Objective  To analyze the postoperative effect of probiotics combined with Peitu Shengjin moxibustion and cupping on adenomatous colorectal polyps (ACP).

Methods   Patients with ACP diagnosed and treated in Zhejiang Provincial Hospital of Traditional Chinese Medicine from August 2021 to May 2022 were recruited as study subjects, and were divided into control group(probiotics) and test group (probiotics combined with Peitu Shengjin moxibustion and cupping). The main outcome measure of this study was the 1-year recurrence rate of ACP. The secondary outcome measures were the treatment efficiency and the traditional Chinese medicine (TCM) syndrome scores at 4 weeks and 1 year after ACP surgery.

Results  The study finally included 199 patients, with 100 in the control group and 99 in the test group. The 1-year postoperative treatment efficiency of the test group was higher than that of the control group (P=0.012); the recurrence rate was lower than that of the control group (P<0.05). There was no statistically significant difference in the comparison of polyp size and number between the two groups of patients with recurrence (P>0.05). Before treatment, there was no statistically significant difference between the two groups in the comparison of stool habit score, stool nature score, blood in stool score, stool frequency score, abdominal pain score and total score (P>0.05). The stool habit score, stool nature score, stool blood score, stool frequency score, abdominal pain score and total score of the patients in both groups were significantly lower than those of the preoperative period at 4 weeks and 1 year after the operation (P<0.05). Stool habit score, stool nature score, stool blood score, stool frequency score, abdominal pain score and total score were lower in the test group than in the control group at 4 weeks and 1 year postoperatively (P<0.05).

Conclusion  Probiotics combined with Peitu Shengjin moxibustion and cupping can effectively improve the TCM syndrome scores after ACP surgery and reduce the recurrence rate of ACP.

1.王晨, 闫雪洁, 考延磊. 闫雪洁从肝脾不调论治预防腺瘤性大肠息肉术后复发的经验[J]. 中国中医药现代远程教育, 2023, 21(14): 69-71. [Wang C, Yan XJ, Kao  YL. Yan Xuejie's experience in treating and preventing the postoperative recurrence of adenomatous colorectal polyps from the perspective of disharmony between the liver and spleen[J]. Chinese Medicine Modern Distance Education of China, 2023, 21(14): 69-71.] DOI: 10.3969/j.issn. 1672-2779.2023.14.026.

2.朱冉飞, 赵壮壮. 大肠息肉患者发病特点及与中医证型的相关性分析[J]. 中医药导报, 2023, 29(11): 109-112. [Zhu RF, Zhao ZZ. Analysis of the Incidence characteristics of patients with colorectal polyps and their correlation with traditional Chinese medicine syndromes[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacology, 2023, 29(11): 109-112.] DOI: 10.13862/j.cn43-1446/r.2023.11.020.

3.许亚培, 杨铸锋, 龙润. 中医中药治疗大肠息肉的研究进展[J]. 中国医药科学, 2023, 13(21): 34-36, 98. [Xu YP, Yang ZF, Long R. Research progress of traditional Chinese medicine in the treatment of colorectal polyps[J]. China Medicine and Pharmacy, 2023, 13(21): 34-36, 98.] DOI: 10.20116/j.issn2095-0616.2023.21.08.

4.卢小青, 傅大霖, 王宗明. 中医药治疗大肠息肉的研究进展[J]. 中国当代医药, 2023, 30(1): 25-30. [Lu XQ, Fu DL, Wang ZM. Research progress of traditional Chinese medicine in the treatment of colorectal polyps[J]. China Modern Medicine, 2023, 30(1): 25-30.] DOI: 10.3969/j.issn.1674-4721.2023.01.007.

5.Chen YX, Gao QY, Zou TH, et al. Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study[J]. Lancet Gastroenterol Hepatol, 2020, 5(3): 267-275. DOI: 10.1016/S2468-1253(19)30409-1.

