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Effect of propofol combined with etomidate on hemodynamics and stress response during weight loss surgery

Published on Nov. 08, 2024Total Views: 224 times Total Downloads: 13 times Download Mobile

Author: JIAO Hongwei 1 FENG Xiaoyue 2 MA Peng 3 DUAN Yinglei 1 LYU Zhigan 1

Affiliation: 1. Department of Anesthesiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan 030032, China 2. Department of Pain, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan 030032, China 3. Department of Thyroid and Bariatric Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan 030032, China

Keywords: Weight loss surgery Propofol Etomidate Hemodynamics Stress response Cognitive impairment Adverse reactions

DOI: 10.12173/j.issn.2097-4922.202408003

Reference: JIAO Hongwei, FENG Xiaoyue, MA Peng, DUAN Yinglei, LYU Zhigan.Effect of propofol combined with etomidate on hemodynamics and stress response during weight loss surgery[J].Yaoxue QianYan Zazhi,2024, 28(2):206-212.DOI: 10.12173/j.issn.2097-4922.202408003.[Article in Chinese]

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Abstract

Objective  To observe the value of propofol combined with etomidate in bariatric surgery based on hemodynamics and stress response.

Methods  Patients admitted to Shanxi Bethune Hospital who underwent bariatric surgery from January 2020 to January 2021 were retrospectively selected and divided into an experimental group (propofol combined with etomidate) and a control group (propofol) according to the intraoperative anesthesia regimen. The patient's surgical time, awakening time, extubation time, hemodynamic indicators [heart rate (HR), mean arterial pressure (MAP), blood oxygen saturation (SpO2)], stress indicators [adrenocorticotropic hormone (ACTH), adrenaline (ADR), cortisol (COR)], Mini Mental State Examination (MMSE) score, and adverse reactions were recorded.

Results  A total of 80 patients were included in the study, among which 47 cases were in the experimental group, and 33 cases were in the control group. There was no statistically significant difference in operation time, awakening time and extubation time between the two groups (P>0.05). Immediately after intubation, HR and MAP of the experimental group were lower than those of the control group, and SpO2 was higher than that of the control group (P<0.05). Serum ACTH, ADR and COR levels in the experimental group were higher than those in the control group immediately after intubation and 5 min after extubation (P<0.05). The MMSE score of the experimental group 10 min after awakening was higher than that of the control group (P<0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05).

Conclusion The use of propofol combined with etomidate in weight loss surgery can reduce hemodynamic fluctuations, alleviate cognitive impairment, alleviate stress reactions, and does not significantly increase anesthesia adverse reactions, which is with good safety.

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References

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