYan Zazhi,2024, 28(3):458-464.DOI: 10.12173/j.issn.2097-4922.202408033.[Article in Chinese]  Copied

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Abstract

Objective To evaluate the synergistic effect of Yinzhihuang oral liquid on blue light irradiation combined with Saccharomyces boulardii powder in the treatment of neonatal jaundice.

Methods The data of children with neonatal jaundice admitted to Yiwu Central Hospital from January 2022 to January 2024 were retrospectively analyzed. Patients were divided into the experimental group and the control group according to the treatment plans. The myocardial function [creatine kinase isoenzyme (CK-MB), creatine kinase (CK) and cardiac troponin I (cTnI)], blood gas indexes [partial pressure of oxygen (PaO₂), partial pressure of carbon dioxide (PaCO₂) and pH value], symptom improvement, efficacy and incidence of adverse reactions were compared between the two groups.

Results A total of 180 children were included in the study, with 90 in each group. The effective rate of the experimental group was higher than that of the control group, and the incidence of adverse reactions was lower than that of the control group (P<0.05). After treatment, the levels of CK, CK-MB, cTnI and PaCO₂ in the two groups were lower than those before treatment, and the experimental group was lower than the control group (P<0.05); the levels of pH and PaO₂ in the two groups increased, and the experimental group was higher than the control group (P<0.05). The improvement time of each symptom and the number of bowel movements per day in the experimental group were smaller than that in the control group (P<0.05).

Conclusion Yinzhihuang oral liquid combined with Saccharomyces boulardii powder can effectively improve the myocardial function, regulate blood gas, improve the curative effect of children with neonatal jaundice, and is with good safety.

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References

1.胡忠华, 林振浪. 新生儿黄疸早期筛查的研究进展 [J]. 中华围产医学杂志, 2024, 27(6): 511-515. [Hu ZH, Lin ZL. Research progress in early screening for neonatal jaundice[J]. Chinese Journal of Perinatal Medicine, 2024, 27(6): 511-515.] DOI: 10.3760/cma.j.cn113903-20230905-00187.

2.晁小云. 新生儿高胆红素血症早期预测及筛查方法研究进展[J]. 实用临床医药杂志, 2020, 24(15): 129-132. [Chao XY. Progress of methods for early prediction and screening of neonatal hyperbilirubinemia[J]. Journal of Clinical Medicine in Practice, 2020, 24(15): 129-132.] DOI: 10.7619/jcmp.202015037.

3.《中成药治疗优势病种临床应用指南》标准化项目组. 中成药治疗新生儿黄疸临床应用指南(2020年) [J]. 中国中西医结合杂志, 2021, 41(3): 280-285. DOI: 10.7661/j.cjim.20210114.161.

4.冯慧玲, 冯孝强, 李帆, 等. 低剂量维生素D辅助蓝光治疗新生儿黄疸的单中心随机对照研究[J]. 中国妇幼健康研究, 2023, 34(4): 74-79. [Feng HL, Feng XQ, Li F, et al. Low-dose vitamin D supplementation combined with blue light radiation for treatment of neonatal jaundice: a single-center randomized controlled study[J]. Chinese Journal of Woman and Child Health Research, 2023, 34(4): 74-79.] DOI: 10.3969/j.issn.1673-5293.2023.04.012.

5.郭健, 王文涛, 周启力. 茵栀黄口服液、还原型谷胱甘肽联合光疗对新生儿黄疸患者的临床疗效[J]. 中成药, 2022, 44(1): 83-87. [Guo J, Wang WT, Zhou QL. Clinical effects of Yinzhihuang oral liquid and reduced glutathione combined with phototherapy on patients with neonatal jaundice[J]. Chinese Patent Medicine, 2022, 44(1): 83-87.] DOI: 10.3969/j.issn.1001-1528.2022.01.016.

6.张艳, 曹璐, 刘廷亮. 蓝光与布拉氏酵母菌联合治疗新生儿黄疸疗效及安全性分析[J]. 数理医药学杂志, 2022, 35(2): 236-238. [Zhang Y, Cao L, Liu TL. Analysis of the efficacy and safety of blue light combined with Saccharomyces boulardii in the treatment of neonatal jaundice[J]. Journal of Mathematical Medicine, 2022, 35(2): 236-238.] DOI: 10.3969/j.issn.1004-4337.2022.02.026.

