Welcome to visit Zhongnan Medical Journal Press Series journal website!

Home Articles Vol 28,2024 No.4 Detail

Research progress of pharmacological effects of resveratrol and its derivatives on photodermatoses

Published on Jan. 05, 2025Total Views: 534 times Total Downloads: 63 times Download Mobile

Author: YUAN Ruiying 1 GUI Mingan 1 YANG Guibin 1 WANG Sicen 1, 2

Affiliation: 1. Department of Pharmacy, College of Medicine, Tibet University, Lhasa 850001, China 2. School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China

Keywords: Resveratrol Skin aging Skin inflammation and oxidation Autophagy regulation Pigment deposition Photo-induced skin cancer Pharmacological action

DOI: 10.12173/j.issn.2097-4922.202406023

Reference: YUAN Ruiying, GUI Mingan, YANG Guibin, WANG Sicen.Research progress of pharmacological effects of resveratrol and its derivatives on photodermatoses[J].Yaoxue QianYan Zazhi,2024, 28(4):719-728.DOI:10.12173/j.issn.2097-4922.202406023. [Article in Chinese]

  • Abstract
  • Full-text
  • References
Abstract

Resveratrol (Res), a polyphenolic compound found in natural plants, has various pharmacological activities including anti-inflammatory, antioxidant, anticancer, neuroprotective effects, regulation of lipid metabolism, and improvement of cardiovascular diseases. In recent years, research on the improvement and treatment of skin diseases by natural products and active ingredients has been increasing, and the excellent therapeutic performance of Res in skin diseases has received widespread attention. Studies have shown that Res has good therapeutic effects on photodermatoses caused by ultraviolet light, and this is closely related to signaling pathways such as p38/MAPK/MMP, NF-κB/TNF-α, p53/AMPK, and Nrf2. This paper reviews the effects of Res and its derivatives on anti-inflammation, antioxidation, regulation of autophagy, delaying photoageing, regulation of skin cell immunity, improvement of photoaged skin cancer, and inhibition of skin pathogens, with the premise of ultraviolet protection. It is expected to provide reference for further research on the effects of Res on photodermatoses.

Full-text
Please download the PDF version to read the full text: download
References

1.Farley A, McLafferty E, Hendry C. The anatomy and physiology of the locomotor system[J]. Nurs Stand, 2012, 27: 35-43. DOI: 10.7748/ns2012.10.27.7.35.c9358.

2.Franco AC, Aveleira C, Cavadas C. Skin senescence: mechanisms and impact on whole-body aging[J]. Trends Mol Med, 2022: 28(2): 97-109. DOI: 10.1016/j.molmed.2021.12.003.

3.Trautinger F. Mechanisms of photodamage of the skin and its functional consequences for skin ageing[J]. Clin Exp Dermatol, 2001, 26(7): 573-577. DOI: 10.1046/j.1365-2230.2001.00893.x.

4.Khoo SW, Tay YK, Tham SN. Photod ermatoses in a Singapore skin referral centre[J]. Clin Exp Dermatol, 1996, 21(4): 263-268. DOI: 10.1111/j.1365-2230.1996.tb00090.x.

5.Fu TT, Sun YB, Gao W, et al. The highest-elevation frog provides insights into mechanisms and evolution of defenses against high UV radiation[J]. Proc Natl Acad Sci U S A. 2022, 119(46): e2212406119. DOI: 10.1073/pnas.2212406119.

6.李雅静, 沈洪云, 兰梦, 等. 人参对光损伤皮肤的保护作用及研究现状[J]. 人参研究, 2024, 36(2): 56-59. [Li YJ, Shen HY, Lan M, et al. The protective effect of ginseng on photodamaged skin and its research status  [J]. Renshen Yanjiu, 2024, 36(2): 56-59.] DOI: 10.19403/j.cnki.1671-1521.2024.02.014.

7.Colica C, Milanović M, Milić N, et al. A systematic review on natural antioxidant properties of resveratrol[J]. Nat Prod Comm, 2018, 13(9): 1195-1203. DOI: 10.1177/1934578X1801300923.

