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Research progress on the analysis methods for phthalates plasticizers in pharmaceutical packaging materials and drugs

Published on Apr. 04, 2025Total Views: 46 times Total Downloads: 11 times Download Mobile

Author: JIA Feifei HAN Xiaoxu ZHAO Xia

Affiliation: National Institutes for Food and Drug Control, Beijing 100050, China

Keywords: Phthalates Plasticizer Drugs Pharmaceutical packaging materials Compatibility Safety Pretreatment Analytical methods

DOI: 10.12173/j.issn.2097-4922.202410056

Reference: JIA Feifei, HAN Xiaoxu, ZHAO Xia. Research progress on the analysis methods for phthalates plasticizers in pharmaceutical packaging materials and drugs[J]. Yaoxue QianYan Zazhi, 2025, 29(3): 531-540. DOI: 10.12173/j.issn.2097-4922.202410056.[Article in Chinese]

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Abstract

Phthalates (PAEs) compounds are plasticizers widely used in plastic products, and their toxicity and potential health hazards to humans have raised significant concern. This paper reviews the research progress on the chemical structure, toxicity, extraction or pretreatment methods, and analytical detection methods of PAEs, introduces pretreatment methods such as liquid-liquid extraction and solid-phase extraction, as well as analytical methods including gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS), discussing their principles, advantages and disadvantages. By systematically evaluating these methods, this paper aims to provide a reference for the future development of PAEs plasticizer detection methods and in-depth research on the compatibility of drugs and drug packaging materials..

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References

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