7.中华医学会儿科学分会新生儿学组, 《中华儿科杂志》编辑委员会. 新生儿高胆红素血症诊断和治疗专家共识[J]. 中华儿科杂志, 2014, 52(10): 745-748. DOI: 10.3760/cma.j.issn.0578-1310.2014.10.006.

8.李秋平, 封志纯. 美国儿科学会最新新生儿黄疸诊疗指南[J]. 实用儿科临床杂志, 2006, 21(14): 958-960. [Li QP, Feng ZC. The Latest guideline for neonatal jaundice produced by American Academic of Pediatrics[J]. Journal of Applied Clinical Pediatrics Journal, 2006, 21(14): 958-960.] DOI: 10.3969/j.issn.1003-515X.2006.14.043.

9.彭程, 侯新琳. 《2018昆士兰产科与新生儿临床指南：新生儿黄疸》要点介绍[J]. 中华围产医学杂志, 2020, 23(4): 285-288. DOI: 10.3760/cma.j.cn113903-20190624-00399.

10.胡冰, 康乐, 周栩平, 等. 驻马店市新生儿黄疸发生情况及其影响因素[J]. 华南预防医学, 2021, 47(2): 162-165. [Hu B, Kang L, Zhou XP, et al. Incidence and influencing factors of neonatal jaundice in Zhumadian city[J]. South China Journal of Preventive Medicine, 2021, 47(2): 162-165.] DOI: 10.12183/j.scjpm.2021.0162.

11.张杰, 李臻, 吴芳, 等. 新生儿黄疸431例病因及临床特点分析[J]. 肝脏, 2021, 26(6): 677-679. [Zhang J, Li Z, Wu F, et al. Analysis of etiology and clinical features of 431 cases of neonatal jaundice[J]. Chinese Hepatology, 2021, 26(6): 677-679.] DOI: 10.3969/j.issn.1008- 1704.2021.06.027.

12.赵璇珠, 陈旭升, 黄晓冬, 等. 茵栀黄颗粒、布拉氏酵母菌散联合蓝光照射治疗新生儿黄疸的疗效及对血清TRF和CRP水平的影响[J]. 海南医学, 2021, 32(15): 1986-1989. [Zhao XZ, Chen XS, Huang XD, et al. Efficacy of Yinzhihuang granule, Saccharomyces boulardii powder combined with blue light irradiation in the treatment of neonatal jaundice and its influence on serum transferrin and C-reactive protein levels[J]. Hainan Medical, 2021, 32(15): 1986-1989.] DOI: 10.3969/j.issn.1003-6350.2021.15.022.

13.王洁洁, 王国凯. 茵栀黄口服液联合双歧杆菌四联活菌治疗新生儿黄疸的效果分析[J]. 中华全科医学, 2022, 20(7): 1158-1161. [Wang JJ, Wang GK. Analysis of the curative effect of Yinzhihuang oral liquid combined with bifidobacterium tetragenous viable bacteria in the treatment of neonatal jaundice[J]. Chinese Journal of General Practice, 2022, 20(7): 1158-1161.] DOI: 10.16766/j.cnki.issn.1674-4152.002547.

14.彭研献, 董晓斐, 周娅微, 等. 茵栀黄口服液联合枯草杆菌二联活菌颗粒辅助治疗新生儿黄疸的疗效及对免疫功能和生长发育的影响[J]. 现代生物医学进展, 2021, 21(19): 3748-3751, 3800. [Peng YX, Dong XF, Zhou YW, et al. Effect of Yinzhihuang oral liquid combined with live bacillus subtilis particles in adjuvant treatment of neonatal jaundice and its influence on immune function and growth and development[J]. Progress in Modern Biomedicine, 2021, 21(19): 3748-3751, 3800.] DOI: 10.13241/j.cnki.pmb.2021.19.030.