8.Ovesná Z, Horváthová-Kozics K. Structure-activity relationship of trans-resveratrol and its analogues[J]. Neoplasma, 2005, 52(6): 450-455. https://pubmed.ncbi.nlm.nih.gov/16284688/.

9.Lephart ED, Andrus MB. Human skin gene expression: natural (trans) resveratrol versus five resveratrol analogs for dermal applications[J]. Exp Biol Med (Maywood), 2017, 242(15): 1482-1489. DOI: 10.1177/1535370217723628.

10.厉彦翔, 任禹思, 张苗苗, 等. 白藜芦醇苷的体外抗氧化活性研究[J]. 中国民族民间医药, 2019, 28(16): 24-26. [Li YX, Ren YS, Zhang MM, et al. Study on the antioxidant activity of polydatin[J]. Chinese Journal of Ethnomedicine and Ethnopharmacy, 2019, 28(16): 24-26.] DOI: 10.3969/j.issn.1007-8517.2019.16.zgmzmjyyzz201916008.

11.Farris P, Krutmann J, Li YH, et al. Resveratrol: a unique antioxidant offering a multi-mechanistic approach for treating aging skin[J]. J Drugs Dermatol, 2013, 12(12): 1389-1394. https://pubmed.ncbi.nlm.nih.gov/24301240/.

12.Chupradit S, Bokov D, Zamanian MY. Hepatoprotective and therapeutic effects of resveratrol: a focus on anti-inflammatory and anti-oxidative activities[J]. Fundam Clin Pharmacol, 2022, 36(3): 468-485. DOI: 10.1111/fcp.12746.

13.Varoni EM, Fabrizio LFA, Javad SR. Anticancer molecular mechanisms of resveratrol[J]. Front Nutr, 2016, 3: 8. DOI: 10.3389/fnut.2016.00008.

14.Ko JH, Sethi G, Um JY, et al. The role of resveratrol in cancer therapy[J]. Int J Mol Sci, 2017, 18(12): 2589. DOI: 10.3390/ijms18122589.

15.Patel KR, Brown VA, Jones DJL. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients[J]. 2010. 70(19): 7392-7399. DOI: 10.1158/0008-5472.CAN-10-2027.

16.Dos Santos MG, Schimith LE, André-Miral C, et al. Neuroprotective effects of resveratrol in vivo and in vitro experimental models of Parkinson's disease: a systematic review[J]. Neurotox Res, 2022, 40(1): 319-345. DOI: 10.1007/s12640-021-00450-x.

17.Bellaver B, Bobermin LD, Souza DG. Signaling mechanisms underlying the glioprotective effects of resveratrol against mitochondrial dysfunction[J]. Biochim Biophys Acta, 2016, 1862(9): 1827-1838. DOI: 10.1016/j.bbadis.

18.Chen J, Liu Q, Wang Y. Protective effects of resveratrol liposomes on mitochondria in substantia nigra cells of parkinsonized rats[J]. Ann Palliat Med, 2021, 10(3): 2458-2468. DOI: 10.21037/apm-19-426.

19.Azargoonjahromi A, Abutalebian F. Unraveling the therapeutic efficacy of resveratrol in Alzheimer's disease: an umbrella review of systematic evidence[J]. Nutr Metab (Lond), 2024, 21(1): 15. DOI: 10.1186/s12986-024-00792-1.

20.Cho S, Namkoong K, Shin M. Cardiovascular protective effects and clinical applications of resveratrol[J]. J Med Food, 2017, 20(4): 323-334. DOI: 10.1089/jmf.2016.3856.

21.Leticia F, César GJ. Effect of resveratrol on seric vascular endothelial growth factor concentrations during atherosclerosis[J]. Clin Investig Arterioscler, 2018, 30(5): 209-216. DOI: 10.1016/j.arteri.2018.04.003.

22.Ji WG, Sun J, Hu ZH. Resveratrol protects against atherosclerosis by downregulating the PI3K/AKT/mTOR signaling pathway in atherosclerosis model mice[J]. Exp Ther Med, 2022, 23(6): 414. DOI: 10.3892/etm.2022.11341.

23.Bonnefont-rousselot D. Resveratrol and cardiovascular diseases[J]. Nutrients, 2016, 8(5): 250. DOI: 10.3390/nu8050250.

