Objective To analyze the research status, hotspots, and trends ofPeperomia dindygulensis using bibliometric methods, and to provide references for further research.

Methods Chinese and English literatures concerningPeperomia dindygulensis were systematically retrieved from the China National Knowledge Infrastructure (CNKI) and Web of Science (WOS) databases from inception to January 2025. CiteSpace 6.3.R1 software was adopted to visualize the research onPeperomia dindygulensis, including annual publication trends, publishing institutions, author collaboration networks, as well as keyword co-occurrence, clustering, timeline mapping and burst detection analyses.

Results A total of 52 initial literatures related toPeperomia dindygulensis were retrieved, and 41 literatures were finally included after screening (17 in Chinese and 24 in English). The annual publication output of studies onPeperomia dindygulensis remained at a low level with minor overall fluctuations. Leading publishing institutions were the Academy of Military Medical Sciences (4 publications) and China Pharmaceutical University (8 publications). Core authors included Chen Li (4 articles) and Wang XZ (7 articles). The core Chinese keywords werePeperomia dindygulensis, chemical constituents and content determination, forming 4 keyword clusters. The dominant English keywords werePeperomia dindygulensis, secolignans and peperomine, generating 8 keyword clusters. Timeline mapping revealed that domestic Chinese research mainly focused on the screening of chemical constituents, while international studies centered on molecular pharmacology such as the anti-tumor activity and DNA methyltransferase inhibitory effects of secolignans. Burst analysis indicated that Chinese research hotspots had short sustained cycles, lacking long-term research focuses on active ingredients and pharmacological mechanisms. In contrast, English research hotspots have concentrated on chemical constituents (represented by secolignans) and their pharmacological activities including anti-tumor and anti-virus effects.

Conclusion Research onPeperomia dindygulensis has established a preliminary framework and shows potential for multi-target pharmacological activities. However, the scale of research remains limited, and studies on mechanisms of action and translational applications need to be deepened. Future research should focus on clarifying the mechanisms of active monomers, optimizing extraction processes, and promoting preclinical and clinical studies.

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