Optimization of fresh-cutting processing for Cistanche deserticola using AHP-CRITIC method combined with Box-Behnken design-response surface method

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Author: LIU Zhaofu ¹ XU Lifang ^2, ^3, ⁴ HU Xiaoli ² LI Junxian ² DENG Kun ²  YE Xide ²  ZHONG Lingyun ²

Affiliation: 1. National Engineering Research Center for Manufacturing Technology of Traditional Chinese Medicine Solid Preparations, Jiangxi University of Chinese Medicine, Nanchang 330004, China 2. School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China 3. Department of Pharmacy, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, China 4. National Traditional Chinese Medicine Processing Technology Inheritance Base, Nanchang 330006, China

Keywords: Cistanche deserticola Fresh-cutting Analytic hierarchy process-criteria importance through intercriteria correlation method Box-Behnken design-response surface method Echinacoside Verbascoside

DOI: 10.12173/j.issn.2097-4922.202604012

Reference: LIU Zhaofu, XU Lifang, HU Xiaoli, LI Junxian, DENG Kun, YE Xide, ZHONG Lingyun.Optimization of fresh-cutting processing for Cistanche deserticola using AHP-CRITIC method combined with Box-Behnken design-response surface method[J]. Yaoxue QianYan Zazhi, 2026, 30(5): 759 - 766. DOI: 10.12173/j.issn.2097-4922.202604012[Article in Chinese]  Copied

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Abstract

Objective To optimize the fresh-cutting processing of Cistanche deserticola and determine the optimal process parameters.

Methods The contents of echinacoside and verbascoside in Cistanche deserticola processed products were determined by HPLC. The content of alcohol-soluble extract was determined according to the Chinese Pharmacopoeia (2025 edition). Using the contents of echinacoside, verbascoside and alcohol-soluble extract as evaluation indicators, a comprehensive weighting method combining analytic hierarchy process (AHP) and criteria importance through intercriteria correlation (CRITIC) method was employed to calculate the composite score. The slice thickness, drying temperature, and drying time were selected as the investigated factors, and single-factor tests and the Box-Behnken design-response surface method were used to optimize the fresh-cutting processing parameters of Cistanche deserticola.

Results The optimal processing parameters were as follows: slice thickness of 3 mm, drying temperature of 60°C, and drying time of 20 h.

Conclusion The optimal processing technology for fresh-cutting of Cistanche deserticola selected in this study is stable, reliable and scientifically sound, and can provide data support for the in-depth research and industrial production of Cistanche deserticola.

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References

1. 中国药典2025年版. 一部[S]. 2025: 144-145.

2. 佚名. 尚志钧, 校注. 神农本草经[M]. 北京: 学苑出版社, 2008: 166-167.

3. 王利, 松伟, 刘小雪, 等. 肉苁蓉生物活性成分及功效的研究进展[J]. 食品科技, 2023, 48(2): 208-214. [Wang L, Song W, Liu XX, et al. Research progress on bioactive components and efficacy of Cistanche deserticola[J]. Food Science and Technology, 2023, 48(2): 208-214.].https://d.wanfangdata.com.cn/periodical/CiBQZXJpb2RpY2FsQ0hJU29scjkyMDI2MDYwMjE2MjUxORINc3BrajIwMjMwMjAzMRoIZ3VmYTI5ZXc%3D.

4. 毕龙成, 钟平胜, 田义明, 等. 荒漠肉苁蓉活性成分的药理作用及质量影响因素[J]. 食品科学, 2026, 47(2): 307-321. [Bi LC, Zhong PS, Tian YM, et al. Research progress on Cistanches deserticola Y.C.Ma as a medicinal and edible plant: pharmacological effects of active components and factors influencing its quality[J]. Food Science, 2026,47(2): 307-321.] DOI: 10.7506/spkx1002-6630-20250705-031.

5. 东汉·华佗, 著. 古求知, 校注. 华氏中藏经[M]. 北京: 中国医药科技出版社, 2011: 63.