24.Soltan F, Dahej ME, Yadegari M. Resveratrol confers protection against ischemia/reperfusion injury by increase of angiotensin (1-7) expression in a rat model of myocardial hypertrophy[J]. J Cardiovasc Pharmacol, 2021, 78(1): e55-e64. DOI: 10.1097/FJC.0000000000001035.

25.Schumacher B, Pothof J, Vijg J, et al. The central role of DNA damage in the ageing process[J]. Nature, 2021, 592(7856): 695-703. DOI: 10.1038/s41586-021-03307-7.

26.Shirley D, McHale C, Gomez G. Resveratrol preferentially inhibits IgE-dependent PGD2 biosynthesis but enhances TNF production from human skin mast cells[J]. Biochim Biophys Acta, 2016, 1860(4): 678-685. DOI: 10.1016/j.bbagen.2016.01.006.

27.Shin JW, Lee HS, Na JI, et al. Resveratrol inhibits particulate matter-induced inflammatory responses in human keratinocytes[J]. Int J Mol Sci, 2020, 21(10): 3446. DOI: 10.3390/ijms21103446.

28.Nisar MF, Liu T, Wang M, et al. Eriodictyol protects skin cells from UVA irradiation-induced photodamage by inhibition of the MAPK signaling pathway[J]. J Photochem Photobiol B, 2022, 226: 112350. DOI: 10.1016/j.jphotobiol. 2021.112350.

29.Cui B, Wang Y, Jin J, et al. Resveratrol treats UVB-induced photoaging by anti-MMP expression, through anti-inflammatory, antioxidant, and antiapoptotic properties, and treats photoaging by upregulating VEGF-B expression[J]. Oxid Med Cell Longev, 2022, 2022: 6037303. DOI: 10.1155/2022/6037303.

30.Adhami VM, Afaq F, Ahmad N. Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol[J]. Neoplasia, 2003, 5(1): 74-82. DOI: 10.1016/s1476-5586(03)80019-2.

31.Zheng Y, Yuan W, Liu H, et al. Injectable supramolecular gelatin hydrogel loading of resveratrol and histatin-1 for burn wound therapy[J]. Biomater Sci, 2020, 8(17): 4810-4820. DOI: 10.1039/d0bm00391c.

32.曾清华, 饶慧, 高洁生. 三甲氧基二苯乙烯对小鼠巨噬细胞产肿瘤坏死因子-α及细胞核因子-κB活性的作用研究[J]. 中国药业, 2014: 12-14. [ Zeng QH, Rao H, Gao JS. Effects of 3, 5, 4- trimethoxystilbene on TNF-& production and NF-кB activity in murine macrophages[J]. China Pharmaceuticals, 2014: 12-14.] DOI: CNKI:SUN:YYGZ.0.2014-14-007.

33.白根龙, 王姿月, 王萍, 等. 自噬在皮肤光损伤中的作用[J]. 重庆医学, 2021, 50(6): 1044-1047, 1052. [Bai GL, Wang ZY, Wang P, et al. Roles of autophagy in UV-induced skin damage[J]. Chongqing Medicine, 2021, 50(6): 1044-1047.] DOI: 10.3969/j.issn.1671-8348. 2021.06.030.

34.苏双, 阮云军, 马懿, 等. 白藜芦醇对过氧化氢诱导巨噬细胞炎性衰老的抑制作用及机制[J]. 山东医药, 2017, 57(37): 37-39. [Su S, Ruan YJ, Ma Y, et al. Resveratrol on hydrogen peroxide induced macrophage inflammatory inhibitory effect and mechanism of aging[J]. Shandong Medical Journal, 2017, 57(37): 37-39.] DOI: 10.3969/j.issn.1002-266X.2017.37.012.

35.Xia Y, Zhang H, Wu X, Xu Y, Tan Q. Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway[J]. Biogerontology, 2024, 25(4): 649-664. DOI: 10.1007/s10522-024-10099-6.

