Objective  To explore the current status and research hotspots of Sophorae Tonkinensis (Shandougen), and to provide valuable reference for its future development trend.

Methods  China National Knowledge Infrastructure (CNKI), WanFang and VIP databases were retrieved for the literature on the toxicity of Sophorae tonkinensis from the day of inception to December 2024. CiteSpace software was applied to analyze the institutional cooperation network, keyword clustering and keyword emergence. VOSviewer software was applied to analyze the author co-occurrence map and keyword co-occurrence map.

Results  A total of 483 studies were collected after screening. The author with the most publications was Sun Rong. The institution with the largest number of literatures is Shandong University of Traditional Chinese Medicine (TCM), and the connections between research teams and various institutions were not close, so it is necessary to strengthen the exchanges and cooperation. Keyword co-occurrence, clustering, and emergent analysis showed that the research hotspots mainly focused on toxicology, toxicity test, toxic components, molecular mechanism, compatible attenuated application, and identification of TCM.

Conclusion  Currently, the research on Sophorae tonkinensis is still in an upward stage. In the future, more attention should be paid to rational drug use, metabolomics, and anti-tumor effects. There is a lack of large-scale collaboration between teams and regions, and sustainability research should be strengthened.

1.袁丛军, 令狐克念, 王浩东, 等. 山豆根主要活性成分含量及影响因素研究进展[J]. 中国野生植物资源, 2023, 42(10): 84-89. [Yuan CJ, Linghu KN, Wang HD, et al. Research progress on active components and their influencing factors of Sophora tonkinensis[J]. Chinese Wild Plant Resources, 2023, 42(10): 84-89.] DOI: 10.3969/j.issn.1006-9690.2023.10.015.

2.邹俐, 赵焕君, 李娜, 等. 山豆根的本草考证及毒性分析[J]. 现代中医药, 2021, 41(5): 19-23. [Zou L, Zhao HJ, Li N, et al. Herbal textual research and toxicity analysis of Radix Sophorae[J]. Modern Chinese Medicine, 2021, 41(5): 19-23.] DOI: 10.13424/j.cnki.mtcm.2021.05.004.

3.陆春莲, 梁洁, 孙正伊, 等. 山豆根的质量控制现状及质量标志物预测分析[J]. 中华中医药学刊, 2024, 42(5): 103-107. [Lu CI, Liang J, Sun ZY, et al. Quality control status and predictive analysis of quality markers of Shandougen (Sophorae Tonkinensis Radix et Rhizoma)[J]. Chinese Archives of Traditional Chinese Medicine, 2024, 42(5): 103-107.] DOI: 10.13193/j.issn.1673-7717.2024.05.022.

4.陈影, 陈两绵, 仝燕, 等. 山豆根药理毒理研究进展[J]. 中国中药杂志, 2017, 42(13): 2439-2442. [Chen Y, Chen LM, Tong Y, et al. Pharmacological effect and toxicology of Sophorae Tonkinensis Radix et Rhizoma[J]. China Journal of Chinese Materia Medica, 2017, 42(13): 2439-2442.] DOI: 10.19540/j.cnki.cjcmm.20170609.012.

5.周思雨, 陈金鹏, 刘志东, 等. 山豆根的化学成分和药理作用的研究进展[J]. 中草药, 2021, 52(5): 1510-1521. [Zhou SY, Chen JP, Liu ZD, et al. Research progress on chemical constituents and pharmacological effects of Sophorae Tonkinensis Radix et Rhizoma[J]. Chinese Traditional and Herbal Drugs, 2021, 52(5): 1510-1521.] DOI: 10.7501/j.issn.0253-2670.2021.05.033.

6.闫晓云, 秦凌峰, 张瑞, 等. 山豆根化学成分及降糖活性研究[J]. 药学学报, 2024, 59(11): 3135-3140. [Yan XY, Qin LF, Zhang R, et al. Chemical consitituents and hypoglycemic activity of Sophora tonkinensis[J]. Acta Pharmaceutica Sinica, 2024, 59(11): 3135-3140.] DOI: 10.16438/j.0513-4870.2024-0549.

7.才子航, 张香玉, 张小龙, 等. 山豆根毒性及其配伍减毒作用的研究进展[J]. 上海中医药大学学报, 2025, 39(1): 90-98. [Cai  ZH, Zhang XY, Zhang XL, et al. Research progress on toxicity of Radix Sophorae Tonkinensis Radixed Rhizoma and effect of its compatibility to reduce toxin[J]. Academic Journal of Shanghai University of Traditional Chinese Medicine, 2025, 39(1): 90-98.] DOI: 10.16306/j.1008-861x.2025.01.012.