6. 刘宋·雷敩, 著. 王兴法, 辑校. 雷公炮炙论: 辑佚本[M]. 上海:上海中医学院出版社, 1986: 22.

7. 清·严西亭, 著. 得配本草[M]. 上海: 上海科学技术出版社, 1958:9.

8. 陈昌懋, 尕藏扎西, 王劼, 等. 肉苁蓉活性成分及药理作用机制研究进展[J]. 中草药, 2025, 56(12): 4464-4477. [Chen CG, Gazang ZX, Wang J, et al. Research progress on active components and pharmacological mechanisms of Cistanches Herba[J]. Chinese Traditional and Herbal Drugs, 2025, 56(12): 4464-4477.].https://d.wanfangdata.com.cn/periodical/CiBQZXJpb2RpY2FsQ0hJU29scjky MDI2MDYwMjE2MjUxORIMemN5MjAyNTEyMDI4GghxbW9ucG04cQ%3D%3D.

9. 张超, 华悦, 廉婧, 等. 肉苁蓉炮制过程中苯乙醇苷类成分含量变化规律研究[J]. 中国中医药信息杂志, 2022, 29(4): 92-97. [Zhang C, Hua Y, Lian J, et al. Study on variation laws of content of phenylethanol glycosides in Cistanches Herba during processing[J].Chinese Journal of Information on Traditional Chinese Medicine, 2022, 29(4): 92-97.] DOI: 10.19879/j.cnki.1005-5304.202108567.

10. 陈百泉, 刘瑜新, 康文艺. 人工栽培肉苁蓉保肝和抗氧化活性研究[J]. 精细化工,2010, 27(4): 342-345. [Chen BQ, Liu YX, Kang WY. Hepatoprotective effect and antioxidant activity of cultivate Cistanche deserticola Y.C.Ma[J]. Fine Chemicals, 2010, 27(4): 342-345.] DOI:10.13550/j.jxhg.2010.04.026.

11. 王淑凡, 罗福祥, 闫明, 等. 管花肉苁蓉趁鲜蒸制工艺优化[J/OL]. 中成药, 1-6(2025-06-27). [Wang SF, Luo FX, Yan M, et al. Optimization of fresh steaming process of Cistanche tubulosa[J/OL]. Chinese Traditional Patent Medicine, 1-6(2025-06-27).] https://kns.cnki.net/kcms2/article/abstract?v=t_h3i5Pmq2w-nHUoaEJC1Rj L0Ydi09hHgZ7Y8_Kcn9pmnsu_atFSeSnKSGONxXSfPabYDfVdRnhItEWl2PZFaCf0SyAXfaMYq2CwpLdYXhUFvsSV_EPY6x4OZV cfMqYM93Nj-e_hdgToJNKNiJBvklmSs_6X5ETH27lpau5-Ztwmev i1zEYbvg==&uniplatform=NZKPT&language=CHS.

12. 孙悦, 包旭宏, 刘文伟, 等. 松果菊苷药理作用及机制的研究进展[J]. 天然产物研究与开发, 2024, 36(8): 1445-1455. [Sun Y, Bao XH, Liu WW, et al. Research progress on the pharmacological action and mechanism of echinacoside[J]. Natural Product Research and Development, 2024, 36(8): 1445-1455.].https://d.wanfangdata.com.cn/periodical/CiBQZXJpb2RpY2FsQ0hJU29scjkyMDI2MDYwMjE 2MjUxORISdHJjd3lqeWtmMjAyNDA4MDE4Ggh3dTU3MmhyYQ%3D%3D.

13. 黄文静, 谢兴亮, 盛艳梅. 毛蕊花糖苷药理作用及其制剂研发进展[J]. 中草药, 2024, 55(23): 8256-8268. [Huang WJ, Xie XL, Sheng YM. Pharmacological effects and preparation development progress of verbascoside[J]. Chinese Traditional and Herbal Drugs, 2024, 55(23): 8256-8268.].https://d.wanfangdata.com.cn/periodical/CiBQZXJpb2RpY2FsQ0hJU29scjkyMDI2MDYwMjE2MjUxORIMe mN5MjAyNDIzMDMwGghwZW1vNXNraQ%3D%3D.

