Clinical observation of vitamin D2 soft capsules in puerperae with severe preeclampsia

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Affiliation: Department of Obstetrics, Hangzhou Linping District Traditional Chinese Medicine Hospital, Linping 311106, Zhejiang Province, China

Keywords: Severe preeclampsia Vitamin D2 soft capsules Coagulation function Oxidative stress Pregnancy outcome

DOI: 10.12173/j.issn.2097-4922.202507003

Reference: CHENG Junjun, HUANG Jiaqi. Clinical observation of vitamin D2 soft capsules in puerperae with severe preeclampsia[J]. Yaoxue QianYan Zazhi, 2025, 29(9): 1529-1536. DOI: 10.12173/j.issn.2097-4922.202507003.[Article in Chinese]  Copied

Abstract
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Abstract

Objective To explore the clinical efficacy of vitamin D₂ soft capsules in puerperae with severe preeclampsia (PE).

Methods The clinical data of pregnant women with severe PE who visited the obstetrics department of Linping District Hospital of Traditional Chinese Medicine in Hangzhou from January 2021 to December 2024 were retrospectively analyzed. The women were divided into a vitamin D group and a conventional treatment group according to whether they used vitamin D₂ soft capsules. The clinical efficacy, coagulation function indicators [prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D), and fibrinogen (FIB)], oxidative stress indicators [activities of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA), and protein oxidation products (AOPP)], placental hypoxia cytokine indicators [placental growth factor (PLGF), pregnancy-associated plasma protein A (PAPP-A), and soluble endothelial growth factor (sEng) levels], vascular endothelial factor indicators [endothelin-1 (ET-1) and nitric oxide (NO)], 25-hydroxyvitamin D₂ [25 (OH) D], and pregnancy outcomes were compared between the two groups.

Results A total of 118 patients were included, 59 in each group. The treatment efficiency of the Vitamin D group was significantly higher than that of the conventional treatment group (91.53% vs. 76.27%, P<0.05). After treatment, PT, APTT, SOD, GSH-Px, PLGF, PAPP-A, NO, and 25(OH)D in the Vitamin D group were significantly higher than those in the conventional treatment group (P<0.05), while D-D, FIB, MDA, AOPP, sEng, and ET-1 were significantly lower (P<0.05). Additionally, the incidence of adverse pregnancy outcomes in the Vitamin D group was significantly lower than that in the conventional treatment group (3.39% vs. 13.56%, P<0.05).

Conclusion Vitamin D₂ soft capsules can optimize the treatment effect of pregnant women with severe PE and provide new ideas for clinical intervention.

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