8.戎萍, 张喜莲, 刘晖, 等. 基于《中华人民共和国药典》探讨含毒性中药饮片的中成药现状与思考[J]. 辽宁中医杂志, 2023, 50(6): 178-182. [Rong P, Zhang XL, Liu H, et al. Current situation, problems and solutions of Chinese patent medicines containing toxic Chinese traditional medicine decoction pieces based on Pharmacopoeia of The People's Republic of China[J]. Liaoning Journal of Traditional Chinese Medicine, 2023, 50(6):178-182.] DOI: 10.13192/j.issn.1000-1719.2023.06.050.

9.杨雪, 张冰, 夏东胜, 等. 毒性药材山豆根的中医药古籍挖掘研究[J]. 中华中医药杂志, 2017, 32(12): 5527-5530. [Yang X, Zhang B, Xia DS, et al. Study on the Chinese medicine ancient books excavation of Radix Sophorae subprostratae[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2017, 32(12): 5527-5530.] https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201712079.htm.

10.余登香, 王淑娜, 傅月朦, 等. 山豆根中生物碱类成分的毒性及机制研究进展[J]. 中国实验方剂学杂志, 2022, 28(6): 262-271. [Yu DX, Wang SN, Fu YM, et al. Toxicity and mechanism of alkaloids in sophorae Tonkinensis Radix et Rhizoma: a review[J]. Chinese Journal of Experimental Traditional Medical Formulae, 2022, 28(6): 262-271.] DOI: 10.13422/j.cnki.syfjx.20220523.

11.刘巨钊, 马苗苗, 田晓黎, 等. 基于文献计量学的重楼研究现状及热点分析[J]. 药物评价研究, 2022, 45(11): 2347-2356. [Liu JZ, Ma MM, Tian XL, et al. Research status and hotspot analysis of Paris polyphylla based on bibliometrics[J]. Drug Evaluation Research, 2022, 45(11): 2347-2356.] DOI: 10.7501/j.issn.1674-6376.2022.11.024.

12.汪竹芸, 阳勇, 张小梅, 等. 青蒿研究进展的CiteSpace知识图谱建立[J]. 中成药, 2022, 44(1): 300-305. [Wang ZY, Yang  Y, Zhang XM, et al. Establishment of CiteSpace knowledge map of Artemisia annua research progress[J]. Chinese Traditional Patent Medicine, 2022, 44(1): 300-305.] DOI: 10.3969/j.issn.1001-1528.2022.01.058.

13.王永佳. 基于CiteSpace与VOSviewer的针刺治疗腰椎间盘突出症知识图谱分析[D]. 沈阳: 辽宁中医药大学, 2021. DOI: 10.27213/d.cnki.glnzc.2021.000541.

14.李双霜, 谭天颖, 曾兴琳, 等. 基于VOSviewer和CiteSpace对中医药治疗慢传输型便秘的可视化分析[J]. 湖南中医杂志, 2024, 40(4): 127-133. [Li SS, Tan TY, Zeng XL, et al. Visual analysis of traditional Chinese medicine in the treatment of slow transit constipation based on VOSviewer and CiteSpace[J]. Hunan Journal of Traditional Chinese Medicine, 2024, 40(4): 127-133.] DOI: 10.16808/j.cnki.issn1003-7705.2024.04.034.

15.张启佳, 徐瀚峰, 万莉, 等. 肺癌中药治疗研究文献计量学分析[J]. 中成药, 2023, 45(2): 665-670. [Zhang QJ, Xu HF, Wang L, et al. Bibliometric analysis of traditional Chinese medicine treatment of lung cancer[J]. Chinese Traditional Patent Medicine, 2023, 45(2): 665-670.] DOI: 10.3969/j.issn.1001-1528.2023.02.060.

16.Tu JX, Lin XT, Ye HQ, et al. Global research trends of artificial intelligence applied in esophageal carcinoma: a bibliometric analysis (2000-2022) via CiteSpace and VOSviewer[J]. Front Oncol, 2022, 12: 972357. DOI: 10.3389/fonc.2022.972357.

17.周超峰. 文献计量常用软件比较研究[D]. 武汉: 华中师范大学, 2017. https://cdmd.cnki.com.cn/Article/CDMD-10511-1017251648.htm.

18.Zeng L, Ma G, Chen K, et al. Bibliometric analysis of rheumatic immune related adverse events associated with immune checkpoint inhibitors[J]. Front Immunol, 2023, 14: 1242336. DOI: 10.3389/fimmu.2023.1242336.