36.Zhou F, Huang X, Pan Y, et al. Resveratrol protects HaCaT cells from ultraviolet B-induced photoaging via upregulation of HSP27 and modulation of mitochondrial caspase-dependent apoptotic pathway[J]. Biochem Biophys Res Commun, 2018, 499(3): 662-668. DOI: 10.1016/j.bbrc.2018.03.207.

37.Baek J, Lee MG. Oxidative stress and antioxidant strategies in dermatology[J]. Redox Rep, 2016, 21(4): 164-169. DOI:10.1179/1351000215Y.0000000015.

38.Panich U, Sittithumcharee G, Rathviboon N, et al. Ultraviolet radiation-induced skin aging: the role of DNA damage and oxidative stress in epidermal stem cell damage mediated skin aging[J]. Stem Cells Int, 2016, 2016: 7370642. DOI: 10.1155/2016/7370642.

39.Chan CM, Huang CH, Li HJ, et al. Protective effects of resveratrol against UVA-induced damage in ARPE19 cells[J]. Int J Mol Sci, 2015, 16(3): 5789-5802. DOI: 10.3390/ijms16035789.

40.Liu Y, Chan F, Sun H, et al. Resveratrol protects human keratinocytes HaCaT cells from UVA-induced oxidative stress damage by downregulating Keap1 expression[J]. Eur J Pharmacol, 2011, 650(1): 130-137. DOI: 10.1016/j.ejphar.2010.10.009.

41.Kim J, Oh J, Averilla JN, et al. Grape peel extract and resveratrol inhibit wrinkle formation in mice model through activation of Nrf2/HO-1 signaling pathway[J]. J Food Sci, 2019, 84(6): 1600-1608. DOI: 10.1111/1750-3841.14643.

42.Stojanovie S, Sprinz H, Brede O. Efficiency and mechanism of the antioxidant action of transresveratrol and its analogues in the radical liposome oxidation[J]. Arch Biochem Biophys, 2001, 391(1): 79-89. DOI: 10.1006/abbi.2001.2388.

43.Fan GJ, Liu XD, Qian YP, et al. 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity[J]. Bioorg Med Chem, 2009, 17(6): 2360-2365. DOI: 10.1016/j.bmc.2009.02.014.

44.Ghazali AR, Rajab NF, Zainuddin MF, et al. Assessment of skin irritation and sensitisation effects by topical pterostilbene[J]. Bio Phar J, 2021, 14: 1917-1927. DOI: 10.13005/bpj/2290.

45.Sirerol JA, Feddi F, Mena S, et al. Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis[J]. Free Radic Biol Med, 2015, 85: 1-11. DOI: 10.1016/j.freeradbiomed.2015.03.027.

46.王春燕, 齐雪松, 佟鹏,等. 白皮杉醇和乙酰化白藜芦醇对小鼠辐射损伤的防护作用[J]. 中国生物制品学杂志, 2015, 28(4): 368-371. [Wang CY, Qi XS, SX, Tong P, et al. Protective effect of piceatannol and acetylated resveratrol on radiation damage in mice[J]. Chinese Journal of Biologicals, 2015: 368-371.] DOI: 10.13200/j.cnki.cjb.000849.

47.王春燕, 郝述霞, 佟鹏, 等. 白藜芦醇衍生物白皮杉醇和乙酰化白藜芦醇辐射防护作用研究[J]. 癌变·畸变·突变, 2012, 24(5): 345-348. [Wang CY, Hao SX, Tong P, et al. Radiation-protective effects of piceatannol and acetylated resveratrol[J]. Canceration, Aberration, Mutation. 2012, 24(5): 345-348.] DOI: 10.3969/j.issn.1004-616x.2012.05. 005.

48.Vashi NA, Wirya SA, Inyang M, et al. Facial hyperpigmentation in skin of color: special considerations and treatment[J]. Am J Clin Dermatol, 2017, 18(2): 215-230. DOI: 10.1007/s40257-016-0239-8.

49.Park J, Boo YC. Isolation of resveratrol from vitis viniferae caulis and its potent inhibition of human tyrosinase[J]. Evid Based Complement Alternat Med, 2013, 2013: 645257. DOI: 10.1155/2013/645257.

