Objective  To prepare quercetin nanocrystals, improve their dissolution rate, and investigate the effects of different stabilizer types and ratios on the stability of nanocrystals.

Methods  Quercetin nanocrystals were prepared by solvent ultrasonication, and three different stabilizers (polyvinylpyrrolidone-K30, poloxamer F188 and sodium dodecyl sulfate) were compared. The particle size was used as a screening index to investigate the stability of placement, the microscopic morphology of nanocrystals was characterized by scanning electron microscopy, infrared spectroscopy and X-ray diffraction, and the mechanism of action between stabilizers and nanocrystals was discussed.

Results  Through experimental screening, the results showed that povidone K30 had the best stable performance, the nanocrystals were also in the form of rod crystals, and the dissolution rate of nanocrystals was significantly higher than that of active pharmaceutical ingredients.

Conclusion  The type and amount of stabilizer will affect the stability of nanocrystals.

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