19.刘薇芝, 李玲, 吴菁, 等. 中国居家药学服务的文献计量学研究及可视化分析[J]. 中国医院药学杂志, 2022, 42(24): 2670-2675. [Liu WZ, Li L, Wu J, et al. A bibliometric and visual analysis of home pharmaceutical care in China[J]. Chinese Journal of Hospital Pharmacy, 2022, 42(24): 2670-2675.] DOI: 10.13286/j.1001-5213.2022.24.17.

20.董国豪, 潜伟. 普赖斯与科学史定量研究[J]. 科学学研究, 2017, 35(5): 667-675, 680. [Dong GH, Qian W. Derek John de Solla Price and the quantitative study of the history of science[J]. Studies in Science of Science, 2017, 35(5): 667-675, 680.] DOI: 10.16192/j.cnki.1003-2053.2017.05.003.

21.张子婷, 郑彦宁, 袁芳. 多指标核心作者识别方法研究[J]. 现代情报, 2020, 40(7): 144-151. [Zhang ZT, Zheng YN, Yuan F. Research on multiple-indicators method on identifying the core authors[J]. Journal of Modern Information, 2020, 40(7): 144-151.] DOI: 10.3969/j.issn.1008-0821.2020.07.015.

22.车梦竹, 成泽东. 针灸治疗动脉粥样硬化的知识图谱可视化分析[J]. 辽宁中医杂志, 2023, 50(4): 160-164, 226. [Che  MZ, Cheng ZD. Visualization analysis of knowledge map of acupuncture treatment of atherosclerosis[J]. Liaoning Journal of Traditional Chinese Medicine, 2023, 50(4): 160-164, 226.] DOI: 10.13192/j.issn.1000-1719.2023.04.042.

23.冯涛, 宋佳敏, 孙立丽, 等. 基于CiteSpace知识网络图谱的黄芩研究进展[J]. 中国现代应用药学, 2022, 39(19): 2549-2556. [Feng T, Song JM, Sun LL, et al. Research progress of scutellaria baicalensis based on CiteSpace knowledge network map[J]. Chinese Journal of Modern Applied Pharmacy, 2022, 39(19): 2549-2556.] DOI: 10.13748/j.cnki.issn1007-7693.2022.19.018.

24.唐芳, 曲丽媛, 岑柏宏, 等. 基于CiteSpace对（制）何首乌的研究热点及发展趋势的可视化分析[J]. 中国临床药理学杂志, 2024, 40(9): 1363-1367. [Tang F, Qu LY, Cen BH, et al. Visual analysis of research hotspots and development trends of Polygoni Multiflori Radix (processed) based on CiteSpace[J]. The Chinese Journal of Clinical Pharmacology, 2024, 40(9): 1363-1367.] DOI: 10.13699/j.cnki.1001-6821.2024.09.026.

25.温乐乐, 叶梓, 江丽洁, 等. 基于CiteSpace的雷公藤红素知识图谱分析[J]. 中草药, 2024, 55(11): 3789-3804. [Wen LL, Ye Z, Jiang LJ, et al. Knowledge mapping analysis of celastrol based on CiteSpace[J]. Chinese Traditional and Herbal Drugs, 2024, 55(11): 3789-3804.] DOI: 10.7501/j.issn.0253-2670.2024.11.021.

26.康世奇, 杨京航, 苏晓慧, 等. 中药马钱子研究进展的CiteSpace知识图谱分析[J]. 中国中药杂志, 2021, 46(5): 1043-1052. [Kang SQ, Yang JH, Su XH, et al. Knowledge map analysis of research progress of Strychni Semen based on CiteSpace[J]. China Journal of Chinese Materia Medica, 2021, 46(05): 1043-1052.] DOI: 10.19540/j.cnki.cjcmm.20201223.401.

27.韦彩柳, 李金莎, 裴京楠, 等. 山豆根对中枢神经系统的毒性作用及机制研究进展[J]. 中医药导报, 2024, 30(12): 99-102. [Wei CL, Li JS, Pei JN, et al. Research progress on the toxic effects and mechanisms of Shandougen (Sophorae Tonkinensis Radix et Rhizoma) on the central nervous system[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2024, 30(12): 99-102.] DOI: 10.13862/j.cn43-1446/r.2024.12.018.

