Research progress of factors influencing the efficacy of nonsteroidal anti-inflammatory drugs

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Author: Gulinigeer·AINIWAER ^1, ² XIE Han ³ CHEN Xinyi ⁴ MA Xudong ^1, ²  GE Weihong ¹  YU Feng ²

Affiliation: 1. Department of Pharmacy, China Pharmaceutical University Nanjing Drum Tower Hospital, Nanjing 210008, China 2. School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China 3. Department of Pharmacy, Nanjing Drum Tower Hospital Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China 4. Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210009, China

Keywords: Non-steroidal anti-inflammatory drugs Differences in efficacy Drug metabolizing enzymes CYP2C9 Cyclooxygenase Intestinal microbiota Osteoarthritis Rheumatoid arthritis Gene polymorphism

DOI: 10.12173/j.issn.1008-049X.202402133

Reference: Gulinigeer·AINIWAER, XIE Han, CHEN Xinyi, MA Xudong, GE Weihong ,YU Feng.Research progress of factors influencing the efficacy of nonsteroidal anti-inflammatory drugs[J].Zhongguo Yaoshi Zazhi,2024, 27(5):885-891.DOI: 10.12173/j.issn.1008-049X.202402133.[Article in Chinese]  Copied

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Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat osteoarthritis, rheumatoid arthritis, and acute and chronic painful diseases. Significant interindividual heterogeneity in the efficacy of NSAIDs has been found in patients, which can lead to treatment failure or life-threatening adverse drug reactions. This review will discuss the causes of the variability in the efficacy of NSAIDs in terms of CYP2C9 enzyme gene polymorphism, cyclooxygenase enzyme gene polymorphism, and differences in the intestinal microbiota, to provide a reference for the development of individualized dosing regimens for NSAIDs.

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