Objective  To explore the efficacy and mechanism of mometasone furoate nasal spray combined with acupoint application and auricular acupoint pressing beans in the treatment of patients with allergic rhinitis (AR).

Methods  The clinical data of AR patients treated in The Third People's Hospital of Beilun District, Ningbo City from January 2023 to October 2023 were retrospectively collected. According to different diagnosis and treatment schemes, the patients were divided into the conventional treatment group (mometasone furoate nasal spray) and the combined treatment group (mometasone furoate nasal spray combined with acupoint application and auricular acupoint pressing beans). The total score of clinical symptoms, effective rate, rhinoconjunctivitis quality of life score (RQLQ), T lymphocyte subsets (CD3⁺, CD4⁺ and CD8⁺), total immunoglobulin E (tIgE), interleukin-6 (IL- 6), whole blood eosinophil count (EOS), and nasal mucosal EOS were compared between the two groups.

Results  A total of 100 patients were included, with 49 in the combined treatment group and 51 in the conventional treatment group. Compared with before treatment, the total clinical symptom scores and RQLQ scores of AR patients in both groups decreased significantly after treatment (P<0.05), and the total clinical symptom scores and RQLQ scores of the combined treatment group were significantly lower than those in the conventional treatment group (P<0.05). The effective rate of the combined treatment group was significantly higher than that of the conventional treatment group (91.84% vs. 74.51%, P<0.05). In terms of inflammatory immune regulation, compared with before treatment, the levels of CD3⁺ and CD4⁺ of AR patients in both groups increased significantly after treatment (P<0.05), and the levels of CD3⁺ and CD4⁺ in the combined treatment group were significantly higher than those in the conventional treatment group (P<0.05); the levels of CD8⁺, tIgE, IL-6, whole blood EOS and nasal mucosal EOS decreased significantly (P<0.05), and the levels of CD8⁺, tIgE, IL-6, whole blood EOS and nasal mucosal EOS in the combined treatment group were significantly lower than those in the conventional treatment group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P﹥0.05).

Conclusion  Mometasone furoate nasal spray combined with acupoint application and auricular acupoint pressing beans is more effective than mometasone furoate nasal spray in the treatment of AR, and can significantly improve the clinical symptoms and quality of life of AR patients. Its possible mechanism is to inhibit B lymphocyte activity and inflammatory response, thereby inhibiting IgE-mediated type 1 hypersensitivity reaction.

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