Objective  To investigate the effects of insulin degludec/insulin aspart (IDegAsp) combined with an integrated diet management model (IDMM) on blood glucose control, lipid metabolism, health behaviors, self-management ability, and quality of life in patients with type 2 diabetes mellitus (T2DM).

Methods  Clinical data of T2DM patients diagnosed and treated in the Endocrinology Department of Wenzhou Traditional Chinese Medicine Hospital from January 2023 to June 2024 were retrospectively collected. Based on whether IDMM was adopted, the patients were divided into an IDegAsp group and an IDegAsp combined with IDMM group (IDegAsp-IDMM group). After 12 weeks of intervention, the blood glucose control indicators, the blood lipid metabolism indicators, health promoting lifestyle profile-II (HPLP-II) score, summary of diabetes self-care activities scale (SDSCA) score, and adjusted diabetes quality of life scale (A-DQOL) score of the two groups of patients were compared.

Results  A total of T2DM 107 patients were included, including 57 in the IDegAsp group and 50 in the IDegAsp-IDMM group. After intervention, in terms of blood glucose control indicators, fasting C-peptide, 2-hour post-meal C-peptide, fasting blood glucose, 2-hour post-meal blood glucose, and glycated hemoglobin in the IDegAsp-IDMM group were significantly lower than those in the IDegAsp group (P < 0.05). In terms of lipid metabolism indicators, HDL in T2DM patients in the IDegAsp-IDMM group was significantly higher than that in the IDegAsp group, while TG, LDL, and TC were significantly lower than those in the IDegAsp group (P < 0.05). In terms of scale scores, the HPLP-II scores and SDSCA scores of T2DM patients in the IDegAsp-IDMM group were significantly higher than those in the IDegAsp group, while the A-DQOL score was significantly lower than that in the IDegAsp group (P < 0.05).

Conclusion  The overall efficacy of IDegAsp-IDMM is better than that of IDegAsp alone, and it can improve glycolipid metabolism, health behaviors, self - management ability, and quality of life in T2DM patients.

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