Objective  To study the efficacy of Dahuang Zhechong tablets on patients with atrophic gastritis with intestinal metaplasia (CAG-IM).

Methods  CAG-IM patients with stomach collateral blood stasis syndrome admitted to Huzhou Hospital of Traditional Chinese Medicine of Zhejiang Chinese Medicine University from April 2023 to September 2024 were enrolled and divided into the control group (Weifuchun capsules) and the test group (Weifuchun capsules combined with Dahuang Zhechong tablets), with a treatment duration of 24 weeks. The TCM syndrome scores, histopathological scores, pepsinogen I (PG I), gastrin-17 (G-17), interferon-γ (IFN-γ), interleukin-6 (IL- 6) and positive rates of vascular endothelial growth factor (VEGF), caudal type homeobox transcription factor-2 (CDX2) protein, and p53 protein were compared before and after treatment.

Results A total of 100 patients were included, 50 in the control group and 50 in the experimental group. After 24 weeks of treatment, the TCM syndrome scores, histopathological scores, levels of IFN-γ and IL-6 and positive rates of VEGF, CDX2 protein and p53 protein in both groups were significantly decreased, with lower values in the test group compared to the control group (P<0.05). The levels of PG I and G-17 in both groups were significantly increased, with higher values in the test group than in the control group (P<0.05). The incidence of adverse reactions in the test group was higher than that in the control group, but the difference was not statistically significant (P>0.05).

Conclusion  Weifuchun capsules combined with Dahuang Zhechong tablets may benefit from relieving clinical symptoms and inflammation level as well as improving pathological tissue performance and gastric digestive function in patients with CAG-IM of Stomach Collateral Blood Stasis Syndrome..

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