50.Lee TH, Seo JO, Baek SH, et al. Inhibitory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in Guinea pig skin[J]. Biomol Ther (Seoul), 2014, 22(1): 35-40. DOI: 10.4062/biomolther.2013.081.

51.Kim ES, Chang H, Choi H, et al. Autophagy induced by resveratrol suppresses α-MSH-induced melanogenesis[J]. Exp Dermatol, 2014, 23(3): 204-206. DOI: 10.1111/exd.12337.

52.贾丽丽, 李远宏, 吴严, 等. Res外涂美白功效及安全性的临床观察[J]. 中国美容医学, 2012, 21(9): 1340-1342. [Jia LL, Yuan HL, Wu Y, et al. Clinical observation the whitening efficacy and safety of resveratrol[J]. Chinese Journal of Aesthetic Medicine, 2012, 21(9): 1340-1342.] DOI: 10.3969/j.issn.1008-6455.2012.09.028.

53.Gutierrez D, Gaulding JV, Motta Beltran AF, et al. Photodermatoses in skin of colour[J]. J Eur Acad Dermatol Venereol, 2018, 32(11): 1879-1886. DOI: 10.1111/jdv.15115.

54.Sharma S, Chopra K, Kulkarni SK, et al. Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway[J]. Clin Exp Immunol, 2007, 147(1): 155-163. DOI: 10.1111/j.1365-2249.2006.03257.x.

55.Švajger U, Jeras M. Anti-inflammatory effects of resveratrol and its potential use in therapy of immune-mediated diseases[J]. Int Rev Immunol, 2012, 31(3): 202-222. DOI: 10.3109/08830185.2012.665108.

56.Farris P, Yatskayer M, Chen N, et al. Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin[J]. J Drugs Dermatol, 2014, 13(12): 1467-1472. https://pubmed.ncbi.nlm.nih.gov/25607790/.

57.Garbe C, Forsea AM, Amaral T, et al. Skin cancers are the most frequent cancers in fair-skinned populations, but we can prevent them[J]. Eur J Cancer, 2024, 204: 114074. DOI: 10.1016/j.ejca.2024.114074.

58.Harwood CA, Proby CM, Arron ST. Genomics of SCC: tumor formation, progression, and future therapeutic implications for high-risk cutaneous squamous cell carcinoma. in: schmults, c. (eds) High-Risk Cutaneous Squamous Cell Carcinoma[M]. Springer, Berlin, Heidelberg, 2016, 67-102.

59.Aziz MH, Reagan-Shaw S, Wu J, et. Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?[J]. FASEB J, 2005, 19(9): 1193-1195. DOI: 10.1096/fj.04-3582fje.

60.Zhang B, Najafi ML. Resveratrol inhibits skin squamous cell carcinoma proliferation, migration and invasion through up-regulating miR-126[J]. Cell Mol Biol (Noisy-le-grand), 2020, 66(5): 142-147. DOI: 10.14715/cmb/2020.66.5.25.

61.郝玉琴, 黄维星, 冯红霞, 等. 凋亡相关因子在Res抑制人皮肤鳞状细胞癌裸鼠移植瘤生长中的调节作用[J]. 中华医学杂志, 2013, 93(6): 464-468. [Hao YQ, Huang WX, Feng HX, et al. The inhibition of resveratrol to human skin squamous cell carcinoma A431 xenografts in nude mice[J]. National Medical Journal of China, 2013, 93(6): 464-468.] DOI: 10.3760/cma.j.issn.0376-2491.2013.06.018.

62.Kim KH, Back JH, Zhu Y, et al. Resveratrol targets transforming growth factor-β2 signaling to block UV-induced tumor progression[J]. J Invest Dermatol, 2011, 131(1): 195-202. DOI: 10.1038/jid.2010.250.

63.Liu J, Zheng R, Zhang Y, et al. The cross talk between cellular senescence and melanoma: from molecular pathogenesis to target therapies[J]. Cancers (Basel), 2023, 15(9): 2640. DOI: 10.3390/cancers15092640.

64.Craig S, Earnshaw CH, Virós A. Ultraviolet light and melanoma[J]. J Pathol, 2018, 244(5): 578-585. DOI: 10.1002/path.5039.

