Objective To investigate the preparation process of Jianpi Tiaotang pills.

Methods The extraction process was optimized using the CRITIC method combined with the Box-Behnken response surface method. The influencing factors were water addition, decoction time, and decoction frequency, while the evaluation criteria were dry extract yield and berberine hydrochloride transfer rate. For the pill-forming process, the effects of fine powder ratio, extract concentration density, drying temperature, and drying time were investigated, with formability, moisture content, disintegration time, and cracking rate as evaluation indexes. The molding process was optimized and determined via single-factor experiments.

Results The preferred preparation process of Jianpi Tiaotang pills was as follows: Paeonia suffruticosa, stir-fried Coicis Semen, and stir-fried Hordeum Vulgare were mixed, pulverized, and passed through a 100-mesh sieve. For the remaining medicinal materials, perform water decoctions 3 times, each for 1 hour. Add 11 times the amount of water for the first decoction, 10 times for the second, and 9 times for the third. The extracted liquids were combined, filtered, and concentrated under reduced pressure to a relative density of 1.20-1.25 (80 ℃). The mass was formed into pills and dried in an oven at 70 ℃ for 12 h to obtain the final product.

Conclusion This preparation method is stable and reliable, providing a scientific basis for the industrial production and quality control of Jianpi Tiaotang pills.

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