Objective  To establish a quantitative method for evaluating the quality of Salvia miltiorrhiza decoction pieces and determine the content limit range of salvianolic acid B.

Methods  Referring to the detection method of raw Salvia miltiorrhiza in the Chinese Pharmacopoeia (2025 Edition), Volume I, the content of salvianolic acid B in 344 batches of Salvia miltiorrhiza decoction pieces produced by different enterprises was determined. Robust Z-score method was used for statistical analysis of the sample data, and the Z-score was calculated based on the median and standardized interquartile range to identify the distribution characteristics of the data.

Results  Calculated on a dry basis, it is suggested that the content limit of salvianolic acid B in Salvia miltiorrhiza decoction pieces be 2.5% to 5.5% (g/g), which covers the robust distribution range of more than 95% of the samples.

Conclusion  This study, combining the pharmacopoeia method with robust statistical techniques, proposes a scientifically reasonable content limit, which can effectively guide the quality control and evaluation of the superiority and inferiority of Salvia miltiorrhiza decoction pieces, providing practical references for the standardization of traditional Chinese medicine decoction pieces.

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