Sambucus adnata Wall. is a commonly used medicine among ethnic minorities in China, containing chemical components such as flavonoids, terpenes, phenolic acids, and sterols. It has traditional effects such as dispelling wind and inducing diuresis, dispersing blood stasis, and activating blood circulation. Modern research shows that this herb has various pharmacological activities such as anti-inflammatory, antioxidant, analgesic, bone protection, and immune protection. At present, the number of drugs developed based on Sambucus adnata Wall. and its active ingredients is still relatively small, and its medicinal potential needs further exploration. This article systematically reviews the current status of the quality standards for Sambucus adnata Wall., and based on the concept of quality markers (Q-Marker), analyzes and predicts the potential Q-Markers of Sambucus adnata Wall. from multiple perspectives, including traditional efficacy and medicinal properties, plant relationships, ingredient and pharmacological associations, chemical component predictability, origin differences, extraction and purification, compound compatibility, and network pharmacology. The aim is to provide theoretical basis for improving its quality standards and promoting the development of medicinal resources.

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