28.魏欣, 纪瑞锋, 徐娟, 等. 基于VOSviewer和CiteSpace知识图谱对绞股蓝研究热点与趋势分析[J]. 中草药, 2024, 55(9): 3064-3076. [Wei X, Ji RF, Xu J, et al. Analysis of research hotspots and trends in Gynostemma pentaphyllum based on VOSviewer and CiteSpace knowledge graph[J]. Chinese Traditional and Herbal Drugs, 2024, 55(9): 3064-3076.] DOI: 10.7501/j.issn.0253-2670.2024.09.020.

29.万元胜, 赵立波, 刘金玉, 等. 骨健康管理卫生经济学评价的趋势与热点：基于CiteSpace的可视化分析[J]. 中国医院药学杂志, 2023, 43(1): 28-33. [Wan YS, Zhao LB, Liu JY, et al. Trends and hot spots in health economics evaluation of bone health management: a visualized analysis based on Citespace[J]. Chinese Journal of Hospital Pharmacy, 2023, 43(1): 28-33.] DOI: 10.13286/j.1001-5213.2023.01.05.

30.Ma X, Lin H, Zhang J, et al. Extraction and identification of matrine-type alkaloids from Sophora moorcroftiana using double-templated molecularly imprinted polymers with HPLC-MS/MS[J]. J Sep Sci, 2018, 41(7): 1691-1703. DOI: 10.1002/jssc.201701133.

31.段媛媛. 山豆根化学成分分析及苦参碱致肝损伤作用机制研究[D]. 南宁: 广西师范大学, 2023. DOI: 10.27036/d.cnki.ggxsu.2023.000918.

32.张帅男, 李红美, 李煦照. 山豆根对小鼠大脑毒性作用的组学和生物信息学研究[J]. 沈阳药科大学学报, 2023, 40(3): 343-349. [Zhang SN, Li HM, Li XZ. Omics and bioinformatics studies of the brain toxicity of Sophorae Tonkinensis Radix et Rhizoma in mice[J]. Journal of Shenyang Pharmaceutical University, 2023, 40(3): 343-349.] DOI: 10.14066/j.cnki.cn21-1349/r.2021.0613.

33.刘甜甜, 张彦丽, 马丽娜, 等. 山豆根不合理使用致中枢神经毒性的研究进展[J]. 中国医院用药评价与分析, 2022, 22(9): 1149-1152. [Liu TT, Zhang YL, Ma LN, et al. Progress of neurotoxicity induced by irrational use of Sophorae Tonkinensis Radix et Rhizoma[J]. Evaluation and Analysis of Drug-use in Hospitals of China, 2022, 22(9): 1149-1152.] DOI: 10.14009/j.issn.1672-2124.2022.09.028.

34.王培珍, 周海芳, 马诗瑜, 等. 1 011张门急诊含山豆根饮片处方的点评与分析[J]. 中医药管理杂志, 2022, 30(5): 96-98. [Wang PZ, Zhou HF, Ma SY, et al. Comments and analysis of 1011 prescriptions containing Radix Sophorae Tonkinensis in outpatient and emergency department[J]. Journal of Traditional Chinese Medicine Management, 2022, 30(5): 96-98.] https://d.wanfangdata.com.cn/periodical/zyyglzz202205041.

35.徐雪, 吴国清. 我院门急诊山豆根饮片处方的专项点评与分析[J]. 中国乡村医药, 2022, 29(5): 50-51. [Xu X, Wu GQ. Special comments and analysis on the prescription of Sophora Tonkinensis decoction pieces in outpatient and emergency department of our hospital[J]. Chinese Journal of Rural Medicine and Pharmacy, 2022, 29(5): 50-51] DOI: 10.3969/j.issn.1006-5180.2022.05.029.

36.张胜利, 王超众, 闫广利, 等. 山豆根抗肿瘤活性成分及其作用机制研究进展[J]. 中草药, 2023, 54(20): 6844-6855. [Zhang  SL, Wang CZ, Yan GL, et al. Research progress on antitumor bioactive compounds and mechanisms of Sophorae Tonkinensis Radix et Rhizoma[J]. Chinese Traditional and Herbal Drugs, 2023, 54(20): 6844-6855.] DOI: 10.7501/j.issn.0253-2670.2023.20.028.

37.朱源玉, 杨坤鹏, 林华杰, 等. 基于网络药理学和分子对接技术探讨山豆根抗鼻咽癌作用机制研究[J]. 吉林医学, 2025, 46(5): 1034-1039. [Zhu YY, Yang KP, Lin HJ, et al. Study on the mechanism of sophora flavescens against nasopharyngeal carcinoma based on network pharmacology and molecular docking techniques[J]. Jilin Medical Journal, 2025, 46(5): 1034-1039.] DOI: 10.3969/j.issn.1004-0412.2025.05.005.

