Objective  To analyze the therapeutic effect of metronidazole chloramphenicol liniment combined with low-dose isotretinoin soft capsules on facial acne vulgaris.

Methods  The chinical data of patients with acne vulgaris who visited the outpatient department of Zhejiang Provincial Dermatology Hospital from June 2023 to June 2024 were retrospectively analyzed and divided into the control group and the study group according to different treatment strategies. The control group was treated with metronidazole chloramphenicol liniment, and on this basis, the study group was treated with low-dose isotretinoin soft capsules. The efficacy, drug resistance and treatment compliance, quality of life and adverse reactions in the two groups were compared.

Results  a total of 80 patients were included, with 40 in each group. The study group demonstrated a significantly higher total effective rate compared to the control group (P<0.05). There was no significant difference in drug resistance between the two groups during treatment (P﹥0.05). The excellent and good rate of treatment compliance in the study group was higher than that in the control group (P<0.05). After treatment, the scores of each dimension of the quality of life index for dermatology of the two groups decreased, however, the study group exhibited significantly lower scores in specific dimensions, including itching, pain, embarrassment, social and leisure activities, personal relationships, and treatment-related concerns (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P﹥0.05).

Conciusion  Metronidazole chloramphenicol liniment combined with low-dose isotretinoin soft capsules achieved better efficacy in the treatment of facial acne vulgaris, improved patient compliance and quality of life, and demonstrated good safety.

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