As a traditional Chinese medicine, Semen Armeniacae Amarum has the effects of relieving cough and asthma, moistening dryness and promoting bowel movements, and it has been found to have anti-cancer effects in modern pharmacological research. In this paper, we first analyzed and summarized the chemical constituents of Semen Armeniacae Amarum, including many bioactive components, such as glycosides, fats, volatile oils, flavonoids, phenolic acids, phenylpropanoids, amino acids, proteins, vitamins and trace elements. Secondly, the experimental progress and clinical application of Semen Armeniacae Amarum and amygdalin against lung cancer in vitro and in vivo were summarized. Finally, we employed modern network pharmacology to predict its anti-lung cancer targets and pathways, and preliminarily analyzed the potential role of core targets in the treatment and prognosis of non-small cell lung cancer patients, providing valuable insights for its in-depth development as a novel drug for tumor prevention and treatment.

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