38.王淑娜, 杨丽雅, 余登香, 等. 山豆根多糖的制备、单糖组成及体外抗肿瘤作用[J]. 中国新药杂志, 2023, 32(11): 1155-1162. [Wang SN, Yang LY, Yu DX, et al. Preparation,monosaccharide composition and in vitro antitumor effect of polysaccharide from Sophora Tonkinensis Radix et Rhizoma[J]. Chinese Journal of New Drugs, 2023, 32(11): 1155-1162] DOI: 10.3969/j.issn.1003-3734.2023.11.012.

39.李曦, 高健美, 龚其海. 山豆根药理作用及毒性研究进展[J]. 世界中医药, 2022, 17(5): 743-747, 752. [Li X, Gao JM, Gong QH. Advances in pharmacological effects and toxicity of Subprostrate Sophorais[J]. World Chinese Medicine, 2022, 17(5): 743-747, 752.] DOI: 10.3969/j.issn.1673-7202.2022.05.025.

40.Pan QM, Zhang GJ, Huang RZ, et al. Cytisine-type alkaloids and flavonoids from the rhizomes of Sophora Tonkinensis[J]. J Asian Nat Prod Res, 2016, 18(5): 429-435. DOI: 10.1080/10286020. 2015.1131680.

41.王莉萍, 张泽安. 山豆根的毒性病理学研究进展[J]. 上海中医药大学学报, 2015, 29(6): 80-82. [Wang LP, Zhang ZA. Research progress on toxicologic pathology of Radix et Rhizoma Sophorae Tonkinensise[J]. Academic Journal of Shanghai University of Traditional Chinese Medicine, 2015, 29(6): 80-82.] DOI: 10.16306/j.1008-861x.2015.06.021.

42.Gu Y, Lu J, Sun W, et al. Oxymatrine and its metabolite matrine contribute to the hepatotoxicity induced by Radix Sophorae Tonkinensis in mice[J]. Exp Ther Med, 2019, 17(4): 2519-2528. DOI: 10.3892/etm.2019.7237.

43.孙文学, 宁炼, 唐黎明. 山豆根保肝作用与肝毒性研究进展 [J]. 中华中医药学刊, 2021, 39(10): 50-54. [Sun WX, Ning L, Tang M. Research on hepatoprotective effect and hepatotoxicity of Shandougen (Sophorae Tonkinensis Radix et Rhizoma)[J]. Chinese Archives of Traditional Chinese Medicine, 2021, 39(10): 50-54.] DOI: 10.13193/j.issn.1673-7717.2021.10.010.

44.华应顺. 山豆根与其常见7种伪品的鉴别[J]. 西部中医药, 2015, 28(4): 21-24. [Hua YS. Identification of Shandougen and its seven common conterfeits[J]. Western Journal of Traditional Chinese Medicine, 2015, 28(4): 21-24.] DOI: 10.3969/j.issn.1004-6852.2015.04.007.

45.张婷婷. 山豆根及北豆根的网络药理学、分子对接与抗癌抗菌的研究[D]. 天津: 天津科技大学, 2023. DOI: 10.27360/d.cnki.gtlgy.2023.001200.

46.陈影. 山豆根配伍减毒及毒性作用部位研究[D]. 北京: 中国中医科学院, 2018. https://cdmd.cnki.com.cn/Article/CDMD-84502-1018257167.htm.

47.胡昕, 鄢良春, 宋军. 山豆根神经毒性的配伍减毒作用和机制研究[J]. 四川中医, 2018, 36(7): 68-71. [Hu X, Yan LC, Song J. Study on the toxicity and mechanism of reducing the compatibility of Radix Sophorae Tonkinensis neurotoxicity[J]. Journal of Sichuan of Traditional Chinese Medicine, 2018, 36(7): 68-71.] https://www.cnki.com.cn/Article/CJFDTotal-SCZY201807029.htm.

48.周沁阳, 马克坚, 宋娜丽, 等. 山豆根毒性认知及炮制减毒思考[J]. 云南中医中药杂志. 2019: 93-94. [Zhou QY, Ma  KJ, Song LN, et al. Toxicity cognition and processing attenuation thinking of Sophora Tonkinensis Gagnep[J]. Yunnan Journal of Traditional Chinese Medicine, 2019, 40(5): 93-94.] DOI: 10.16254/j.cnki.53-1120/r.2019.05.036.