15.陈巘, 梁桂娟, 李永安. 茵栀黄口服液联合布拉氏酵母菌散及间歇蓝光照射治疗新生儿黄疸的效果观察[J]. 临床医学, 2020, 40(11): 121-122. [Chen Y, Liang GJ, Li YA. Observation on the effect of Yinzhihuang oral liquid combined with Saccharomyces boulardii powder and intermittent blue light irradiation on neonatal jaundice[J]. Clinical Medicine, 2020, 40(11): 121-122.] DOI: 10.19528/j.issn.1003-3548.2020.11.049.

16.陈淑珍, 张丽范, 陈海山. 茵栀黄口服液联合布拉酵母菌治疗新生儿黄疸的临床效果观察[J]. 吉林医学, 2020, 41(5): 1118-1120. [Chen SZ, Zhang LF, Chen HS. Clinical observation of Yinzhihuang oral liquid combined with Saccharomyces boulardii in the treatment of neonatal jaundice[J]. Jilin Medicine, 2020, 41(5): 1118-1120.] DOI: 10.3969/j.issn.1004-0412.2020.05.032.

17.陈晓东, 陈崇新, 罗丹. 布拉酵母菌散联合茵栀黄口服液治疗新生儿黄疸的临床效果[J]. 临床合理用药杂志, 2022, 15(8): 111-113. [Chen XD, Chen CX, Luo D. Clinical effect of Bladder yeast powder combined with Yinzhihuang oral liquid on neonatal jaundice[J]. Chinese Journal of Clinical Rational Drug Use, 2022, 15(8): 111-113.] DOI: 10.15887/j.cnki.13-1389/r.2022.08.034.

18.杜文琼, 王珍. 茵栀黄口服液联合还原型谷胱甘肽治疗新生儿黄疸的临床研究[J]. 现代药物与临床, 2020, 35(1): 138-142. [Du WQ, Wang Z. Clinical study on Yinzhihuang oral liquid combined with reduced glutathione in treatment of neonatal jaundice[J]. Drugs & Clinic, 2020, 35(1): 138-142] DOI: 10.7501/j.issn.1674-5515.2020.01.029.

19.曲倩文, 陈勇, 周波, 等. 茵栀黄口服液联合枯草杆菌二联活菌颗粒辅助治疗新生儿黄疸临床效果观察[J]. 临床误诊误治, 2020, 33(7): 31-34. [Qu QW, Chen Y, Zhou B, et al. Clinical efficacy of adjuvant therapy of Yinzhihuang oral liquid combined with live combined Bacillus subtilis in the treatment of neonatal jaundice[J]. Clinical Misdiagnosis & Mistherapy, 2020, 33(7): 31-34.] DOI: 10.3969/j.issn.1002-3429.2020.07.009.

20.刘蕾. 茵栀黄联合微生态生物制剂治疗新生儿黄疸对新生儿甲状腺功能的影响[J]. 检验医学与临床, 2021, 18(4): 544-547. [Liu L. Effect of Yinzhihuang combined with microecological biological agents on neonatal thyroid function[J]. Laboratory Medicine and Clinic, 2021, 18(4): 544-547.] DOI: 10.3969/j.issn.1672-9455.2021.04.036.

21.熊兰兰. 茵栀黄颗粒布拉氏酵母菌散联合蓝光照射治疗新生儿黄疸的疗效及对胆红素水平的影响[J]. 实用医技杂志, 2021, 28(4): 501-503. [Xiong LL. The curative effect of Yinzhihuang granule Brucella yeast powder combined with blue light irradiation on neonatal jaundice and its influence on bilirubin level[J]. Journal of Practical Medical Techniques, 2021, 28(4): 501-503.] DOI: 10.19522/j.cnki.1671-5098.2021.04.026.

22.刘媛, 李荟. 茵栀黄口服液联合西药治疗新生儿病理性黄疸及对患儿凝血指标、血气指标的影响[J]. 血栓与止血学, 2021, 27(2): 239-241. [Liu Y, Li H. Effect of Yinzhihuang oral liquid combined with western medicine in the treatment of neonatal pathological jaundice[J]. Chinese Journal of Thrombosis and Hemostasis, 2021, 27(2): 239-241.] DOI: 10.3969/j.issn.1009-6213.2021.02.021.