6.张博彤, 李明煜, 薛源, 等. 益生菌改善老年人肠道菌群失衡相关疾病的研究进展[J]. 食品与发酵工业, 2024, 50(15): 350-358. [Zhang BT, Li MY, Xue Y, et al. Progress of probiotics in improving intestinal flora imbalance-related diseases in the elderly[J]. Food and Fermentation Industry, 2024, 50(15): 350-358] DOI: 10.13995/j.cnki.11-1802/ts.039243.

7.兰强芳, 周燕, 邵伟. 益生菌联合复方聚乙二醇散+乳果糖在慢性便秘患者肠道准备中的应用价值[J]. 中国药师, 2024, 27(3): 463-469. [Lan QF, Zhou Y, Shao W. Value of probiotics in combination with compound PEG powder+lactulose in intestinal preparation in patients with chronic constipation[J]. China Pharmacist 2024, 27(3): 463-469.] DOI: 10.12173/j.issn. 1008-049X.202401133.

8.苏连明, 刘志威, 朱雯. 内镜下高频电凝电切术结合益生菌治疗对结肠息肉患者肠道菌群、并发症及预后的影响[J]. 医学理论与实践, 2022, 35(7): 1134-1136. [Su LM, Liu ZW, Zhu W. Effect of endoscopic high-frequency electrocoagulation resection combined with probiotic therapy on intestinal microflora, complications and prognosis in patients with colon polyps[J]. Medical Theory and Practice, 2022, 35(7): 1134-1136.] DOI: 10.19381/j.issn.1001-7585.2022.07.021.

9.徐升, 吴敏华, 徐芳, 等. 平息汤保留灌肠联合益生菌对腺瘤性肠息肉术后的影响[J]. 新中医, 2022, 54(1): 104-107. [Xu S, Wu MH, Xu F, et al. To ell the effect of preserved enema combined with probiotics on adenomatous intestinal polyp[J]. New Traditional Chinese Medicine, 2022, 54(1): 104-107.] DOI: 10.13457/j.cnki.jncm.2022.01.023.

10.叶凡, 李琢, 黄兴, 等. 益生菌辅助化疗对晚期大肠癌患者的临床疗效和安全性评价[J]. 中国药师, 2024, 27(2): 295-301. [Ye F, Li Z, Huang X, et al. Evaluation of the clinical efficacy and safety of probiotics-assisted chemotherapy in patients with advanced colorectal cancer[J]. China Pharmacist, 2024, 27(2): 295-301.] DOI: 10.12173/j.issn.1008-049X.202401114.

11.Hang YL, Zhang ZS, Wu BP, et al. Early diagnosis for colorectal cancer in China[J]. World J Gastroenterol, 2002, 8(1): 21-25. DOI: 10.3748/wjg.v8.i1.21.

12.阿布都萨拉木·阿布拉, 热依拉·加帕尔, 刘雪芳, 等. 结直肠扁平息肉内镜黏膜切除术后的病理学分析[J]. 中华消化外科杂志, 2018, 17(2): 173-176. [Abudusalamu Abula, Reyila Gapal, Liu XF, et al. Pathological analysis after endoscopic mucosal resection of colorectal flat polyps[J]. Chinese Journal of Digestive Surgery, 2018, 17(2): 173-176.] DOI: 10.3760/cma.j.issn.1673-9752.2018.02.010.

13.陈绮婷, 谢伟昌, 李京伟, 等. 健脾理肠汤预防腺瘤性大肠息肉术后复发临床观察[J]. 广州中医药大学学报, 2020, 37(1): 30-35. [Chen QT, Xie WC, Li JW, et al. Clinical observation on the prevention of postoperative recurrence of adenomatous colorectal polyps by Jianpi Lichang decoction[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2020, 37(1): 30-35.] DOI: 10.13359/j.cnki.gzxbtcm.2020.01.006.