14. 徐万爱, 于欢, 林丽娜, 等. 基于AHP-CRITIC熵权法结合正交试验设计优选肉苁蓉的酒浸焙炮制工艺及质量标准研究[J]. 中药材, 2025, 48(2): 340-347. [Xu WA, Yu H, Lin LN, et al. Based on AHP-CRITIC entropy weight method combined with orthogonal test design, the processing technology and quality standard of Cistanche deserticola were optimized[J]. Journal of Chinese Medicinal Materials, 2025, 48(2): 340-347.] DOI: 10.13863/j.issn1001-4454.2025.02.013.

15. 康悦, 陈凯文, 邓晨陽, 等. 基于AHP-CRITIC结合Box-Behnken设计-响应面法优选天麻酒制工艺[J]. 中药材, 2026, (4): 903-909. [Kang Y, Chen KW, Deng CY,et al.Based on AHP-CRITIC combined with Box-Behnken design-response surface method to optimize the wine processing technology of Gastrodia elata[J]. Journal of Chinese Medicinal Materials, 2026, (4): 903-909.] DOI: 10.13863/j.issn1001-4454.2026.04.012.

16. 方逸倩, 史培, 张治峰, 等. 药食同源中药肉苁蓉中苯乙醇苷的研究进展[J]. 食品工业, 2024, 45(11): 281-285. [Fang YQ, Shi P, Zhang ZF, et al. Research progress of phenylethanolglycoside in Cistache deserticola in traditional Chinese medicine-food homology[J]. The Food Industry, 2024, 45(11): 281-285.].https://kns.cnki.net/kcms2/article/abstract?v=7jvqSXIa2LVpHQa5pW8ZMrm8g9ozmF5aQDVL I02UxTr0ZfjxLUUfB93eLwZ595U1VIiSnKSA4jnbQC4pmsPBYQNqsBK7PDNRn33Gg0ghPCkKUogfRtsS5frMTsOjpdkOkFeunWqYSzIcxBRkNIyankl7Qdgix7NG38AaXwAI5QcPG-H-5_ei0w==&un iplatform=NZKPT&language=CHS.

17. 叶喜德, 卜俊文, 邵明国, 等. AHP-熵权法结合Box-Behnken设计-响应面法优选建昌帮酒润蜜糠炒白芍炮制工艺[J]. 药学前沿, 2026, 30(2): 201-210. [Ye XD, Bu JW, Shao MG, et al. AHP-entropy weight method combined with Box-Behnken design-response surface method optimized processing technology of Jianchangbang wine moistened honey bran fried Paeoniae Radix Alba[J]. Frontiers in Pharmaceutical Sciences , 2026, 30(2): 201-210.] DOI: 10.12173/j.issn.2097-4922.202509049.

18. 鲍文杰, 钟凌云, 伍文华, 等. 中药趁鲜切制机制——传统智慧与现代技术融合探析[J]. 中国实验方剂学杂志, 2026, 32(7): 282-290. [Bao WJ, Zhong LY, Wu WH, et al. Mechanism of fresh cutting of traditional Chinese medicine: discussion on integration of traditional wisdom and modern technology[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2026, 32(7): 282-290.] DOI: 10.13422/j.cnki.syfjx.20252161.

19. 姜勇, 鲍忠, 孙永强, 等. 肉苁蓉片的炮制工艺研究[J]. 中国药学杂志, 2011, 46(14): 1074-1076. [Jiang Y, Bao Z, Sun YQ, et al. Study on processing method of Cistanches Herba decoction pieces[J]. Chinese Pharmaceutical Journal, 2011, 46(14): 1074-1076.].https://www.cnki.com.cn/Article/CJFDTotal-ZGYX201114010.htm.