Objective  To investigate the influence of combination of Weifuchun capsule and conventional western medicine therapy on gastroscopy pathological scores and quality of life in patients with spleen-stomach deficiency type of chronic atrophic gastritis (CAG).

Methods  The clinical data of CAG patients admitted to Zhejiang Provincial Dermatology Hospital from January 2022 to December 2024 were retrospectively analyzed and divided into a control group (conventional western medicine treatment) and a combined group (Weifuchun capsule combined with conventional western medicine treatment) according to the difference treatment methods. The clinical efficacy, scores of various traditional Chinese medicine (TCM) syndromes, gastroscopy pathological scores (glandular atrophy, chronic inflammation, epithelial metaplasia, dysplasia), serum inflammatory factors [interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α)], quality of life [quality of life instruments for chronic diseases-chronic gastritis (QLICD-CG)] and safety were compared between the two groups.

Results  A total of 144 patients with CAG were included, including 70 cases in the control group and 74 cases in the combined group, and there was no statistically significant difference in the comparison of general information between the two groups (P>0.05). The total clinical effective rate was higher in the combined group than that in the control group [94.59% vs. 81.43%, P<0.05]. The TCM syndromes scores and pathological scores in the two groups were significantly improved compared with those before treatment (P<0.05), the levels of IL-1β and TNF-α were reduced compared to before treatment (P<0.05), and the scores and levels in the combined group were lower than those in the control group after treatment (P<0.05). The QLICD-CG scores were enhanced in both groups compared to before treatment (P<0.05), and the scores in the combined group after treatment were higher in comparison with the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between two groups (P>0.05).

Conclusion   The combination of conventional western medicine and Weifuchun capsule can effectively improve the clinical symptoms, the gastric mucosal pathological condition and inflammatory status in CAR patients.

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