Objective  To optimize the optimal inclusion process for Ramulus cinnamomi volatile oil and optimize key parameters.

Methods  Using the comprehensive evaluation score of Ramulus cinnamomi volatile oil as the assessment index, with β-cyclodextrin as the inclusion carrier, the Plackett-Burman design was used to screen key influencing factors and the Box-Behnken response surface methodology was used to optimize the inclusion process parameters, ultimately determining the optimal inclusion conditions.

Results  Ramulus cinnamomi volatile oil was prepared using saturated aqueous solution method, and the optimal process parameters were as follows: the feed ratio of 16 ∶ 1 between β-cyclodextrin and Ramulus cinnamomi volatile oil, the inclusion temperature of 53℃, and the inclusion time of 30 minutes.

Conclusion  The inclusion process established in this study has good encapsulation effect, stable process, and good reproducibility, which is suitable for industrial production.

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