Objective  To explore the effects of Xueshuantong combined with gastrodin on vascular endothelial function and inflammatory factors in patients with posterior circulation ischemic vertigo (PCIV).

Methods  Patients with PCIV who were admitted to Qidong People's Hospital from December 2020 to November 2022 were randomly divided into experimental group and control group. The control group was given 300 mg intravenous injection of Xueshuantong, and the experimental group was given intravenous injection of 0.6 g of gastrodin on the basis of thrombotong, and both groups were treated for 15 days. The UCLA-DDQ and VVAS scores were used to evaluate the treatment of vertigo symptoms before and after intervention in the two groups. Serum homocysteine (Hcy), endothelin-1 (ET-1) and nitric oxide (NO) were detected in the two groups to evaluate vascular endothelial function. The levels of inflammation were assessed by measuring serum high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) concentrations. Color Doppler ultrasound system was used to record the mean blood flow velocity of the basilar artery, left vertebral artery and right vertebral artery.

Results  A total of 96 PCIV patients were included in the study, with 48 cases in each group. After treatment, the scores of UCLA-DQ and VVAS in the experimental group were lower than those in the control group (P<0.05), and the blood Hcy, ET-1, hs-CRP, TNF-α and IL-6 levels in the experimental group were lower than those in the control group (P<0.05), but the NO level was higher than that in the control group (P<0.05), and the mean blood flow velocity of basilar artery, left vertebral artery and right vertebral artery in the experimental group was higher than that in the control group (P<0.05).

Conclusion  Xueshuantong combined with gastrodin can significantly improve vertigo symptoms, protect vascular endothelial function, inhibit inflammatory factors and promote the improvement of cerebral hemodynamic indexes in PCIV patients.

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