14.王吉利. 中药五倍子乌梅汤保留灌肠预防内镜下肠息肉摘除术后复发的效果研究[J]. 实用临床医药杂志, 2019, 23(23): 55-57. [Wang JL. Study on the effect of retention enema with Chinese medicine Wuweizi Wumei decoction in preventing the recurrence after endoscopic removal of intestinal polyps[J]. Journal of Practical Clinical Medicine, 2019, 23(23): 55-57.] DOI: 10.7619/jcmp.201923016.

15.孟曼, 张涛, 苏晓兰, 等. 穴位贴敷改善大肠息肉切除术后腹部不适症状的临床疗效观察[J].中国中西医结合消化杂志, 2022, 30(1): 60-64. [Meng M, Zhang T, Su XL, et al. Clinical observation on the therapeutic effect of acupoint application in improving abdominal discomfort symptoms after resection of colorectal polyps[J]. Chinese Journal of Integrated Traditional and Western Digestion, 2022, 30(1): 60-64.] DOI: 10.3969/j.issn.1671-038X.2022.01.13.

16.戴美兰, 覃健. 雷火灸预防腺瘤性大肠息肉内镜治疗后复发的效果观察[J]. 护理研究: 中旬版, 2016, 30(2): 224-225. [Dai ML, Qin J. Observation on the effect of thunder-fire moxibustion in preventing the recurrence of adenomatous colorectal polyps after endoscopic treatment[J]. Nursing Research: Mid-Journal, 2016, 30(2): 224-225.] DOI: 10.3969/j.issn.1009-6493.2016.02.039.

17.袁军, 陈畅, 康国辉, 等. 陶瓷灸罐疗法对体虚易感患者免疫功能的影响[J]. 中华中医药杂志, 2020, 35(4): 2129-2133. [Yuan J, Chen C, Kang GH, et al. Effect of ceramic moxibustion pot therapy on the immune function of patients susceptible to body deficiency[J]. Chinese Journal of Traditional Chinese Medicine, 2020, 35(4): 2129-2133.] https://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_zgyyxb202004136&dbid=WF_QK.

18.黄缨媛, 黄艳娟, 曾雪蓉, 等. 灸法治疗早发性卵巢功能不全作用机制研究进展[J]. 河北中医, 2024, 46(2): 337-341, 346. [Huang YY, Huang YJ, Zeng XR, et al. Progress on moxibustion treatment mechanism of early onset ovarian insufficiency[J]. Hebei Journal of Traditional Chinese Medicine, 2024, 46(2): 337-341, 346.] DOI: 10.3969/j.issn.1002-2619.2024.02.037.

19.吴焕淦, 朱璐, 刘慧荣, 等. 灸法治疗胃肠疾病的效应机制研究[J]. 世界中医药, 2022, 17(3): 287-294, 303. [Wu  HG, Zhu L, Liu HR, et al. Study on the effect mechanism of moxibustion in the treatment of gastrointestinal diseases[J]. World Traditional Chinese Medicine, 2022, 17(3): 287-294, 303.] DOI: 10.3969/j.issn.1673-7202.2022.03.001.

20.张凤敏, 卢晓敏, 胡庆昌. 培土生金法预防大肠息肉复发的临床研究[J]. 中国中西医结合消化杂志, 2015, 23(5): 342-344. [Zhang FM, Lu XM, Hu QC. Clinical study on the prevention of the recurrence of colorectal polyps by the method of strengthening the earth to generate metal[J]. Chinese Journal of Integrated Traditional and Western Digestion, 2015, 23(5): 342-344.] DOI: 10.3969/j.issn.1671-038X.2015.05.10.

21.张凤敏, 黄广文, 胡庆昌, 等. 培土生金法防治腺瘤性大肠息肉的临床研究[J]. 广州中医药大学学报, 2017, 34(5): 650-654. [Zhang FM, Huang GW, Hu  QC, et al. Clinical study on the prevention and treatment of adenomatous colorectal polyps by the method of strengthening the earth to generate metal[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2017, 34(5): 650-654.] DOI: 10.13359/j.cnki.gzxbtcm. 2017.05.007.