This article reports a case of suspected drug-induced kidney injury in a chronic disease patient during hospital treatment. Clinical pharmacists reviewed relevant literature and evaluated and analyzed it, considering it to be related to the improper use of valaciclovir. According to the advice of the clinical pharmacist, the dosage of valaciclovir was adjusted according to the patient's real-time creatinine clearance rate, and treatment measures such as fluid replacement and diuresis were given. The patient's renal function and other indicators decreased. After 6 weeks of discharge, outpatient follow-up showed stable renal function indicators. It reminds the medical staff when valaciclovir is used in patients with chronic kidney disease, it is necessary to closely monitor changes in renal function, and adjust the dosage timely, supplement appropriate fluids during medication, and ensure sufficient urine volume to avoid acute kidney damage caused by drug crystallization deposition in the renal tubules.

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