65.Zhao H, Han L, Jian Y, et al. Resveratrol induces apoptosis in human melanoma cell through negatively regulating Erk/PKM2/Bcl-2 axis[J]. Onco Targets Ther, 2018, 11: 8995-9006. DOI: 10.2147/OTT.S186247.

66.Yang S, Irani K, Heffron SE, et al. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor[J]. Mol Cancer Ther, 2005, 4(12): 1923-1935. DOI: 10.1158/1535-7163.MCT-05-0229.

67.孙正杨, 刘楠楠, 范学菲, 等. Res通过miR-512-3P/DUSP1轴抑制葡萄膜黑色素瘤细胞的自噬并促进细胞凋亡[J]. 中国药理学通报, 2024, 40(2): 292-298. [Sun ZY, Liu NN, Fan XF, et al, Resveratrol inhibits autophagy and promotes apoptosis in uveal melanoma cells via miR-512-3P/DUSP1 axis[J]. Chinese Pharmacological Bulletin, 2024, 40(2): 292-298.] DOI: 34.1086.R.20240129.1111.030.

68.张一楠. 白藜芦醇通过下调miR-31调节铁死亡治疗结肠癌的机制[D]. 太原: 山西医科大学, 2022. DOI: 10.27288/d.cnki.gsxyu.2022.000631.

69.Wu F, Cui L. Resveratrol suppresses melanoma by inhibting NF-κB/miR-221 and inducing TFG expression[J]. Arch Dermatol Res, 2017, 309(10): 823-831. DOI: 10.1007/s00403-017-1784-6.

70.余波, 刘伟, 胡敏琪, 等. 白皮杉醇抗恶性黑色素瘤的体内外实验研究[J]. 华西口腔医学杂志, 2021, 39(4): 413-418. [ Yu B, Liu W, Hu MQ, et, Effect of piceatannol against malignant melanoma in vivo and in vitro[J]. West China Journal of Stomatology, 2021, 39(4): 413-418.] DOI: 10.7518/hxkq.2021.04.006.

71.Eisenstein M. The skin microbiome[J]. Nature, 2020, 588(7838): S209. DOI: 10.1038/d41586-020-03523-7.

72.Howard B, Bascom CC, Hu P, et al. Aging-associated changes in the adult human skin microbiome and the host factors that affect skin microbiome composition[J] J Invest Dermatol, 2022, 142(7): 1934-1946. e21. DOI: 10.1016/j.jid.2021.11.029.

73.Belkaid Y, Tamoutounour S. The influence of skin microorganisms on cutaneous immunity[J]. Nat Rev Immunol, 2016, 16(6): 353-366. DOI: 10.1038/nri.2016.48.

74.Oh S, Kim SH, Ko Y, et al. Effect of bacteriocin produced by Lactococcus sp. HY 449 on skin-inflammatory bacteria[J] Food Chem Toxicol, 2006, 44(8): 1184-1190. DOI: 10.1016/j.fct.2005.08.008.

75.Garlet A, Andre-Frei V, Del Bene N, et al. Facial skin microbiome composition and functional shift with aging[J]. Microorganisms, 2024, 12(5): 1021. DOI: 10.3390/microorganisms12051021.

76.Zhang Z, Ran H, Hua Y, et al. Screening and evaluation of skin potential probiotic from high-altitude Tibetans to repair ultraviolet radiation damage[J]. Front Microbiol, 2023, 14: 1273902. DOI: 10.3389/fmicb.2023.1273902.

77.Chan MM. Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin[J] Biochem Pharmacol, 2002, 63(2): 99-104. DOI: 10.1016/s0006-2952(01)00886-3.

78.Vestergaard M, Ingmer H. Antibacterial and antifungal properties of resveratrol[J]. Int J Antimicrob Agents, 2019, 53(6): 716-723. DOI: 10.1016/j.ijantimicag.2019.02.015.

79.Mattio LM, Catinella G, Dallavalle S, et al. Stilbenoids: a natural arsenal against bacterial pathogens[J] Antibiotics (Basel), 2020, 9(6): 336. DOI: 10.3390/antibiotics9060336.

Popular papers
Last 6 months