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Home Articles Vol 30,2026 No.8 Detail

Research progress on pharmacological effects and underlying mechanisms of plant polysaccharides in the intervention of chronic obstructive pulmonary disease

Published on Sep. 04, 2026Total Views: 1405 times Total Downloads: 295 times Download Mobile

Author: QIN Chen 1 YANG Jie 2 ZHU Dongliang 1 YUAN Jiangling 3

Affiliation: 1.Xinjiang Military Region Security Department Drugs and Instruments Supervision and Inspection Station,Urumqi830000,China 2.School of Public Health, Xinjiang Medical University,Urumqi830000,China 3.Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Xinjiang Uygur Autonomous Region Academy of Preventive Medicine,Urumqi830000,China

Keywords: Chronic obstructive pulmonary disease Plant polysaccharides Immunomodulation Antioxidant Promotion of pulmonary tissue repair

DOI: 10.12173/j.issn.2097-4922.202606003

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Abstract

Chronic obstructive pulmonary disease (COPD), a highly prevalent chronic respiratory disease worldwide. However, current clinical intervention strategies remain limited by frequent adverse reactions induced by long-term medication and the inability to reverse the chronic progressive airway injury. With the natural bioactive advantages of low toxicity and multi-target regulatory effects, plant polysaccharides have received increasing research attention in the field of COPD intervention in recent years. This review systematically summarizes recent research progress from four dimensions: anti-inflammation and immune activation, oxidative stress regulation, gut microbiota modulation, and lung tissue repair. This review highlights the mechanisms by which plant polysaccharides intervene in COPD through key pathways, including correcting the T helper 17 cell/regulatory T cell (Th17/Treg) immune imbalance, regulating phosphatidylinositol 3-kinase/protein kinase B/nuclear factor κB (PI3K/AKT/NF- κappa B) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) inflammatory signaling pathways, activating the nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) antioxidant pathway, and inhibiting ferroptosis. Meanwhile, the translational bottlenecks existing in this field, such as low oral bioavailability, complex action mechanisms, and potential allergic risks, were objectively analyzed. This review aims to provide a systematic reference for subsequent fundamental research and clinical transformation of plant polysaccharides in the prevention and treatment of COPD.

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References

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